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Autor:
Lucia Morgado-Palacin
Publikováno v:
The Journal of cell biology. 220(9)
Gaia Pigino studies the molecular mechanisms and principles of self-organization in cilia using 3D cryo-EM.
Autor:
Liying Wang, Chao Liu, Bo Yang, Haotian Zhang, Jian Jiao, Ruidan Zhang, Shujun Liu, Sai Xiao, Yinghong Chen, Bo Liu, Yanjie Ma, Xuefeng Duan, Yueshuai Guo, Mengmeng Guo, Bingbing Wu, Xiangdong Wang, Xingxu Huang, Haitao Yang, Yaoting Gui, Min Fang, Luo Zhang, Shuguang Duo, Xuejiang Guo, Wei Li
Publikováno v:
The Journal of cell biology. 221(7)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causal pathogen of the ongoing global pandemic of coronavirus disease 2019 (COVID-19). Loss of smell and taste are symptoms of COVID-19, and may be related to cilia dysfunction. Here
Autor:
Shalini Rawat, Dhruba Chatterjee, Rituraj Marwaha, Gitanjali Charak, Gaurav Kumar, Shrestha Shaw, Divya Khatter, Sheetal Sharma, Cecilia de Heus, Nalan Liv, Judith Klumperman, Amit Tuli, Mahak Sharma
Publikováno v:
The Journal of cell biology. 222(1)
Arl8b, an Arf-like GTP-binding protein, regulates cargo trafficking and positioning of lysosomes. However, it is unknown whether Arl8b regulates lysosomal cargo sorting. Here, we report that Arl8b binds to the Rab4 and Rab14 interaction partner, RUN
Autor:
Caroline Cvetkovic, Rajan Patel, Arya Shetty, Matthew K. Hogan, Morgan Anderson, Nupur Basu, Samira Aghlara-Fotovat, Srivathsan Ramesh, Debosmita Sardar, Omid Veiseh, Michael E. Ward, Benjamin Deneen, Philip J. Horner, Robert Krencik
Publikováno v:
The Journal of cell biology. 221(4)
Astrocyte reactivity can directly modulate nervous system function and immune responses during disease and injury. However, the consequence of human astrocyte reactivity in response to specific contexts and within neural networks is obscure. Here, we
Publikováno v:
The Journal of cell biology. 220(11)
The subcellular localization of RAS GTPases defines the operational compartment of the EGFR-ERK1/2 signaling pathway within cells. Hence, we used live-cell imaging to demonstrate that endogenous KRAS and NRAS tagged with mNeonGreen are predominantly
Autor:
Cowell, Alana R, Jacquemet, Guillaume, Singh, Abhimanyu K, Varela, Lorena, Nylund, Anna S, Ammon, York-Christoph, Brown, David G, Akhmanova, Anna, Ivaska, Johanna, Goult, Benjamin T, Sub Cell Biology, Celbiologie
Publikováno v:
The Journal of Cell Biology
Journal of Cell Biology, 220(9). Rockefeller University Press
Journal of Cell Biology, 220(9). Rockefeller University Press
Cowell et al. show that talin rod domain–containing protein 1 (TLNRD1), a protein with homology to the central region of the integrin regulator, talin, has retained the diverse interactions of talin R7R8 but has developed distinct functionality as
Autor:
Laura M. Machesky, Michael F. Olson
Publikováno v:
The Journal of Cell Biology
Olson and Machesky discuss work from the Way laboratory that reveals how ARP3B isoform-specific ARP2/3 complexes lead to faster disassembly of branched actin filaments.
The ARP2/3 complex promotes branched actin networks, but the importance of s
The ARP2/3 complex promotes branched actin networks, but the importance of s
Publikováno v:
The Journal of cell biology. 220(10)
Glycosylation is a diverse and abundant modification of proteins, lipids and RNA. The fidelity of glycosylation is, in part, assured by the correct compartmentalisation of Golgi-resident glycosylation enzymes within the Golgi stack. The COPI adaptor
Autor:
Areej Abu Rmaileh, Balakrishnan Solaimuthu, Anees Khatib, Shirel Lavi, Mayur Tanna, Arata Hayashi, Michal Ben Yosef, Michal Lichtenstein, Nir Pillar, Yoav D. Shaul
Publikováno v:
The Journal of cell biology. 221(7)
The intricate neuronal wiring during development requires cytoskeletal reorganization orchestrated by signaling cues. Because cytoskeletal remodeling is a hallmark of cell migration, we investigated whether metastatic cancer cells exploit axon guidan
Autor:
Yihang Li, Maria F. Pazyra-Murphy, Daina Avizonis, Mariana de Sá Tavares Russo, Sophia Tang, Chiung-Ya Chen, Yi-Ping Hsueh, Johann S. Bergholz, Tao Jiang, Jean J. Zhao, Jian Zhu, Kwang Woo Ko, Jeffrey Milbrandt, Aaron DiAntonio, Rosalind A. Segal
Publikováno v:
The Journal of cell biology. 221(2)
Cancer patients frequently develop chemotherapy-induced peripheral neuropathy (CIPN), a painful and long-lasting disorder with profound somatosensory deficits. There are no effective therapies to prevent or treat this disorder. Pathologically, CIPN i