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Autor:
Laura M. Machesky, Michael F. Olson
Publikováno v:
The Journal of Cell Biology
Olson and Machesky discuss work from the Way laboratory that reveals how ARP3B isoform-specific ARP2/3 complexes lead to faster disassembly of branched actin filaments.
The ARP2/3 complex promotes branched actin networks, but the importance of s
The ARP2/3 complex promotes branched actin networks, but the importance of s
Publikováno v:
The Journal of cell biology. 220(10)
Glycosylation is a diverse and abundant modification of proteins, lipids and RNA. The fidelity of glycosylation is, in part, assured by the correct compartmentalisation of Golgi-resident glycosylation enzymes within the Golgi stack. The COPI adaptor
Autor:
Chad Liu, Nalin Ratnayeke, Jeannine Gerhardt, Marielle S. Köberlin, Madhura Deshpande, Tobias Meyer, Yilin Fan
Publikováno v:
The Journal of Cell Biology
Fan et al. show that replisome disassembly during S phase is required for efficient DNA replication by recycling essential replisome components between chromatin-bound and soluble compartments.
After two converging DNA replication forks meet, ac
After two converging DNA replication forks meet, ac
Autor:
Michael J Newbold, Anurag Paul, Jun-Lin Guan, Megan E Bischoff, Jarek Meller, Nicholas J Talbot, Adam D Price, Yuanwei Zang, Maria F. Czyzyk-Krzeska, Birgit Ehmer, Johnson Chu, David R. Plas
Publikováno v:
The Journal of Cell Biology
The work identifies a noncanonical autophagic program mediated by the hominid-specific LC3C paralog functioning downstream from the von Hippel–Lindau tumor suppressor. The program targets for lysosomal degradation postdivision midbodies in a mechan
Autor:
Gohta Goshima, Kenta Tsuchiya
Publikováno v:
The Journal of cell biology. 220(12)
γ-Tubulin complex acts as the predominant microtubule (MT) nucleator that initiates MT formation and is therefore an essential factor for cell proliferation. Nonetheless, cellular MTs are formed after experimental depletion of the γ-tubulin complex
Autor:
Johanna Ivaska, Hellyeh Hamidi
Publikováno v:
The Journal of Cell Biology
Hamidi and Ivaska preview work from the Korolchuk laboratory describing focal adhesions as hubs mediating growth factor signaling via mTORC1 and amino acid input into the cell.
Cell adhesion controls cell survival and proliferation via multiple
Cell adhesion controls cell survival and proliferation via multiple
Publikováno v:
The Journal of cell biology. 221(1)
Mitochondria and peroxisomes are independent but functionally closely related organelles. A few proteins have been characterized as dual-organelle locating proteins with distinct or similar roles on mitochondria and peroxisomes. MARCH5 is a mitochond
Autor:
Jodi Nunnari, Chad Lerner, Shona A. Mookerjee, Eddy Gibbs, Katherine Labbé, Maxence Le Vasseur
Publikováno v:
The Journal of cell biology. 220(11)
Mitochondrial function is integrated with cellular status through the regulation of opposing mitochondrial fusion and division events. Here we uncover a link between mitochondrial dynamics and lipid metabolism by examining the cellular role of mitoch
Publikováno v:
The Journal of Cell Biology
This study presents a new accretion model for spontaneous microtubule formation. In this model, microtubules form through a multitude of pathways and sheet-like oligomeric intermediates in a process akin to crystal growth.
Microtubules are dynam
Microtubules are dynam
Autor:
Jean Gautier, Benjamin R. Schrank
Publikováno v:
The Journal of Cell Biology
Schrank and Gautier discuss the generation and function of nuclear domains during DNA repair with a special focus on nuclear actin polymerization.
Eukaryotic nuclei are organized into nuclear domains that unite loci sharing a common function. Th
Eukaryotic nuclei are organized into nuclear domains that unite loci sharing a common function. Th