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Autor:
Valeria Iansante, Dick Heinegård, Mattia Capulli, Daria Capece, Emma Åhrman, Andrea Del Fattore, Anna Teti, Edoardo Alesse, Nadia Rucci, Anna Rufo, Marina Alamanou, Francesca Zazzeroni
Publikováno v:
The Journal of Cell Biology
The PRELP heparin sulfate–binding protein translocates to the nucleus, where it impairs NF-κB transcriptional activity, which in turn regulates bone homeostasis.
Proline/arginine-rich end leucine-rich repeat protein (PRELP) is a glycosaminogl
Proline/arginine-rich end leucine-rich repeat protein (PRELP) is a glycosaminogl
Autor:
Leonie van Zeijl, Friso R. Postma, Aafke Ariaens, Nullin Divecha, Bas Ponsioen, Wouter H. Moolenaar, Kees Jalink, Ben N G Giepmans, Péter Várnai, Tamas Balla
Publikováno v:
Journal of Cell Biology, 177(5), 881-891. ROCKEFELLER UNIV PRESS
The Journal of Cell Biology
The Journal of Cell Biology
Cell-cell communication through connexin43 (Cx43)-based gap junction channels is rapidly inhibited upon activation of various G protein coupled receptors; however, the mechanism is unknown. We show that Cx43-based cell-cell communication is inhibited
Publikováno v:
The Journal of Cell Biology
The second messenger cyclic adenosine monophosphate (cAMP) plays a pivotal role in axonal growth and guidance, but its downstream mechanisms remain elusive. In this study, we report that type II protein kinase A (PKA) is highly enriched in growth con
Autor:
Alain Beley, Stéphane Savary, Françoise Cadepond, Sabrina Leclercq, Stéphane Fourcade, Maurice Bugaut, Pascal G.P. Martin, Maria Rita Lecca, Thierry Pineau, Nathalie Bertrand, Catherine Gondcaille, Dirk De Craemer, Marianne Depreter, Sandrine Duclos, Frank Roels, Martine El-Etr
Publikováno v:
The Journal of Cell Biology
JOURNAL OF CELL BIOLOGY
Journal of Cell Biology
Journal of Cell Biology, Rockefeller University Press, 2005, 169 (1), pp.93-104. ⟨10.1083/jcb.200501036⟩
JOURNAL OF CELL BIOLOGY
Journal of Cell Biology
Journal of Cell Biology, Rockefeller University Press, 2005, 169 (1), pp.93-104. ⟨10.1083/jcb.200501036⟩
X-linked adrenoleukodystrophy (X-ALD) is a demyelinating disease due to mutations in the ABCD1 (ALD) gene, encoding a peroxisomal ATP-binding cassette transporter (ALDP). Overexpression of adrenoleukodystrophy-related protein, an ALDP homologue encod
Autor:
Yun Li, Patricia Camacho
Publikováno v:
The Journal of Cell Biology
We demonstrated previously that calreticulin (CRT) interacts with the lumenal COOH-terminal sequence of sarco endoplasmic reticulum (ER) calcium ATPase (SERCA) 2b to inhibit Ca2+ oscillations. Work from other laboratories demonstrated that CRT also i
Autor:
Wangsheng Yu, Deborah Sier, Lee Jamieson, Zoran Gatalica, E. Aubrey Thompson, Panos Z. Anastasiadis, Nicole R. Murray, Yesim Gökmen-Polar, Jie Zhang, Alan P. Fields
Publikováno v:
The Journal of Cell Biology
Protein kinase C iota (PKCiota) has been implicated in Ras signaling, however, a role for PKCiota in oncogenic Ras-mediated transformation has not been established. Here, we show that PKCiota is a critical downstream effector of oncogenic Ras in the
Autor:
Emma-Jane Williams, Fiona V. Howell, Isabel Matias, Vincenzo Di Marzo, Praveen Paul, Alberto Minassi, Gareth Williams, Carl Hobbs, Maria Grazia Cascio, Patrick Doherty, Tiziana Bisogno, Aniello Schiano-Moriello, Alessia Ligresti, Uma Gangadharan
Publikováno v:
The Journal of Cell Biology
Diacylglycerol (DAG) lipase activity is required for axonal growth during development and for retrograde synaptic signaling at mature synapses. This enzyme synthesizes the endocannabinoid 2-arachidonoyl-glycerol (2-AG), and the CB1 cannabinoid recept
Autor:
Anna Maria Curatola, Laurent Gagnoux-Palacios, Michael Dans, Paul A. Kedeshian, Filippo G. Giancotti, Agnese Mariotti
Publikováno v:
The Journal of Cell Biology
We have examined the mechanism and functional significance of hemidesmosome disassembly during normal epithelial cell migration and squamous carcinoma invasion. Our findings indicate that a fraction of EGF receptor (EGF-R) combines with the hemidesmo
Publikováno v:
The Journal of Cell Biology
Fibronectin's RGD-mediated binding to the α5β1 integrin is dramatically enhanced by a synergy site within fibronectin III domain 9 (FN9). Guided by the crystal structure of the cell-binding domain, we selected amino acids in FN9 that project in the
Publikováno v:
The Journal of Cell Biology
We have investigated the role of the small GTP-binding protein Rho in cytokinesis by microinjecting an inhibitor, C3 ribosyltransferase, into cultured cells. Microinjection of C3 into prometaphase or metaphase normal rat kidney epithelial cells induc