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Autor:
Panagiotis Mistriotis, Petr Kalab, Kaustav Bera, Yuqi Zhang, Konstantinos Konstantopoulos, Runchen Zhao, Sean X. Sun, Nicolas A. Perez-Gonzalez, Emily Wisniewski, Jeremy Keys, Jan Lammerding, Soontorn Tuntithavornwat, Yizeng Li, Eda Erdogmus, Robert A. Law
Publikováno v:
The Journal of Cell Biology
The nucleus is a significant obstacle that impedes migration of cells through confining microenvironments. Mistriotis et al. propose a conceptual model in which confinement-induced RhoA/myosin-II activation promotes nuclear volume expansion, nuclear
Autor:
Zhihao Sun, Jeffrey L. Brodsky
Publikováno v:
The Journal of Cell Biology
One third of the eukaryotic proteome matures in the secretory pathway. Sun and Brodsky describe the machinery that maintains protein fidelity and how its actions are coordinated.
Protein folding is inherently error prone, especially in the endop
Protein folding is inherently error prone, especially in the endop
Autor:
Xiaoming Liu, Thomas Abraham, Nicholas J. Buchkovich, Yoshinori Takahashi, Hong Gang Wang, Megan M. Young, Zhenyuan Tang, Han Chen, Xinwen Liang, Tatsuya Hattori, Haiyan He, Yuka Imamura-Kawasawa
Publikováno v:
The Journal of Cell Biology
Takahashi et al. perform a genome-wide CRISPR screen using the HaloTag-LC3 assay to gain insight into the mechanisms of phagophore closure. They identify a role for VPS37A in coordinating the ESCRT assembly on the phagophore for membrane closure.
Autor:
Daniel J. Marston, Philippe Roudot, Mitsu Ikura, Timothy A. Daugird, Christopher B. Marshall, Robert Rottapel, Jungsik Noh, María José Sandí, Sidney L. Lisanza, Klaus M. Hahn, John Sondek, Gaudenz Danuser, Mihai L. Azoitei
Publikováno v:
The Journal of Cell Biology
Azoitei, Noh, et al. engineer fluorescent biosensors to measure activation at the subcellular level and with subsecond kinetics of GEF-H1, a Rho GTPase that regulates cytoskeletal dynamics. In combination with computational image time series analysis
Autor:
Milena Pellikka, Norbert Perrimon, Frederik Wirtz-Peitz, Ulrich Tepass, Takashi Nishimura, Dong Yan, Jordan T. Silver, Yan Li, Tony J. C. Harris, Sérgio Simões, Richard Binari
Publikováno v:
The Journal of Cell Biology
Silver et al. show that the RhoGEF Cysts links apical polarity proteins to Rho1 and myosin activation at adherens junctions to support junctional and epithelial integrity in the Drosophila ectoderm.
The spatio-temporal regulation of small Rho GT
The spatio-temporal regulation of small Rho GT
Autor:
Marie-Hélène Verlhac
Publikováno v:
The Journal of Cell Biology
Journal of Cell Biology
Journal of Cell Biology, Rockefeller University Press, 2021, 220 (10), ⟨10.1083/jcb.202108030⟩
Journal of Cell Biology, 2021, 220 (10), ⟨10.1083/jcb.202108030⟩
Journal of Cell Biology
Journal of Cell Biology, Rockefeller University Press, 2021, 220 (10), ⟨10.1083/jcb.202108030⟩
Journal of Cell Biology, 2021, 220 (10), ⟨10.1083/jcb.202108030⟩
Mori et al. report that zygotes have active mechanisms that regulate the localization of paternal chromosomes during fertilization. These mechanisms guarantee that paternal chromosomes are kept in the zygote, and their disruption causes the eliminati
Autor:
Cowell, Alana R, Jacquemet, Guillaume, Singh, Abhimanyu K, Varela, Lorena, Nylund, Anna S, Ammon, York-Christoph, Brown, David G, Akhmanova, Anna, Ivaska, Johanna, Goult, Benjamin T, Sub Cell Biology, Celbiologie
Publikováno v:
The Journal of Cell Biology
Journal of Cell Biology, 220(9). Rockefeller University Press
Journal of Cell Biology, 220(9). Rockefeller University Press
Cowell et al. show that talin rod domain–containing protein 1 (TLNRD1), a protein with homology to the central region of the integrin regulator, talin, has retained the diverse interactions of talin R7R8 but has developed distinct functionality as
Autor:
Laura M. Machesky, Michael F. Olson
Publikováno v:
The Journal of Cell Biology
Olson and Machesky discuss work from the Way laboratory that reveals how ARP3B isoform-specific ARP2/3 complexes lead to faster disassembly of branched actin filaments.
The ARP2/3 complex promotes branched actin networks, but the importance of s
The ARP2/3 complex promotes branched actin networks, but the importance of s
Autor:
Katherine E. Bohnsack, Ákos Farkas
Publikováno v:
The Journal of Cell Biology
Farkas and Bohnsack describe advances in understanding targeting of tail-anchored (TA) proteins, including their insertion into the ER, how nascent TA proteins are selectively captured at the ribosome, and recently discovered quality control pathways
Autor:
Chad Liu, Nalin Ratnayeke, Jeannine Gerhardt, Marielle S. Köberlin, Madhura Deshpande, Tobias Meyer, Yilin Fan
Publikováno v:
The Journal of Cell Biology
Fan et al. show that replisome disassembly during S phase is required for efficient DNA replication by recycling essential replisome components between chromatin-bound and soluble compartments.
After two converging DNA replication forks meet, ac
After two converging DNA replication forks meet, ac