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Autor:
Panagiotis Mistriotis, Petr Kalab, Kaustav Bera, Yuqi Zhang, Konstantinos Konstantopoulos, Runchen Zhao, Sean X. Sun, Nicolas A. Perez-Gonzalez, Emily Wisniewski, Jeremy Keys, Jan Lammerding, Soontorn Tuntithavornwat, Yizeng Li, Eda Erdogmus, Robert A. Law
Publikováno v:
The Journal of Cell Biology
The nucleus is a significant obstacle that impedes migration of cells through confining microenvironments. Mistriotis et al. propose a conceptual model in which confinement-induced RhoA/myosin-II activation promotes nuclear volume expansion, nuclear
Autor:
Xiaoming Liu, Thomas Abraham, Nicholas J. Buchkovich, Yoshinori Takahashi, Hong Gang Wang, Megan M. Young, Zhenyuan Tang, Han Chen, Xinwen Liang, Tatsuya Hattori, Haiyan He, Yuka Imamura-Kawasawa
Publikováno v:
The Journal of Cell Biology
Takahashi et al. perform a genome-wide CRISPR screen using the HaloTag-LC3 assay to gain insight into the mechanisms of phagophore closure. They identify a role for VPS37A in coordinating the ESCRT assembly on the phagophore for membrane closure.
Autor:
Cowell, Alana R, Jacquemet, Guillaume, Singh, Abhimanyu K, Varela, Lorena, Nylund, Anna S, Ammon, York-Christoph, Brown, David G, Akhmanova, Anna, Ivaska, Johanna, Goult, Benjamin T, Sub Cell Biology, Celbiologie
Publikováno v:
The Journal of Cell Biology
Journal of Cell Biology, 220(9). Rockefeller University Press
Journal of Cell Biology, 220(9). Rockefeller University Press
Cowell et al. show that talin rod domain–containing protein 1 (TLNRD1), a protein with homology to the central region of the integrin regulator, talin, has retained the diverse interactions of talin R7R8 but has developed distinct functionality as
Autor:
Chad Liu, Nalin Ratnayeke, Jeannine Gerhardt, Marielle S. Köberlin, Madhura Deshpande, Tobias Meyer, Yilin Fan
Publikováno v:
The Journal of Cell Biology
Fan et al. show that replisome disassembly during S phase is required for efficient DNA replication by recycling essential replisome components between chromatin-bound and soluble compartments.
After two converging DNA replication forks meet, ac
After two converging DNA replication forks meet, ac
Autor:
Andrew Lombardo, Cécile Sauvanet, David J. McDermitt, Riasat Zaman, Raghuvir Viswanatha, Valerie Awad, Anthony Bretscher, Locke Ezra-Ros Bonomo
Publikováno v:
The Journal of Cell Biology
Zaman and Lombardo et al. characterize cells lacking all ERM proteins or their activating kinases. This reveals that active ERMs are local negative regulators of RhoA necessary to mediate the architecture of the apical domain.
Activated ezrin-ra
Activated ezrin-ra
Autor:
Daniel J. Marston, Philippe Roudot, Mitsu Ikura, Timothy A. Daugird, Christopher B. Marshall, Robert Rottapel, Jungsik Noh, María José Sandí, Sidney L. Lisanza, Klaus M. Hahn, John Sondek, Gaudenz Danuser, Mihai L. Azoitei
Publikováno v:
The Journal of Cell Biology
Azoitei, Noh, et al. engineer fluorescent biosensors to measure activation at the subcellular level and with subsecond kinetics of GEF-H1, a Rho GTPase that regulates cytoskeletal dynamics. In combination with computational image time series analysis
Autor:
Gaudenz Danuser, Ana F. David, Eric Betzig, Philippe Roudot, Daniel W. Gerlich, Wesley R. Legant
Publikováno v:
The Journal of Cell Biology
Vertebrate cells assemble mitotic spindles through multiple pathways. It is shown that Augmin-dependent, noncentrosomal nucleation generates the vast majority of microtubules in metaphase spindles. This results in a strong directional bias of microtu
Autor:
J. Ryan Feathers, W. Mike Henne, Evan Reetz, Natalie Ortiz Speer, Hanaa Hariri, Sean Rogers, Gang Fu, Rupali Ugrankar, Jade Bowerman, Daniela Nicastro, Sanchari Datta
Publikováno v:
The Journal of Cell Biology
Excess fatty acids are toxic to cells but can be sequestered as triacylglycerides in lipid droplets. Hariri et al. show that the tethering protein Mdm1 spatially regulates this process at the junction between the endoplasmic reticulum and the yeast v
Autor:
Nicholas D. Demers, Derrick Cheng, Rong Hua, Yuqing Wang, G. Angus McQuibban, Peter K. Kim, Amy Wong Strilchuk, Victoria Riccio, Miluska Vissa
Publikováno v:
The Journal of Cell Biology
Autophagy
Autophagy
The regulation of organelle abundance is crucial for cellular health and function. In this study, Riccio et al. show that the mitochondrial deubiquitinase USP30 localizes to peroxisomes, where it regulates PEX2-dependent pexophagy potential and demon
Autor:
Kazutoyo Ogino, Kazuhiro Nagata, Hiromi Hirata, Munechika Sugihara, Akira Kitamura, Yoshinobu Hirano, Shiori Ainuki, Daisuke Morito
Publikováno v:
The Journal of Cell Biology
Mutations in mysterin cause cerebrovascular moyamoya, but the mechanism of pathogenesis is unknown. Sugihara et al. report that mysterin stabilizes cytoplasmic lipid droplets through the activity of ATPase and ubiquitin ligase. Disease-associated mut