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pro vyhledávání: '"Yong J. Lee"'
Publikováno v:
The Journal of biological chemistry. 282(1)
Previous studies have shown that repeated application of TRAIL induces acquired resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Using human prostate adenocarcinoma DU-145 and human pancreatic carcinoma MiaPaCa-2 cells a
Publikováno v:
The Journal of biological chemistry. 280(49)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to be selective in the induction of apoptosis in cancer cells with minimal toxicity to normal tissues. However, not all cancers are sensitive to TRAIL-mediated apoptosis.
Autor:
Jae J, Song, Yong J, Lee
Publikováno v:
The Journal of biological chemistry. 280(29)
We have previously observed that glucose deprivation activates the ASK1-MEK-MAPK signal transduction pathway. In the present study, we reveal that two scaffolding proteins, JIP1 and JIP3, have a cross-talk that leads to the regulation of the ASK1-SEK
Autor:
Yong J. Lee, Jae J. Song
Publikováno v:
The Journal of biological chemistry. 278(47)
Overexpression of JNK binding domain inhibited glucose deprivation-induced JNK1 activation, relocalization of Daxx from the nucleus to the cytoplasm, and apoptosis signal-regulating kinase 1 (ASK1) oligomerization in human prostate adenocarcinoma DU-
Autor:
Jae J, Song, Juong G, Rhee, Mohan, Suntharalingam, Susan A, Walsh, Douglas R, Spitz, Yong J, Lee
Publikováno v:
The Journal of biological chemistry. 277(48)
Epitope-tagged glutaredoxin (GRX) was utilized to determine the role of GRX in oxidative stress-induced signaling and cytotoxicity in glucose-deprived human cancer cells (MCF-7/ADR and DU-145). GRX-overexpressing cells demonstrated resistance to gluc