Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Michael J. MacDonald"'
Publikováno v:
The Journal of biological chemistry. 290(17)
The lipid composition of insulin secretory granules (ISG) has never previously been thoroughly characterized. We characterized the phospholipid composition of ISG and mitochondria in pancreatic beta cells without and with glucose stimulation. The pho
Autor:
Noaman Hasan, Michael J. MacDonald, Scott W. Stoker, Melissa J. Longacre, Laura J. Brown, Mindy A. Kendrick
Publikováno v:
The Journal of biological chemistry. 284(51)
The cytosolic malic enzyme (ME1) has been suggested to augment insulin secretion via the malate-pyruvate and/or citrate-pyruvate shuttles, through the production of NADPH or other metabolites. We used selectable vectors expressing short hairpin RNA (
Publikováno v:
The Journal of biological chemistry. 282(42)
The mitochondria of pancreatic beta cells are believed to convert insulin secretagogues into products that are translocated to the cytosol where they participate in insulin secretion. We studied the hypothesis that short chain acyl-CoA (SC-CoAs) migh
Autor:
Robert A. Koza, Marc L. Reitman, Laura J. Brown, Carrie Everett, Michael J. MacDonald, Linda J. Marshall, Leonard A. Fahien, Leslie P. Kozak
Publikováno v:
The Journal of biological chemistry. 277(36)
The mitochondrial glycerol phosphate dehydrogenase (mGPD) is important for metabolism of glycerol phosphate for gluconeogenesis or energy production and has been implicated in thermogenesis induced by cold and thyroid hormone treatment. mGPD in combi
Publikováno v:
The Journal of biological chemistry. 277(36)
The activities of either the mitochondrial or cytosolic glycerol phosphate dehydrogenase (mGPD, cGPD) plus that of glycerol kinase are required for the use of glycerol in aerobic metabolism and gluconeogenesis. A knockout mouse lacking mGPD has reduc
Publikováno v:
The Journal of biological chemistry. 275(44)
Experiments do not support a recent claim that glutamate formed from the amination of citric acid cycle-derived alpha-ketoglutarate is a messenger in glucose-induced insulin secretion (Maechler, P., and Wollheim, C. (1999) Nature 402, 685-689). Gluco
Publikováno v:
The Journal of biological chemistry. 275(48)
Mitochondrial glycerol phosphate dehydrogenase (mGPD) is abundant in the normal pancreatic insulin cell, but its level is lowered 50% by diabetes. To evaluate mGPD expression, we cloned and characterized the 5′-flanking region of the human mGPD gen