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Autor:
Moritz Koch, Juergen Weitz, Raghu Kalluri, Sonia A. Melo, Lynda Chin, Jiabin Tang, Sahil Seth, Christoph Kahlert, Andrew Futreal, Alexei Protopopov, Jianhua Zhang
Publikováno v:
The Journal of biological chemistry. 289(7)
Exosomes are small vesicles (50–150 nm) of endocytic origin that are released by many different cell types. Exosomes in the tumor microenvironment may play a key role in facilitating cell-cell communication. Exosomes are reported to predominantly c
Publikováno v:
The Journal of biological chemistry. 288(18)
IMP3, a member of a family of insulin-like growth factor II (IGF-II) mRNA-binding proteins (IMPs), is expressed preferentially in triple-negative breast cancers, which are resistant to many chemotherapeutics. However, the mechanisms by which it impac
Autor:
Pål R. Njølstad, Helge Ræder, Bente B. Johansson, Rebecca Windmueller, Erling Tjora, Rohit N. Kulkarni, Ercument Dirice, Adrian Kee Keong Teo
Publikováno v:
The Journal of biological chemistry. 288(8)
Maturity onset diabetes of the young (MODY) is an autosomal dominant disease. Despite extensive research, the mechanism by which a mutant MODY gene results in monogenic diabetes is not yet clear due to the inaccessibility of patient samples. Induced