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Autor:
Payne Thomas Augustus, Nancy López-Antón, Hena Khalique, Siobhan Clerkin, Vaughan R. Leydon, Tim D Jones, Len Seymour, Alexander Raeside, Zainab Khalaf, Nathan Robertson, Shalom A. Gurjar, Richard P. Parker-Manuel, Ryan Cawood
Publikováno v:
The Journal of Biological Chemistry
Reliable, specific polyclonal and monoclonal antibodies are important tools in research and medicine. However, the discovery of antibodies against their targets in their native forms is difficult. Here, we present a novel method for discovery of anti
Publikováno v:
The Journal of Biological Chemistry
The severe acute respiratory syndrome (SARS) coronavirus (CoV) main protease represents an attractive target for the development of novel anti-SARS agents. The tertiary structure of the protease consists of two distinct folds. One is the N-terminal c
Autor:
Zhizhou Xia, Yun Tan, Ruibao Ren, Peihong Wang, Donghe Li, Zhangsen Huang, Ruihong Zhang, Ping Liu, Mingzhu Liu, Bo Jiao
Publikováno v:
The Journal of Biological Chemistry
RAS genes are the most commonly mutated in human cancers and play critical roles in tumor initiation, progression, and drug resistance. Identification of targets that block RAS signaling is pivotal to develop therapies for RAS-related cancer. As RAS
Autor:
Xiaoqin Yang, Qingqing Liu, Guangyu Long, Yabing Hu, Yves R. Boisclair, Zhenglong Gu, Qiaoming Long
Publikováno v:
The Journal of Biological Chemistry
Mitochondrial dysfunction is associated with a variety of human diseases including neurodegeneration, diabetes, nonalcohol fatty liver disease (NAFLD), and cancer, but its underlying causes are incompletely understood. Using the human hepatic cell li
Autor:
Yaqiong Lin, William C. Hwang, Boguslaw Stec, Eugenio Santelli, Michael Farzan, Wayne A. Marasco, Robert C. Liddington, Jianhua Sui, Lukasz Jaroszewski
Publikováno v:
The Journal of Biological Chemistry
Journal of Biological Chemistry
Journal of Biological Chemistry
Severe acute respiratory syndrome (SARS) is a newly emerged infectious disease that caused pandemic spread in 2003. The etiological agent of SARS is a novel coronavirus (SARS-CoV). The coronaviral surface spike protein S is a type I transmembrane gly
Autor:
Huang, I-Chueh, Bosch, Berend Jan, Li, Fang, Li, Wenhui, Lee, Kyoung Hoa, Ghiran, Sorina, Vasilieva, Natalya, Dermody, Terence S, Harrison, Stephen C, Dormitzer, Philip R, Farzan, Michael, Rottier, Peter J M, Choe, Hyeryun, LS Virologie
Publikováno v:
The Journal of Biological Chemistry
Journal of Biological Chemistry, 281(6), 3198. American Society for Biochemistry and Molecular Biology Inc.
Journal of Biological Chemistry, 281(6), 3198. American Society for Biochemistry and Molecular Biology Inc.
Viruses require specific cellular receptors to infect their target cells. Angiotensin-converting enzyme 2 (ACE2) is a cellular receptor for two divergent coronaviruses, SARS coronavirus (SARS-CoV) and human coronavirus NL63 (HCoV-NL63). In addition t
Autor:
Huili Li, Peter A. Greer, Lulu Zhang, Douglas L. Jones, Liwen Liang, Guo-Chang Fan, Lina Qu, Tianqing Peng, Ting Cao, Jianmin Li
Publikováno v:
The Journal of Biological Chemistry
The human cardiovascular system has adapted to function optimally in Earth's 1G gravity, and microgravity conditions cause myocardial abnormalities, including atrophy and dysfunction. However, the underlying mechanisms linking microgravity and cardia
Autor:
Philipp Markart, Peter A. Andreasen, Andreas Guenther, Klaus T. Preissner, Troels Wind, Rory E. Morty, Malgorzata Wygrecka, Sandip M. Kanse
Publikováno v:
The Journal of Biological Chemistry
Factor VII-activating protease (FSAP) is a novel plasma-derived serine protease structurally homologous to tissue-type and urokinase-type plasminogen activators. We demonstrate that plasminogen activator inhibitor-1 (PAI-1), the predominant inhibitor
Autor:
Gernot Riedel, Karima Schwab, Charles R. Harrington, Nora Lemke, Claude M. Wischik, Franz Theuring, Boris Neumann, Dilyara Lauer, Mandy Magbagbeolu, Valeria Melis
Publikováno v:
The Journal of Biological Chemistry
Synapse loss is associated with motor and cognitive decline in multiple neurodegenerative disorders, and the cellular redistribution of tau is related to synaptic impairment in tauopathies, such as Alzheimer's disease and frontotemporal dementia. Her
Publikováno v:
The Journal of Biological Chemistry
The envelope glycoprotein, termed the spike protein, of severe acute respiratory syndrome coronavirus (SARS-CoV) is known to mediate viral entry. Similar to other class 1 viral fusion proteins, the heptad repeat regions of SARS-CoV spike are thought