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Publikováno v:
The International Journal of Neuropsychopharmacology. 17:2057-2067
Epigenetic mechanisms appear to play an important role in neurodevelopment. We investigated the effects of acute ethanol exposure on anxiety measures and function of histone deacetylases (HDAC) and DNA methyltransferases (DNMT) in the amygdala and be
Publikováno v:
The International Journal of Neuropsychopharmacology. 17:1995-2004
Synthetic glucocorticoid dexamethasone (DEX) is frequently used as a therapeutic agent to lessen the morbidity of chronic lung disease in premature infants. Previous studies suggested that neonatal DEX treatment altered brain development and cognitiv
Autor:
Feng Jin, Qihai Gong, Li-Sheng Li, Fei Li, Yue-Ming Ma, Jingshan Shi, Li-Na Wang, Hai Jin, Ya-Sha Xu
Publikováno v:
The International Journal of Neuropsychopharmacology. 17:871-881
Phosphodiesterase-5 (PDE5) inhibitors are predominantly used in the treatment of erectile dysfunction, and have been recently shown to have a potential therapeutic effect for the treatment of Alzheimer's disease (AD) through stimulation of nitric oxi
Autor:
S.F. Lisboa, Francisco Silveira Guimarães, A. C. Magesto, L. H. A. Camargo, Leonardo Barbosa Moraes Resstel
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
The present study investigated the effects of systemic or intra-dorsolateral periaqueductal gray (dlPAG) administration of CB1 agonists on behavioural changes induced in rats by predator (a live cat) exposure, a model of panic responses. Since nitric
Publikováno v:
The International Journal of Neuropsychopharmacology; Vol 17
International Journal of Neuropsychopharmacology
International Journal of Neuropsychopharmacology
The gastrointestinal hormone PYY(3-36) is a preferential Y2 neuropeptide Y (NPY) receptor agonist. Recent evidence indicates that PYY(3-36) acts on central dopaminergic pathways, but its influence on dopamine-dependent behaviours remains largely unkn
Autor:
Agata Siwek, Mariusz Papp, Magdalena Sowa-Kućma, Bartłomiej Pochwat, Gabriel Nowak, Urszula Doboszewska, Bernadeta Szewczyk, Wojciech Piekoszewski, Piotr Gruca
Publikováno v:
The International Journal of Neuropsychopharmacology. 17:393-405
Recent data suggests that the glutamatergic system is involved in the pathophysiology and treatment of major depressive disorder (MDD) and that the N-methyl-D-aspartate (NMDA) receptor is a potential target for antidepressant drugs. The magnesium ion
Autor:
Avril Pereira, Suresh Sundram, Peter Malcolm, Anthony Sugiharto-Winarno, Betty Zhang, George Fink
Publikováno v:
The International Journal of Neuropsychopharmacology. 15:1149-1160
Treatment resistance remains a major obstacle in schizophrenia, with antipsychotic drugs (APDs) being ineffective in about one third of cases. Poor response to standard therapy leaves the APD clozapine as the only effective treatment for many patient
Autor:
Lindsey N. Burns, Devon L. Graham, Charles V. Vorhees, Michael T. Williams, Tori L. Schaefer, Amanda A. Braun, Curtis E. Grace, Robyn M. Amos-Kroohs, Matthew R. Skelton
Publikováno v:
The International Journal of Neuropsychopharmacology. 15:811-824
Previous findings showed allocentric and egocentric learning deficits in rats after MDMA treatment from postnatal days (PD) 11-20 but not after treatment from PD 1-10. Shorter treatment periods (PD 1-5, 6-10, 11-15, or 16-20) resulted in allocentric
Publikováno v:
The International Journal of Neuropsychopharmacology. 13:747-757
Post traumatic stress disorder (PTSD) is a chronic anxiety disorder initiated by an intensely threatening, traumatic event. There is a great need for more efficacious pharmacotherapy and preventive treatments for PTSD. In animals, corticotropin-relea
Autor:
Hyun Yu, Gyung Ah Jung, Hee Young Lee, Myoung Suk Seo, Hong Geun Park, Won Je Jeon, Se Hyun Kim, Unggu Kang, Yong Sik Kim
Publikováno v:
The International Journal of Neuropsychopharmacology. 11
Haloperidol, a classical antipsychotic drug, affects the extracellular signal-regulated kinase (ERK) pathway in the brain. However, findings are inconsistent and the mechanism by which haloperidol regulates ERK is poorly understood. Therefore, we exa