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pro vyhledávání: '"DeMeo, Dawn"'
Autor:
Tan, Lu, Perez, Juan, Mela, Marianna, Miranda, Elena, Burling, Keith, Rouhani, Farshid N, Demeo, Dawn L, Haq, Imran, Irving, James, Ordóñez, Adriana, Dickens, Jennifer, Brantly, Mark L, Marciniak, Stefan J., Alexander, Graeme, Gooptu, Bibekbrata, Lomas, David A.
Publikováno v:
The International Journal of Biochemistry & Cell Biology
Tan, L, Perez, J, Mela, M, Miranda, E, Burling, K, Rouhani, F N, Demeo, D L, Haq, I, Irving, J, Ordóñez, A, Dickens, J, Brantly, M L, Marciniak, S J, Alexander, G, Gooptu, B & Lomas, D A 2015, ' Characterising the association of latency with α1-antitrypsin polymerisation using a novel monoclonal antibody ', International Journal of Biochemistry and Cell Biology, vol. 58, pp. 81-91 . https://doi.org/10.1016/j.biocel.2014.11.005
Tan, L, Perez, J, Mela, M, Miranda, E, Burling, K, Rouhani, F N, Demeo, D L, Haq, I, Irving, J, Ordóñez, A, Dickens, J, Brantly, M L, Marciniak, S J, Alexander, G, Gooptu, B & Lomas, D A 2015, ' Characterising the association of latency with α1-antitrypsin polymerisation using a novel monoclonal antibody ', International Journal of Biochemistry and Cell Biology, vol. 58, pp. 81-91 . https://doi.org/10.1016/j.biocel.2014.11.005
α1-Antitrypsin is primarily synthesised in the liver, circulates to the lung and protects pulmonary tissues from proteolytic damage. The Z mutant (Glu342Lys) undergoes inactivating conformational change and polymerises. Polymers are retained within