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Autor:
Tatyana Rudina, Chhedi Lal Gupta, Sorina Grisaru-Granovsky, Rachel Bar‐ Shavit, Jeetendra Kumar Nag, Daria Kozlova, Liat Zakar, Myriam Maoz
Publikováno v:
The FASEB Journal. 34:15701-15717
While the involvement of protease-activated receptors (PARs) in the physiological regulation of human placenta development, as in tumor biology, is recognized, the molecular pathway is unknown. We evaluated the impact of PAR1 and PAR2 function in cyt
Publikováno v:
FASEB J
Although the innate immune receptor protein, Receptor for Advanced Glycation End products (RAGE), has been extensively studied, there has been renewed interest in RAGE for its potential role in sepsis, along with a host of other inflammatory diseases
Autor:
Hideaki Nishihara, Eric V. Shusta, Sasha Soldati, Britta Engelhardt, Fabien Gosselet, Sylvain Perriot, Amandine Mathias, Takashi Kanda, Renaud Du Pasquier, Fumitaka Shimizu, Benjamin D. Gastfriend, Yasuteru Sano, Sean P. Palecek
Publikováno v:
FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2020, 34 (12), pp.16693-16715. ⟨10.1096/fj.202001507RR⟩
Nishihara, Hideaki; Gastfriend, Benjamin D; Soldati, Sasha; Perriot, Sylvain; Mathias, Amandine; Sano, Yasuteru; Shimizu, Fumitaka; Gosselet, Fabien; Kanda, Takashi; Palecek, Sean P; Du Pasquier, Renaud; Shusta, Eric V; Engelhardt, Britta (2020). Advancing human induced pluripotent stem cell-derived blood-brain barrier models for studying immune cell interactions. FASEB journal, 34(12), pp. 16693-16715. Federation of American Societies for Experimental Biology 10.1096/fj.202001507RR
FASEB journal, vol. 34, no. 12, pp. 16693-16715
The FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2020, 34 (12), pp.16693-16715. ⟨10.1096/fj.202001507RR⟩
Nishihara, Hideaki; Gastfriend, Benjamin D; Soldati, Sasha; Perriot, Sylvain; Mathias, Amandine; Sano, Yasuteru; Shimizu, Fumitaka; Gosselet, Fabien; Kanda, Takashi; Palecek, Sean P; Du Pasquier, Renaud; Shusta, Eric V; Engelhardt, Britta (2020). Advancing human induced pluripotent stem cell-derived blood-brain barrier models for studying immune cell interactions. FASEB journal, 34(12), pp. 16693-16715. Federation of American Societies for Experimental Biology 10.1096/fj.202001507RR
FASEB journal, vol. 34, no. 12, pp. 16693-16715
The FASEB Journal
International audience; Human induced pluripotent stem cell (hiPSC)-derived blood-brain barrier (BBB) models established to date lack expression of key adhesion molecules involved in immune cell migration across the BBB in vivo. Here, we introduce th
Autor:
Seung Pil Yun, Kyung Seob Lim, Mu Seog Choe, Han Cheol Yeo, Woochul Chang, Chang Min Bae, Ho Jae Han, Kyung-min Baek, In-Sik Shin, Min Young Lee, Joong Sun Kim
Publikováno v:
The FASEB Journal. 34:16464-16475
Every year, hundreds of thousands of people die because of metastatic brain cancer. Most metastatic cancer research uses 2D cell culture or animal models, but they have a few limitations, such as difficulty reproducing human tissue structures. This s
Autor:
Qian Song, Hui Zhen, Zhonghong Cao, Bosheng Zhao, Mingyue Zheng, Qiuxiang Pang, Hongkuan Deng, Zuoqing Yuan
Publikováno v:
The FASEB Journal. 34:16567-16580
The growth and differentiation of neurons are critical events in the establishment of proper neuron connectivity and function. Planarians have a remarkable ability to completely regenerate a functional nervous system from a pluripotent stem cell popu
Autor:
Ritu Mishra, Kaitlyn M. Eckert, Carole R. Mendelson, Yaqin Yu, Lu Gao, Jeffrey G. McDonald, Jingfei Chen
Publikováno v:
The FASEB Journal. 34:16243-16261
Our previous research revealed that steroid receptor coactivators (Src)-1 and -2 serve a critical cooperative role in production of parturition signals, surfactant protein A and platelet-activating factor, by the developing mouse fetal lung (MFL). To
Publikováno v:
FASEB J
Estrogen receptor alpha (ERα) is a ligand-dependent transcription regulator, containing two transactivation functional domains, AF-1 and AF-2. The selective estrogen receptor modulators (SERMs), including 4-hydroxytamoxifen (4OHT), activate AF-1 pre
Autor:
Ying Zhang, Hei Man Chow, Kaiyu Xu, Lianwei Li, Zhanshan (Sam) Ma, Zhang Z, Karl Herrup, Jiali Li
Publikováno v:
The FASEB Journal. 34:16364-16382
5-hydroxymethylcytosine (5hmC) is an intermediate stage of DNA de-methylation. Its location in the genome also serves as an important regulatory signal for many biological processes and its levels change significantly with the etiology of Alzheimer's
Autor:
Christiane E. Olivero, Nadya Dimitrova
Publikováno v:
The FASEB Journal
Long noncoding RNAs (lncRNAs) have emerged as key regulators in a variety of cellular processes that influence disease states. In particular, many lncRNAs are genetically or epigenetically deregulated in cancer. However, whether lncRNA alterations ar
Autor:
Yuhong Chen, Xiaohua Chen, Guomin Huang, Xuetian Zhang, Ruowei Su, Feng Long, Hongying Yang, Caipeng Xu, Hong Zhang, Jing Wang, Cuixia Di
Publikováno v:
The FASEB Journal. 34:15647-15658
Poly (rC)-binding protein 1 (PCBP1), an RNA- or DNA-binding protein with a relative molecular weight of 38 kDa, which is characterized by downregulation in many cancer types. Numerous cases have indicated that PCBP1 could be considered as a tumor sup