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Publikováno v:
The FASEB Journal. 34:13993-14005
Many factors are involved in the process of nerve regeneration. Understanding the mechanisms regarding how these factors promote an efficient remyelination is crucial to deciphering the molecular and cellular processes required to promote nerve repai
Autor:
Monica I. Masana, Moisés A. Rivera-Bermúdez, Margarita L. Dubocovich, Randall L. Hudson, David J. Earnest, Martha U. Gillette, Matthew J. Gerdin
Publikováno v:
The FASEB Journal. 18:1646-1656
The hormone melatonin phase shifts circadian rhythms generated by the mammalian biological clock, the suprachiasmatic nucleus (SCN) of the hypothalamus, through activation of G protein-coupled MT2 melatonin receptors. This study demonstrated that pre
Autor:
Esperanza Ortega, Jesús M. Torres
Publikováno v:
The FASEB Journal. 17:1428-1433
The enzyme 5alpha-reductase (5alpha-R) is present in many mammalian tissues, including the brain. The physiological importance of 5alpha-R in the brain derives from its capability to convert testosterone (T) to a more potent androgen, dihydrotestoste
Publikováno v:
The FASEB Journal. 17:1-23
N-methyl-D-aspartate (NMDA) receptors for the central neurotransmitter l-glutamate (Glu) have been shown to be present in both osteoblasts and osteoclasts. Sustained exposure to the NMDA channel antagonist dizocilpine (MK-801) significantly prevented
Publikováno v:
The FASEB Journal. 16:1861-1868
The peroxisome proliferator-activated receptor (PPAR) is a nuclear receptor whose activation regulates metabolism and inflammation. Recent data indicate that the zinc finger transcription factor early growth response gene-1 (Egr-1) acts as a master s
Autor:
Yoshiyuki Hattori, Babrbara Pisano, Prabal K. Chatterjee, Helder Mota-Filipe, Christoph Thiemermann, Salvatore Cuzzocrea, Michelle C. McDonald, Nicole S. Wayman
Publikováno v:
The FASEB Journal. 16:1027-1040
This study was designed to investigate the effects of various chemically distinct activators of PPAR-gamma and PPAR-alpha in a rat model of acute myocardial infarction. Using Northern blot analysis and RT-PCR in samples of rat heart, we document the
Autor:
Ángeles Álvarez, Sales Ibiza, Carlos Hernández, Alberto Álvarez‐Barrientos, Juan V. Esplugues, Sara Calatayud
Publikováno v:
The FASEB Journal. 20:2396-2398
Gastric mucosal inflammation causes hypergastrinemia, and gastrin receptors have been detected in several leukocyte types. We have analyzed whether gastrin affects the leukocyte-endothelial cell interactions in vivo by monitoring leukocyte rolling, a
Publikováno v:
The FASEB Journal. 20:1748-1750
Macrophage migration inhibitory factor (MIF) acts intracellularly to counteract the angiotensin (ANG) II type 1 receptor (AT1-R)-mediated chronotropic effect of ANG II in hypothalamic neurons, an effect mediated by the thiol-protein oxidoreductase (T
Autor:
Genaro G. Ortiz, Jose M. Fernandez-Santos, Ines Martin-Lacave, Mario Delgado, Juan M. Guerrero, Rosa P. Gomariz, Juan R. Calvo, David Pozo
Publikováno v:
Europe PubMed Central
In the present work we analyze by reverse transcription, polymerase chain reaction, cDNA cloning, and sequence analysis the expression of membrane melatonin receptors in rat thymus and spleen. Results show, for the first time, that the melatonin rece
Autor:
Charles Steenbergen, Khalid Amin, Paul R. Hanlon, Elizabeth Murphy, Murat O. Arcasoy, Gary L. Wright
Publikováno v:
The FASEB Journal. 18:1031-1033
Erythropoietin (EPO), the principal hematopoietic cytokine that regulates mammalian erythropoiesis, exhibits diverse cellular effects in non-hematopoietic tissues. The physiologic functions of EPO are mediated by its specific cell-surface receptor EP