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Autor:
Yirui Wang, Jiahui Ni, Hai-Dong Li, Hua Zhou, Sulin Zhang, Mingyue Zheng, Lixin Liu, Yan You, Hui Hou, Xiaoyan Shen, Guize Feng, Wei-Lian Bao, Xu Wang, Weixing Shen
Publikováno v:
The EMBO Journal. 40
Altered intestinal microbial composition promotes intestinal barrier dysfunction and triggers the initiation and recurrence of inflammatory bowel disease (IBD). Current treatments for IBD are focused on control of inflammation rather than on maintain
Autor:
Jörn Coers, Mary S Dickinson
Publikováno v:
EMBO J
Altered intestinal microbial composition promotes intestinal barrier dysfunction and triggers the initiation and recurrence of inflammatory bowel disease (IBD). Current treatments for IBD are focused on control of inflammation rather than on maintain
Autor:
Daniela Pankova, Eduard Willms, David Cano-Rodriguez, Eric O'Neill, Anna M. Grawenda, Alex von Kriegsheim, Sander C. Steenbeek, Matthew J.A. Wood, Christiana Kartsonaki, Nikola Vlahov, Maria Laura Tognoli, Jacco van Rheenen, Michael Eyres, Simon Scrace, Marianne G. Rots
Publikováno v:
The EMBO Journal
The EMBO Journal, 40(20):107680. Wiley
The EMBO Journal, 40(20):107680. Wiley
Cell plasticity is a crucial hallmark leading to cancer metastasis. Upregulation of Rho/ROCK pathway drives actomyosin contractility, protrusive forces, and contributes to the occurrence of highly invasive amoeboid cells in tumors. Cancer stem cells
Autor:
Mindong Ren, Thomas A. Neubert, Colin K.L. Phoon, Hediye Erdjument-Bromage, Michael Schlame, Yang Xu
Publikováno v:
EMBO J
Mitochondrial cristae are extraordinarily crowded with proteins, which puts stress on the bilayer organization of lipids. We tested the hypothesis that the high concentration of proteins drives the tafazzin‐catalyzed remodeling of fatty acids in ca
Autor:
Houjiang Zhou, Paul L. Appleton, Miroslav Novak, Florian Weiland, Rachel Toth, Vasiliki Pantazi, Michael E Morgan, Barbara N. Borsos, John Rouse, Meghan Slean, Taran Khanam, Tibor Pankotai, Thomas D. Carroll, Ivan Muñoz
Publikováno v:
The EMBO Journal
Mutations in the gene encoding the CDKL5 kinase are among the most common genetic causes of childhood epilepsy and can also give rise to the severe neurodevelopmental condition CDD (CDKL5 deficiency disorder). Despite its importance for human health,
Autor:
Lorenzo Galluzzi, Hans-Uwe Simon, Augustine M.K. Choi, Qing Zhong, Patrice Codogno, Junying Yuan, Alexandra Stolz, Zvulun Elazar, Eeva-Liisa Eskelinen, Douglas R. Green, José Manuel Bravo-San Pedro, David A. Gewirtz, Anne Simonsen, Sharon A. Tooze, Frank Madeo, María Isabel Colombo, Terje Johansen, Ravi K. Amaravadi, Giulia Petroni, Nicholas T. Ktistakis, Luca Scorrano, Marja Jäättelä, David C. Rubinsztein, Laura Santambrogio, Ivan Dikic, Kay F. Macleod, Kevin M. Ryan, Claudine Kraft, Gian Maria Fimia, Charleen T. Chu, Jennifer Martinez, Carlos López-Otín, Junichi Sadoshima, Gábor Juhász, Vassiliki Karantza, Malene Hansen, Zhenyu Yue, Ken Cadwell, Ana Maria Cuervo, Francesco Cecconi, Mary E. Choi, Eric H. Baehrecke, Patricia Boya, Vojo Deretic, Nektarios Tavernarakis, Alicia Meléndez, Josef M. Penninger, Mauro Piacentini, Tamotsu Yoshimori, Fulvio Reggiori, Sharad Kumar, Andrea Ballabio, Anna Katharina Simon, Federico Pietrocola, Rushika M. Perera, Guido Kroemer, Christian Münz, Noboru Mizushima, Daniel J. Klionsky
Publikováno v:
The EMBO Journal
Klionsky, D J, Petroni, G, Amaravadi, R K, Baehrecke, E H, Ballabio, A, Boya, P, Bravo-San Pedro, J M, Cadwell, K, Cecconi, F, Choi, A M K, Choi, M E, Chu, C T, Codogno, P, Colombo, MI, Cuervo, A M, Deretic, V, Dikic, I, Elazar, Z, Eskelinen, E L, Fimia, G M, Gewirtz, D A, Green, D R, Hansen, M, Jäättelä, M, Johansen, T, Juhász, G, Karantza, V, Kraft, C, Kroemer, G, Ktistakis, N T, Kumar, S, Lopez-Otin, C, Macleod, K F, Madeo, F, Martinez, J, Meléndez, A, Mizushima, N, Münz, C, Penninger, J M, Perera, RM, Piacentini, M, Reggiori, F, Rubinsztein, D C, Ryan, KM, Sadoshima, J, Santambrogio, L, Scorrano, L, Simon, H U, Simon, A K, Simonsen, A, Stolz, A, Tavernarakis, N, Tooze, S A, Yoshimori, T, Yuan, J, Yue, Z, Zhong, Q, Galluzzi, L & Pietrocola, F 2021, ' Autophagy in major human diseases ', EMBO Journal, vol. 40, e108863 . https://doi.org/10.15252/embj.2021108863
Scopus
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
Klionsky, D J, Petroni, G, Amaravadi, R K, Baehrecke, E H, Ballabio, A, Boya, P, Bravo-San Pedro, J M, Cadwell, K, Cecconi, F, Choi, A M K, Choi, M E, Chu, C T, Codogno, P, Colombo, M I, Cuervo, A M, Deretic, V, Dikic, I, Elazar, Z, Eskelinen, E-L, Fimia, G M, Gewirtz, D A, Green, D R, Hansen, M, Jäättelä, M, Johansen, T, Juhász, G, Karantza, V, Kraft, C, Kroemer, G, Ktistakis, N T, Kumar, S, Lopez-Otin, C, Macleod, K F, Madeo, F, Martinez, J, Meléndez, A, Mizushima, N, Münz, C, Penninger, J M, Perera, R M, Piacentini, M, Reggiori, F, Rubinsztein, D C, Ryan, K M, Sadoshima, J, Santambrogio, L, Scorrano, L, Simon, H-U, Simon, A K, Simonsen, A, Stolz, A, Tavernarakis, N, Tooze, S A, Yoshimori, T, Yuan, J, Yue, Z, Zhong, Q, Galluzzi, L & Pietrocola, F 2021, ' Autophagy in major human diseases ', The EMBO Journal, vol. 40, no. 19, pp. e108863 . https://doi.org/10.15252/embj.2021108863
Klionsky, Daniel J; Petroni, Giulia; Amaravadi, Ravi K; Baehrecke, Eric H; Ballabio, Andrea; Boya, Patricia; Bravo-San Pedro, José Manuel; Cadwell, Ken; Cecconi, Francesco; Choi, Augustine M K; Choi, Mary E; Chu, Charleen T; Codogno, Patrice; Colombo, Maria Isabel; Cuervo, Ana Maria; Deretic, Vojo; Dikic, Ivan; Elazar, Zvulun; Eskelinen, Eeva-Liisa; Fimia, Gian Maria; ... (2021). Autophagy in major human diseases. The EMBO journal, 40(19), e108863. EMBO Press 10.15252/embj.2021108863
EMBO Reports
Klionsky, D J, Petroni, G, Amaravadi, R K, Baehrecke, E H, Ballabio, A, Boya, P, Bravo-San Pedro, J M, Cadwell, K, Cecconi, F, Choi, A M K, Choi, M E, Chu, C T, Codogno, P, Colombo, MI, Cuervo, A M, Deretic, V, Dikic, I, Elazar, Z, Eskelinen, E L, Fimia, G M, Gewirtz, D A, Green, D R, Hansen, M, Jäättelä, M, Johansen, T, Juhász, G, Karantza, V, Kraft, C, Kroemer, G, Ktistakis, N T, Kumar, S, Lopez-Otin, C, Macleod, K F, Madeo, F, Martinez, J, Meléndez, A, Mizushima, N, Münz, C, Penninger, J M, Perera, RM, Piacentini, M, Reggiori, F, Rubinsztein, D C, Ryan, KM, Sadoshima, J, Santambrogio, L, Scorrano, L, Simon, H U, Simon, A K, Simonsen, A, Stolz, A, Tavernarakis, N, Tooze, S A, Yoshimori, T, Yuan, J, Yue, Z, Zhong, Q, Galluzzi, L & Pietrocola, F 2021, ' Autophagy in major human diseases ', EMBO Journal, vol. 40, e108863 . https://doi.org/10.15252/embj.2021108863
Scopus
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
Klionsky, D J, Petroni, G, Amaravadi, R K, Baehrecke, E H, Ballabio, A, Boya, P, Bravo-San Pedro, J M, Cadwell, K, Cecconi, F, Choi, A M K, Choi, M E, Chu, C T, Codogno, P, Colombo, M I, Cuervo, A M, Deretic, V, Dikic, I, Elazar, Z, Eskelinen, E-L, Fimia, G M, Gewirtz, D A, Green, D R, Hansen, M, Jäättelä, M, Johansen, T, Juhász, G, Karantza, V, Kraft, C, Kroemer, G, Ktistakis, N T, Kumar, S, Lopez-Otin, C, Macleod, K F, Madeo, F, Martinez, J, Meléndez, A, Mizushima, N, Münz, C, Penninger, J M, Perera, R M, Piacentini, M, Reggiori, F, Rubinsztein, D C, Ryan, K M, Sadoshima, J, Santambrogio, L, Scorrano, L, Simon, H-U, Simon, A K, Simonsen, A, Stolz, A, Tavernarakis, N, Tooze, S A, Yoshimori, T, Yuan, J, Yue, Z, Zhong, Q, Galluzzi, L & Pietrocola, F 2021, ' Autophagy in major human diseases ', The EMBO Journal, vol. 40, no. 19, pp. e108863 . https://doi.org/10.15252/embj.2021108863
Klionsky, Daniel J; Petroni, Giulia; Amaravadi, Ravi K; Baehrecke, Eric H; Ballabio, Andrea; Boya, Patricia; Bravo-San Pedro, José Manuel; Cadwell, Ken; Cecconi, Francesco; Choi, Augustine M K; Choi, Mary E; Chu, Charleen T; Codogno, Patrice; Colombo, Maria Isabel; Cuervo, Ana Maria; Deretic, Vojo; Dikic, Ivan; Elazar, Zvulun; Eskelinen, Eeva-Liisa; Fimia, Gian Maria; ... (2021). Autophagy in major human diseases. The EMBO journal, 40(19), e108863. EMBO Press 10.15252/embj.2021108863
EMBO Reports
Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently
Autor:
Mathieu Hubert, Jérémy Dufloo, Rémy Robinot, Hugo Mouquet, Olivier Schwartz, Ludivine Grzelak, Nell Saunders, Elodie Bishop, Françoise Porrot, Delphine Planas, Maaran Michael Rajah, Julian Buchrieser, Lisa A. Chakrabarti, Marija Zivaljic, Alice Bongers, Stacy Gellenoncourt, Florence Guivel-Benhassine, Cyril Planchais
Publikováno v:
The EMBO Journal
EMBO Journal
EMBO Journal, EMBO Press, 2021, 40 (24), pp.e108944. ⟨10.15252/embj.2021108944⟩
EMBO Journal, 2021, 40 (24), pp.e108944. ⟨10.15252/embj.2021108944⟩
EMBO Journal
EMBO Journal, EMBO Press, 2021, 40 (24), pp.e108944. ⟨10.15252/embj.2021108944⟩
EMBO Journal, 2021, 40 (24), pp.e108944. ⟨10.15252/embj.2021108944⟩
Severe COVID‐19 is characterized by lung abnormalities, including the presence of syncytial pneumocytes. Syncytia form when SARS‐CoV‐2 spike protein expressed on the surface of infected cells interacts with the ACE2 receptor on neighboring cell
Autor:
Ida Rishal, Indrek Koppel, Riki Kawaguchi, Ella Doron-Mandel, Ofri Abraham, Jeffery L. Twiss, Courtney N Buchanan, Jan Kadlec, Didi-Andreas Song, Stefanie Alber, Pabitra K. Sahoo, Rebecca Haffner-Krausz, Pierluigi Di Matteo, Dalia Gordon, Eitan Erez Zahavi, Alma L. Burlingame, Giovanni Coppola, Terika P. Smith, Juan A. Oses-Prieto, Pavel Jungwirth, Shifra Ben-Dor, Agostina Di Pizio, Nataliya Okladnikov, Mike Fainzilber
Publikováno v:
The EMBO Journal
Nucleolin is a multifunctional RNA Binding Protein (RBP) with diverse subcellular localizations, including the nucleolus in all eukaryotic cells, the plasma membrane in tumor cells, and the axon in neurons. Here we show that the glycine arginine rich
Autor:
Patrick J. Hrdlicka, Steven A. Roberts, Amanda V. Albrecht, Peng Mao, Raymond G Emehiser, Bastian Stark, Kaitlynne A. Bohm, John J. Wyrick, Smitha Sivapragasam, Gregory M.K. Poon
Publikováno v:
EMBO J
Somatic mutations in DNA-binding sites for CCCTC-binding factor (CTCF) are significantly elevated in many cancers. Prior analysis has suggested that elevated mutation rates at CTCF-binding sites in skin cancers are a consequence of the CTCF-cohesin c
Autor:
Shengjie Zhang, Lingjun Li, Fengfei Ma, Peng Liu, Min Ma, Kristine Donahue, Gui Ma, Fabao Liu, Yidan Wang, Sunduz Keles, Wei Xu, Chenxi Jia, Irene M. Ong, Ang Gao
Publikováno v:
The EMBO Journal. 40
The pyruvate kinase M2 isoform (PKM2) is preferentially expressed in cancer cells to regulate anabolic metabolism. Although PKM2 was recently reported to regulate lipid homeostasis, the molecular mechanism remains unclear. Herein, we discovered an ER