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Autor:
Peter J. Peters, Bart L. Haagmans, Nathalie Groen, Jelte van der Vaart, Debby Schipper, Jeroen Demmers, Kèvin Knoops, Tim I Breugem, Hans Duimel, Hans Clevers, Marion Koopmans, Mauro J. Muraro, Samra Riesebosch, Joep Beumer, Karel Bezstarosti, Georges M. G. M. Verjans, Anna Z Mykytyn, Mart M. Lamers, Raimond B. G. Ravelli, Charlotte D. Koopman
Publikováno v:
EMBO Journal. Nature Publishing Group
The EMBO Journal
The Embo Journal, 40(5):105912. Wiley
EMBO Journal, 40(5):e105912. Wiley-Blackwell
The EMBO Journal
The Embo Journal, 40(5):105912. Wiley
EMBO Journal, 40(5):e105912. Wiley-Blackwell
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) causes coronavirus disease 2019 (COVID‐19), which may result in acute respiratory distress syndrome (ARDS), multiorgan failure, and death. The alveolar epithelium is a major target of
Autor:
Michal Neeman, Hilah Gal, Tal Biron-Shental, Ron Rotkopf, Sima Stroganov, Keren Tzadikevitch-Geffen, Sameh A. Youssef, Ezra Vadai, Marina Lysenko, Valery Krizhanovsky, Alain de Bruin
Publikováno v:
EMBO Journal, 38(18):100849. Wiley
The EMBO Journal
EMBO Journal, 38(18). Nature Publishing Group
EMBO J
The EMBO Journal
EMBO Journal, 38(18). Nature Publishing Group
EMBO J
The placenta is an autonomous organ that maintains fetal growth and development. Its multinucleated syncytiotrophoblast layer, providing fetal nourishment during gestation, exhibits characteristics of cellular senescence. We show that in human placen
Autor:
Egbert F. Smit, Maarten van der Linden, Emile E. Voest, Sander J. Tans, Fleur Weeber, Luc Teeven, Joep de Ligt, Linde Meyaard, Edwin Cuppen, G. Johan A. Offerhaus, Johanna F. Dekkers, Norman Sachs, Peter J. Peters, Sylvia F. Boj, Gimano D. Amatngalim, Domenique D. Zomer-van Ommen, Emilio Ramos, Matthijs F.M. van Oosterhout, Alexander van Oudenaarden, Coline H.M. van Moorsel, Robert G.J. Vries, Marco C. Viveen, Eduardo P. Olimpio, Natalie Proost, Arne Van Hoeck, Anne C. Rios, Dominique J Wiener, Krijn K. Dijkstra, Frank E. J. Coenjaerts, Guizela Huelsz-Prince, Lena Böttinger, Harry Begthel, Marieke van de Ven, Jos Jonkers, Jeroen Korving, Sepideh Derakhshan, Sridevi Jaksani, Anna Lyubimova, Louis Bont, Cornelis K. van der Ent, Angelos Papaspyropoulos, Jeroen S. van Zon, Nino Iakobachvili, Hans Clevers, Dymph Klay, Inha Heo, Kuldeep Kumawat, Jeffrey M. Beekman
Publikováno v:
EMBO Journal, 38(4). Nature Publishing Group
The Embo Journal, 38(4):100300. Wiley
The Embo Journal, 38(4):100300. Wiley
Organoids are self-organizing 3D structures grown from stem cells that recapitulate essential aspects of organ structure and function. Here, we describe a method to establish long-term-expanding human airway organoids from broncho-alveolar resections
Publikováno v:
EMBO JOURNAL
N-cadherin-mediated adhesion is essential for maintaining the tissue architecture and stem cell niche in the developing neocortex. N-cadherin expression level is precisely and dynamically controlled throughout development; however, the underlying reg
Autor:
Souji Ibuka, Masaru Ishii, Yoshinori Kagawa, Shinsuke Fujii, Shinji Matsumoto, Akira Sato, Akira Kikuchi
Publikováno v:
The EMBO Journal. 33:702-718
Growth factor-dependent epithelial morphological changes and proliferation are essential for the formation of tubular structures, but the underlying molecular mechanisms are poorly understood. Co-stimulation with Wnt3a and epidermal growth factor (Wn
Publikováno v:
The EMBO Journal. 33:501-511
Lysosomal Ca2+ homeostasis is implicated in disease and controls many lysosomal functions. A key in understanding lysosomal Ca2+ signaling was the discovery of the two-pore channels (TPCs) and their potential activation by NAADP. Recent work conclude
Autor:
Michal Schwartz, Kuti Baruch
Publikováno v:
The EMBO Journal; Vol 33
Inflammation is an integral part of the body's physiological repair mechanism, unless it remains unresolved and becomes pathological, as evident in the progressive nature of neurodegeneration. Based on studies from outside the central nervous system
Autor:
Dominique Meunier, Christina Humer, Mirjam A. Moser, Simon Weissmann, Gerald Brosch, Christian Seiser, Carina Fischer, Mircea Winter, Katharina Mattes, Patrick Matthias, Beate M. Lichtenberger, Reinhard Brunmeir, Georg Machat, Maria Sibilia, Tina Meischel, Christina Murko
Publikováno v:
The EMBO Journal. 32:3176-3191
The histone deacetylases HDAC1 and HDAC2 remove acetyl moieties from lysine residues of histones and other proteins and are important regulators of gene expression. By deleting different combinations of Hdac1 and Hdac2 alleles in the epidermis, we re
Large cargo transport by nuclear pores: implications for the spatial organization of FG-nucleoporins
Publikováno v:
The EMBO Journal. 32:3220-3230
Nuclear pore complexes (NPCs) mediate cargo traffic between the nucleus and the cytoplasm of eukaryotic cells. Nuclear transport receptors (NTRs) carry cargos through NPCs by transiently binding to phenylalanine-glycine (FG) repeats on intrinsically
SNAIL and miR-34a feed-forward regulation of ZNF281/ZBP99 promotes epithelial-mesenchymal transition
Publikováno v:
The EMBO Journal. 32:3079-3095
Here, we show that expression of ZNF281/ZBP-99 is controlled by SNAIL and miR-34a/b/c in a coherent feed-forward loop: the epithelial–mesenchymal transition (EMT) inducing factor SNAIL directly induces ZNF281 transcription and represses miR-34a/b/c