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Autor:
Katharina F. Sonnen, Claudia Y. Janda
Publikováno v:
The Biochemical journal, 478(23), 4045-4070. Portland Press Ltd.
Biochemical Journal
Biochemical Journal
In multicellular organisms, cellular behaviour is tightly regulated to allow proper embryonic development and maintenance of adult tissue. A critical component in this control is the communication between cells via signalling pathways, as errors in i
Publikováno v:
Biochemical Journal
Cullin ubiquitin ligases drive replisome disassembly during DNA replication termination. In worm, frog and mouse cells, CUL2LRR1 is required to ubiquitylate the MCM7 subunit of the CMG helicase. Here, we show that cullin ligases also drive CMG-MCM7 u
Publikováno v:
The Biochemical journal. 477(20)
Renal epithelial cells regulate the destructive activity of macrophages and participate in the progression of kidney diseases. Critically, the Unfolded Protein Response (UPR), which is activated in renal epithelial cells in the course of kidney injur
Autor:
Shen-Hsing Hsu, Ya-Chung Tian, Ming-Yang Chang, Li-Feng Chou, Yuh-Ju Sun, Chih-Wei Yang, Chen-Hsi Chu
Publikováno v:
The Biochemical journal. 477(21)
Leptospirosis is the most common zoonotic disease caused by pathogenic Leptospira, which is classified into three groups according to virulence. Its pathogenic and intermediate species contain leucine-rich repeat (LRR) proteins that are rarely expres
Autor:
Min Kyoung Kam, Jae-Won Huh, Dong-Seok Lee, Bokyung Kim, Hong Jun Lee, Young-Ho Park, Dong Gil Lee
Publikováno v:
The Biochemical journal. 477(23)
Alzheimer's disease (AD) is a neurodegenerative disease associated with the accumulation of amyloid-beta oligomers (AβO). Recent studies have demonstrated that mitochondria-specific autophagy (mitophagy) contributes to mitochondrial quality control
Autor:
Suresh V. Ambudkar, Sabrina Lusvarghi
Publikováno v:
Biochem J
P-glycoprotein (P-gp), an ATP-binding cassette transporter associated with multidrug resistance in cancer cells, is capable of effluxing a number of xenobiotics as well as anticancer drugs. The transport of molecules through the transmembrane (TM) re
Autor:
Linh Khanh Vo, Yuko Kamada-Futagami, Kazuki Oishi, Toshiharu Tsuzuki, Akinobu Honda, Masaharu Komatsu, Petros Kingstone Chigwechokha, Kazuhiro Shiozaki
Publikováno v:
The Biochemical journal. 476(21)
Edwardsiella tarda is a gram-negative bacterium causing significant economic losses to aquaculture. E. tarda possesses NanA sialidase which removes sialic acids from α2–3 sialo-glycoprotein of host cells. However, the relationship between NanA sia
Publikováno v:
The Biochemical journal. 476(21)
The tubular network of the endoplasmic reticulum (ER) is formed by connecting ER tubules through three-way junctions. Two classes of the conserved ER membrane proteins, atlastins and lunapark, have been shown to reside at the three-way junctions so f
Publikováno v:
The Biochemical journal. 476(19)
Nur77 is a transcription factor belonging to the NR4A subfamily of nuclear hormone receptors. Upon induction, Nur77 modulates the expression of its target genes and controls a variety of biological and pathophysiological processes. Prior research tha
Autor:
Indira Padmalayam, Nichole A. Tower, Yinfeng Zhang, Robert Bostwick, Ling Zhai, Catherine E. Scull, Lynn Rasmussen, David A. Schneider, Robert N. Hunter
Publikováno v:
Biochem J
Over the past two decades, ribosome biogenesis has emerged as an attractive target for cancer treatment. In this study, two high-throughput screens were used to identify ribosome biogenesis inhibitors. Our primary screen made use of the HaloTag selec