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Autor:
Cristina E. Requena, Guiomar Pérez-Moreno, Dolores González-Pacanowska, András Horváth, Beáta G. Vértessy, Luis M. Ruiz-Pérez, Antonio E. Vidal
Publikováno v:
The Biochemical journal. 473(17)
Decitabine (5-aza-2′-deoxycytidine, aza-dCyd) is an anti-cancer drug used clinically for the treatment of myelodysplastic syndromes and acute myeloid leukaemia that can act as a DNA-demethylating or genotoxic agent in a dose-dependent manner. On th
Autor:
Zsuzsa Kovacs, Axel Methner, Philipp Albrecht, Ann‑Kathrin Herrmann, Konstantinos Lefkimmiatis, Teresa Schacht
Publikováno v:
Europe PubMed Central
GPR39 is a G-protein-coupled zinc receptor that protects against diverse effectors of cell death. Its protective activity is mediated via constitutive activation of Gα13 and the RhoA pathway, leading to increased SRE (serum-response element)-depende
Publikováno v:
The Biochemical journal. 461(3)
siRNAs are short dsRNAs that mediate efficient target gene silencing in a sequence-specific manner. We previously developed a novel siRNA structure, called asiRNA (asymmetric siRNA), which alleviates the off-target effects associated with conventiona
Publikováno v:
The Biochemical journal. 449(3)
The ASC (apoptosis speck-like protein) is a key component of multimeric protein complexes that mediate inflammation and host defence. Comprising a PYD (Pyrin) domain and a CARD (caspase activation and recruitment domain), ASC functions downstream of
Publikováno v:
The Biochemical journal. 427(3)
Gli (glioma-associated oncogene homologue) proteins act as terminal effectors of the Hedgehog signalling pathway, which is implicated in the development of many human malignancies. Gli activation is important for cell proliferation and anti-apoptosis
Autor:
D. Grahame Hardie, Sarah Fogarty, Kevin A. Green, Simon A. Hawley, Nazan Saner, Kirsty J. Mustard
Publikováno v:
Biochemical Journal
Activation of AMPK (AMP-activated protein kinase) by phosphorylation at Thr172 is catalysed by at least two distinct upstream kinases, i.e. the tumour suppressor LKB1, and CaMKKbeta (Ca2+/calmodulin-dependent protein kinase kinase-beta). The sequence
Autor:
Annemieke Kolkman, H. Th. Marc Timmers, Albert J. R. Heck, W.W.M. Pim Pijnappel, Nga-Chi Lau, Klaas W. Mulder, Frederik M. A. van Schaik
Publikováno v:
The Biochemical journal. 422(3)
The Ccr4–Not complex is evolutionarily conserved and important for regulation of mRNA synthesis and decay. The composition of the yeast complex has been well described. Orthologues of the yeast Ccr4–Not components have been identified in human ce
Autor:
Sara Rodríguez-Acebes, Paloma de la Cueva, Robert B. Rawson, Carlos Fernández-Hernando, Javier Martínez-Botas, Antonio J. Ferruelo, Diego Gómez-Coronado, Miguel A. Lasunción
Publikováno v:
The Biochemical journal. 420(2)
Cholesterol homoeostasis is critical for cell viability and proliferation. The SREBP (sterol regulatory element-binding protein) pathway is crucial for the maintenance of cholesterol homoeostasis. This pathway is controlled by cholesterol and cholest
Publikováno v:
The Biochemical journal. 419(1)
ROCK (Rho-associated coiled-coil kinase) 2 is a member of the AGC kinase family that plays an essential role downstream of Rho in actin cytoskeleton assembly and contractility. The process of ROCK2 activation is complex and requires suppression of an
Publikováno v:
The Biochemical journal. 396(1)
Accumulating evidence indicates the potential role of actin cytoskeleton in facilitating the mitochondrial recruitment of various pro-apoptotic proteins from the cytosol to initiate apoptosis. In the present paper, we report the observation of the in