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Publikováno v:
Biochemical Journal
Cullin ubiquitin ligases drive replisome disassembly during DNA replication termination. In worm, frog and mouse cells, CUL2LRR1 is required to ubiquitylate the MCM7 subunit of the CMG helicase. Here, we show that cullin ligases also drive CMG-MCM7 u
Autor:
Linh Khanh Vo, Yuko Kamada-Futagami, Kazuki Oishi, Toshiharu Tsuzuki, Akinobu Honda, Masaharu Komatsu, Petros Kingstone Chigwechokha, Kazuhiro Shiozaki
Publikováno v:
The Biochemical journal. 476(21)
Edwardsiella tarda is a gram-negative bacterium causing significant economic losses to aquaculture. E. tarda possesses NanA sialidase which removes sialic acids from α2–3 sialo-glycoprotein of host cells. However, the relationship between NanA sia
Autor:
Davor Brinc, Yijing Yu, Eleftherios P. Diamandis, Ioannis Prassas, Panagiota Filippou, Sofia Farkona
Publikováno v:
The Biochemical journal. 474(14)
Human tissue kallikrein 9 (KLK9) is a member of the kallikrein-related family of proteases. Despite its known expression profile, much less is known about the functional roles of this protease and its implications in normal physiology and disease. We
Autor:
Mausumi Mazumdar, Dao-Wei Zhu, Diane Fournier, Christine Cadot, Sheng-Xiang Lin, Donald Poirier
Publikováno v:
The Biochemical journal. 424(3)
Oestradiol is a well-characterized sex hormone that stimulates breast cancer and other oestrogen-related diseases. 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) catalyses the last step in the synthesis of oestradiol and androstenediol in b
Publikováno v:
The Biochemical journal. 424(1)
The metalloproteinases TACE [tumour necrosis factor α-converting enzyme; also known as ADAM17 (a disintegrin and metalloproteinase 17)] and ADAM10 are the primary enzymes responsible for catalysing release of membrane-anchored proteins from the cell
Autor:
Jukka V. Lehtonen, Pauli Ollikka, Elina Jakobsson, Anne Jokilammi, Harri Hirvonen, Juha Aalto, Jukka Finne
Publikováno v:
The Biochemical journal. 405(3)
Endosialidase (endo-N-acetylneuraminidase) is a tailspike enzyme of bacteriophages specific for human pathogenic Escherichia coli K1, which specifically recognizes and degrades polySia (polysialic acid). polySia is also a polysaccharide of the capsul
Autor:
Christian Prante, Sylvia Schön, S. A. H. Müller, Joachim Kuhn, Thomas Brinkmann, Manuela Schöttler, Christian Götting, Knut Kleesiek, Jennifer Disse
Publikováno v:
The Biochemical journal. 394(Pt 1)
Human XT-I (xylosyltransferase I; EC 2.4.2.26) initiates the biosynthesis of the glycosaminoglycan linkage region and is a diagnostic marker of an enhanced proteoglycan biosynthesis. In the present study, we have investigated mutant enzymes of human
Autor:
Santosh Nigam, Hridayesh Prakash, Ganchimeg Ishdorj, Sandhya Singh, Shakti Sahi, Roberto Ciccoli, Maria-Patapia Zafiriou, Johan L.F. Kock
Publikováno v:
The Biochemical journal. 390(Pt 3)
Cyclo-oxygenases-1/2 (COX-1/2) catalyse the oxygenation of AA (arachidonic acid) and related polyunsaturated fatty acids to endoperoxide precursors of prostanoids. COX-1 is referred to as a constitutive enzyme involved in haemostasis, whereas COX-2 i
Publikováno v:
The Biochemical journal. 340
Xenobiotic metabolizing enzymes in the olfactory epithelium have been suggested to catalyse inactivation and facilitate elimination of odorants. We report here the molecular cloning and functional characterization of a human olfactory UDP-glucuronosy
Autor:
Zhongheng Tu, M. W. Anders
Publikováno v:
The Biochemical journal. 336
Glutamate–cysteine ligase (GLCL) catalyses the rate-limiting step in glutathione biosynthesis. To identify cysteine residues in GLCL that are involved in its activity, eight conserved cysteine residues in human GLCL catalytic subunit (hGLCLC) were