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Publikováno v:
The Annals of Thoracic Surgery. 81:1715-1719
Background Levosimendan is a potent inotropic and vasodilator drug used in the treatment of decompensated heart failure. There is no study on in vitro effects of levosimendan in human isolated arteries. Methods We investigated the effect of levosimen
Autor:
Peter B. Barker, Michael V. Johnston, Jason A. Williams, Mary E. Blue, Juan C. Troncoso, Lisa E. Kratz, Mary S. Lange, William A. Baumgartner, Torin P. Fitton, Mahaveer Degaonkar, Vincent L. Gott, Christopher J. Barreiro
Publikováno v:
The Annals of Thoracic Surgery. 81:1593-1598
Background Studies have confirmed the neuroprotective effect of diazoxide in canines undergoing hypothermic circulatory arrest (HCA). A decreased N-acetyl-asparate:choline (NAA:Cho) ratio is believed to reflect the severity of neurologic injury. We d
Autor:
Denise Wozny, Thierry G. Mesana, Marc Ruel, Kathryn S. Williams, Fraser D. Rubens, Jacob Karsh, Rosalind S. Labow, Howard J. Nathan
Publikováno v:
The Annals of Thoracic Surgery. 79:655-665
Background Cardiopulmonary bypass (CPB) induces derangements in physiology characterized by activation of blood pathways that may contribute to multiorgan dysfunction. This trial addresses the efficacy of a biocompatible surface alone and in combinat
Autor:
Glen A. Laine, L. Maximilian Buja, Uwe Mehlhorn, Steven J. Allen, Hans J. Geissler, Karen L. Davis, Michael L. Brennan
Publikováno v:
The Annals of Thoracic Surgery. 72:1964-1969
Infarct size can be reduced by beta-blockade in acute myocardial ischemia. However it is unknown whether myocardial salvage is still effective when beta-blockade is limited to reperfusion.After initiation of cardiopulmonary bypass, 20 dogs were submi
Publikováno v:
The Annals of Thoracic Surgery. 70:602-608
Background . Both potassium channel openers and protein kinase C have been shown to independently elicit the myoprotective preconditioning response. However, the in vivo dependency between the two is unknown. Methods . Thirty-seven sheep were divided
Publikováno v:
The Annals of Thoracic Surgery. 64:414-420
Background. Cyclosporin A is known to alter endothelium-dependent responses to different agonists. Few data are available concerning the effect of cyclosporin A on the pulmonary vascular bed. Methods. The endothelium-dependent responses to acetylchol
Publikováno v:
The Annals of Thoracic Surgery. 57:956-959
It was previously shown that topical application of heparin produces enhanced bleeding from small vessels and capillaries. Adenosine triphosphate at low concentrations is able to dislodge heparin bound to a receptor, counteracting its antihemostatic
Publikováno v:
The Annals of Thoracic Surgery. 52:971-978
Isolated canine hearts were preserved at 4 degrees C with multi-dose cardioplegic solution every hour for 6 hours. Reperfusion was observed for 2 hours under cross-circulation without cardiotonic drugs. The aprotinin group (n = 8), which received car
Publikováno v:
The Annals of thoracic surgery. 87(2)
We present two cases of catecholamine-refractory and vasopressin-refractory vasoplegic syndrome associated with intraoperative anaphylaxis during cardiac surgery. One case was related to the administration of protamine and the other case to the admin
Autor:
Ernst Wolner, Christoph Holzinger, S Huber, Thomas Binder, Faragh Coraim, Josef Spatt, Severin P. Schwarzacher, Heinz Weber, W. Zwölfer, F Peschl, Rainald Seitelberger
Publikováno v:
The Annals of Thoracic Surgery. 49:61-68
We performed a randomized study on patients undergoing elective coronary bypass grafting to examine whether postoperative infusion of nifedipine (n = 25) could reduce the incidence of isolated transient myocardial ischemia, myocardial infarction, or