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Publikováno v:
The American journal of physiology. 277(6)
We have previously shown that chronic estrogen therapy improves endothelium-dependent vasodilation in the resistance vessels of biological males. Whether this is nitric oxide (NO) mediated and whether estrogen improves metabolic vasodilation is unkno
Autor:
Lilly Quan, Christopher G. Sobey
Publikováno v:
The American journal of physiology. 277(5)
Subarachnoid hemorrhage (SAH) is associated with impaired nitric oxide (NO)-mediated cerebral vasodilatation. We tested the hypothesis that SAH causes alterations in the production of, hydrolysis of, or responsiveness to cGMP in the rat basilar arter
Publikováno v:
The American journal of physiology. 277(4)
In the rat intestinal and cerebral microvasculatures, acute d-glucose hyperglycemia suppresses endothelium-dependent dilation to ACh without affecting endothelium-independent dilation to nitroprusside. This study determined whether acute hyperglycemi
Autor:
Roberto J. Groszmann, Vijay Shah, Greg Cadelina, William C. Sessa, Guillermo García-Cardeña, Reiner Wiest
Publikováno v:
The American journal of physiology. 277(2)
The molecular chaperone, heat shock protein 90 (Hsp90), acts as an intermediate in the signaling cascades leading to activation of endothelial nitric oxide synthase (eNOS). In this study, we examine the participation of this pathway in nitric oxide (
Publikováno v:
The American journal of physiology. 277(1)
Among chicken strains, broilers are prone to pulmonary hypertension, whereas Leghorns are not. Relaxations to endothelium-dependent (ACh, A23187) and endothelium-independent [sodium nitroprusside (SNP), papaverine (PPV)] vasodilators were compared in
Autor:
Georg Rainer, Oliver Findl, Barbara Kiss, Susanne Dallinger, Leopold Schmetterer, Hans-Georg Eichler
Publikováno v:
The American journal of physiology. 276(6)
Acetazolamide, a carbonic anhydrase inhibitor, is used orally in the treatment of primary and secondary open-angle glaucoma and induces ocular and cerebral vasodilation. Several in vitro studies have shown that carbonic anhydrase pharmacology and the
Publikováno v:
The American journal of physiology. 276(5)
We studied in anesthetized rats whether aminopeptidase P (AMP) may be involved in bradykinin (BK) metabolism and responses. For this we inhibited AMP with the specific inhibitor apstatin (Aps). Studies were done with Aps alone or together with the an
Publikováno v:
The American journal of physiology. 276(2)
Na+-K+-ATPase plays a major role in regulating membrane potential and vascular tone. We analyzed the modulation by norepinephrine (NE), endothelin-1 (ET-1), and phorbol 12-myristate 13-acetate (PMA) of Na+-K+-ATPase-induced cytoplasmic free Ca2+conce
Autor:
Andra S. Stevenson, Thomas Kleppisch, Adrian D. Bonev, Valerie A. Porter, Mark T. Nelson, Harm J. Knot, W. J. Lederer, Thomas J. Heppner
Publikováno v:
The American journal of physiology. 274(5)
Forskolin, which elevates cAMP levels, and sodium nitroprusside (SNP) and nicorandil, which elevate cGMP levels, increased, by two- to threefold, the frequency of subcellular Ca2+release (“Ca2+sparks”) through ryanodine-sensitive Ca2+release (RyR
Autor:
William M. Armstead
Publikováno v:
The American journal of physiology. 274(5)
ATP-dependent K+(KATP) channel function is impaired after fluid percussion brain injury (FPI). Additionally, the nitric oxide (NO) releaser sodium nitroprusside and a cGMP analog elicit pial dilation via KATP channel activation, whereas opioids such