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Autor:
Lilin Zhong, Carlota Sumbilla, Iain K. Farrance, Hailun Ma, Giuseppe Inesi, Marco Cavagna, David A. Lewis
Publikováno v:
The American journal of physiology. 277(6)
Cultured COS-1 cells, as well as chicken embryonic and neonatal rat cardiac myocytes, were infected with recombinant adenovirus vectors to define limiting factors in the expression and Ca2+transport function of recombinant sarcoplasmic-endoplasmic re
Autor:
David A. Wink, Stefano Vicini, Muyiwa Gbadegesin, Sandra J. Hewett, Carol A. Colton, Ryszard M. Pluta, Michael Graham Espey
Publikováno v:
The American journal of physiology. 277(4)
Nitric oxide (NO) released from a new chemical class of donors enhances N-methyl-d-aspartate (NMDA) channel activity. Using whole cell and single-channel patch-clamp techniques, we have shown that ( Z)-1-[ N-(3-ammoniopropyl)- N-( n-propyl)amino]-NO
Publikováno v:
The American journal of physiology. 277(4)
Sodium 4-phenylbutyrate (PBA), a short-chain fatty acid, has been approved to treat patients with urea cycle enzyme deficiencies and is being evaluated in the management of sickle cell disease, thalassemia, cancer, and cystic fibrosis (CF). Because r
Publikováno v:
The American journal of physiology. 276(6)
The CLCA family of Ca2+-activated Cl−channels has recently been discovered, with an increasing number of closely related members isolated from different species. Here we report the cloning of the second human homolog, hCLCA2, from a human lung cDNA
Autor:
Christian Weber, Philipp von Hundelshausen, H. W. Löms Ziegler-Heitbrock, Marion Frankenberger, Georg Draude
Publikováno v:
The American journal of physiology. 276(4)
The CD14+/CD16+subset of human blood monocytes, which expresses low levels of the lipopolysaccharide receptor CD14 and high levels of the Fc receptor CD16 and exhibits features of mature tissue macrophages, is expanded in certain inflammatory conditi
Autor:
Robert J. Bridges, H. Skipper Smith, Christopher C. Widnell, Neil A. Bradbury, John A. Clark, Simon C. Watkins
Publikováno v:
The American journal of physiology. 276(4)
Mutations in the gene encoding the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) chloride channel give rise to the most common lethal genetic disease of Caucasian populations, CF. Although the function of CFTR is primarily related t
Publikováno v:
The American journal of physiology. 276(1)
Pancreatic dysfunction in patients with cystic fibrosis (CF) is felt to result primarily from impairment of ductal[Formula: see text] secretion. We provide molecular evidence for the expression of NBC-1, an electrogenic Na+-[Formula: see text]cotrans
Autor:
Daniela Sciaky, Edward C. Kim, Yingting Zhu, Valerie Andersen, Terry J. Smith, Heather Meekins, H. James Cao, Peter Lance
Publikováno v:
Scopus-Elsevier
We investigated prostanoid biogenesis in human colonic fibroblasts (CCD-18Co and 5 primary fibroblast cultures) and epithelial cell lines (NCM460, T84, HT-29, and LS 174T) and the effect of PGE2on fibroblast morphology. Cytokine-stimulated PGE2produc
Publikováno v:
The American journal of physiology. 275(3)
The mechanism by which Bcl-2 inhibits cell death is unknown. It has been suggested that Bcl-2 functions as an antioxidant. Because Bcl-2 is localized mainly to the membranes of the endoplasmic reticulum (ER) and the mitochondria, which represent the
Autor:
George I. Gorodeski
Publikováno v:
The American journal of physiology. 275(3)
Estrogens increase secretion of cervical mucus in females. The objective of this research was to study the mechanisms of estrogen action. The experimental models were human CaSki (endocervical) and hECE (ectocervical) epithelial cells cultured on fil