Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Kazuo Achiwa"'
Publikováno v:
Tetrahedron Letters. 41:499-502
A biocatalytic dediastereomerization method, i.e. reactions allowing the transformation of two diastereomers into one diastereomer in quantitative yield, has been developed.
Autor:
Kazuo Achiwa, Masumi Takemoto
Publikováno v:
Tetrahedron Letters. 40:6595-6598
A new method has been developed for the synthesis of styrenes through the decarboxylation of trans-cinnamic acids by plant cell cultures at room temperature. 4-Hydroxy-3-methoxystyrene (2a), 3-nitrostyrene (2d) and furan (2e) were synthesized quantit
Inversion of enantioselectivity in hydrolysis of 1,4-dihydropyridines by point mutation of lipase PS
Publikováno v:
Tetrahedron Letters. 36:1063-1066
Mutant of lipase PS replaced three amino acids by site-specific mutagenesis first showed the inversion of enantioselectivity and the solvent effect in hydrolysis of 1,4-dihydropyridines.
Publikováno v:
Tetrahedron Letters. 34:5915-5918
The first protease-catalyzed enantioselective transesterification of 1,4-dihydropyridine-3,5-dicarboxylates in an aqueous solution was developed with high optical purity. Carbamoylmethyl ester group was enantioselectively transesterificated with (S)-
Publikováno v:
Tetrahedron Letters. 34:3441-3444
The first enantioselective protease-catalyzed hydrolyses of 1,4-dihydropyridine-3,5-dicarboxyric diesters were developed. The monoesters obtained had high optical purity and were useful chiral building blocks which could easily lead to optically acti
Publikováno v:
Tetrahedron Letters. 33:7157-7160
Two enantiomers of 1,4-dihydropyridine compounds have been obtained with high enantiomeric purity by lipase-catalyzed hydrolysis in organic solvent saturated with water. Enantioselectivity of this reaction is dependent on the solvent used.
Autor:
Masakazu Murata, Kazuo Achiwa
Publikováno v:
Tetrahedron Letters. 32:6763-6766
Publikováno v:
Tetrahedron Letters. 32:5805-5808
The first practical syntheses of chiral 4-aryl-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylates, which are attractive compounds as new calcium antagonists, were realized by lipase-catalyzed enantioselective hydrolysis of the acyloxymethyl esters.
Publikováno v:
Tetrahedron Letters. 31:261-264
An efficient total synthesis of (−)-deoxypodophyllotoxin has been achieved by employing the asymmetric hydrogenation of α-piperonylidenesuccinic acid half ester with a rhodium(I) complex of (S,S)-MOD-DIOP as a key step.
Publikováno v:
Tetrahedron Letters. 17:2557-2560