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Autor:
Ben Markman, Manuel Hidalgo, D. Harris, Michael B. Jameson, Dusan Kotasek, Michael Millward, Robert Joseph Stagg, Mark J. McKeage, Ann M. Kapoun, Lu Xu, Brett G.M. Hughes
Publikováno v:
Targeted oncology. 13(1)
Delta-like ligand 4-Notch (DLL4-Notch) signaling contributes to the maintenance of chemotherapy-resistant cancer stem cells and tumor vasculature. This phase IB trial of demcizumab, an IgG2 humanized monoclonal antibody directed against DLL4, was und