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Autor:
Kyeong-A Kim, Seung-Hoon Baek, G K Rajanikant, Donggeun Shin, Ok-Nam Bae, Jeong-Hyeon Kim, Arshad Majid, Young-Jun Shin
Publikováno v:
Stroke. 49:1571-1579
The global burden of neurological diseases including stroke has significantly increased,1 and an urgent need exists to develop new treatment strategies. Impairment of autophagic regulation has been observed in diseases including neurodegenerative dis
Autor:
Michael Chopp, Jieli Chen
Publikováno v:
Stroke. 49:1083-1090
Nearly, all cells generate and eject vesicles, and these vesicles constitute major vehicles for intercellular communication. Exosomes, as nanosized vesicles (≈30–100 nm in diameter1), target cell function by delivering proteins, lipids, and nucle
Autor:
Ken Arai
Publikováno v:
Stroke. 50
Advancing age is major risk factor for development of many central nervous system diseases including stroke. Three recent studies provide novel mechanisms for how aging causes brain dysfunction with implications for potential targets for stroke thera
Publikováno v:
Stroke. 41:2056-2063
Background and Purpose— Enhanced vascular permeability attributable to disruption of blood–brain barrier results in the development of cerebral edema after stroke. Using an in vitro model of the brain barrier composed of human brain microvascular
Autor:
Greta I. Berg, Gregory J. del Zoppo, Richard Milner, Xiaoyun Wang, James A. Koziol, Stephanie Hung, Takuma Mabuchi
Publikováno v:
Stroke. 38:646-651
Local environmental conditions contribute to the activation state of cells. Extracellular matrix glycoproteins participate in cell-cell boundaries within the microvascular and extravascular tissues of the central nervous system and provide a scaffold
Autor:
Sun-Ryung Lee, Eng H. Lo
Publikováno v:
Stroke. 34:2704-2709
Background and Purpose— The emerging concept of the neurovascular unit in stroke reemphasizes the need to focus on endothelial responses in brain. In this study we examined the role of mitogen-activated protein (MAP) kinase signaling in the regulat
Autor:
Rachel C. Brown, Thomas P. Davis
Publikováno v:
Stroke. 33:1706-1711
Background — This review deals with the role of calcium in endothelial cell junctions of the blood-brain barrier (BBB). Calcium is critical for adherens junction function, but it appears that calcium is also important in regulating tight junction f
Autor:
Pierluigi Nicotera, Daniele Bano
Publikováno v:
Stroke. 38:674-676
Although Ca 2+ signals are necessary for cell communication and survival, abnormal cellular Ca 2+ load can trigger different cell death programs. Ca 2+ mediates cell death by activating proteases (ie, calpains), by reinforcing signals leading to casp
Publikováno v:
Stroke. 29:229-234
Background —Cerebral blood flow is tightly coupled to neuronal metabolic activity, a phenomenon referred to as functional hyperemia. The mechanisms underlying functional hyperemia in the brain have been extensively studied, but the link between neu
Autor:
Julie A. Saugstad
Publikováno v:
Stroke. 44
MicroRNAs (miRNAs) are a recently discovered family of small, genome-encoded endogenous RNAs that are transcribed but are not translated into proteins. Early studies in Ceanorhabditis elegans revealed that an endogenous small RNA (lin-4) regulated tr