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Autor:
Ken Arai
Publikováno v:
Stroke. 50
Advancing age is major risk factor for development of many central nervous system diseases including stroke. Three recent studies provide novel mechanisms for how aging causes brain dysfunction with implications for potential targets for stroke thera
Publikováno v:
Stroke. 41:2056-2063
Background and Purpose— Enhanced vascular permeability attributable to disruption of blood–brain barrier results in the development of cerebral edema after stroke. Using an in vitro model of the brain barrier composed of human brain microvascular
Autor:
Greta I. Berg, Gregory J. del Zoppo, Richard Milner, Xiaoyun Wang, James A. Koziol, Stephanie Hung, Takuma Mabuchi
Publikováno v:
Stroke. 38:646-651
Local environmental conditions contribute to the activation state of cells. Extracellular matrix glycoproteins participate in cell-cell boundaries within the microvascular and extravascular tissues of the central nervous system and provide a scaffold
Autor:
James A. Clemens, Edda F. Roberts, John D. Sharp, Edward M. Johnstone, Ruth M. Kramer, Diane T. Stephenson, E B Smalstig, Sheila P. Little
Publikováno v:
Stroke. 27:527-535
Background and Purpose Phospholipid breakdown has been reported to be an early event in the brain after global cerebral ischemia. Our earlier observations showing the localization of cytosolic phospholipase A 2 (cPLA 2 ) to astrocytes in aged human b