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Autor:
Michael Chopp, Jieli Chen
Publikováno v:
Stroke. 49:1083-1090
Nearly, all cells generate and eject vesicles, and these vesicles constitute major vehicles for intercellular communication. Exosomes, as nanosized vesicles (≈30–100 nm in diameter1), target cell function by delivering proteins, lipids, and nucle
Autor:
Ken Arai
Publikováno v:
Stroke. 50
Advancing age is major risk factor for development of many central nervous system diseases including stroke. Three recent studies provide novel mechanisms for how aging causes brain dysfunction with implications for potential targets for stroke thera
Autor:
Julie A. Saugstad
Publikováno v:
Stroke. 44
MicroRNAs (miRNAs) are a recently discovered family of small, genome-encoded endogenous RNAs that are transcribed but are not translated into proteins. Early studies in Ceanorhabditis elegans revealed that an endogenous small RNA (lin-4) regulated tr
Autor:
Mark Fisher
Publikováno v:
Stroke. 40
Brain pericytes are intimately associated with capillary endothelial cells, separated only by basement membrane. Pericyte research has been hampered by absence of pericyte-specific immunochemical markers. The vast array of pericyte functions include