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Autor:
Vuong Cat Khanh, Hiromi Hamada, Motoo Osaka, Yun Hsuan Chang, Toshiharu Yamashita, Mana Obata-Yasuoka, Osamu Ohneda, Ngo Nhat Hoang, Mizuho Fukushige, Yuji Hiramatsu
Publikováno v:
Stem Cells and Development
Cytokine storm is recognized as one of the factors contributing to organ failures and mortality in patients with COVID-19. Due to chronic inflammation, COVID-19 patients with diabetes mellitus (DM) or renal disease (RD) have more severe symptoms and
Autor:
Joshua M. Spin, Dong Wang, Hermann Reichenspurner, Tobias Deuse, Sonja Schrepfer, Francis G. Blankenberg, J. Guihaire, Elie Fadel
Publikováno v:
Stem cells and development. 30(10)
Inflammation plays a major role in the pathogenesis of pulmonary hypertension (PH). We sought to investigate the effects of a cell-based immunomodulation in a dysimmune model of PH. PH was induced in athymic nude rats using semaxinib (Su group
Publikováno v:
Stem cells and development. 30(9)
Corona virus disease 2019 (COVID-19) refers to a type of pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Sixty million confirmed cases have been reported worldwide until November 29, 2020. Unfortunately, th
Autor:
Nicola Hellen, Sian E. Harding, Gail Whiting, Karine Vauchez, Carolina P. Ricardo, Jun X. Wheeler
Publikováno v:
Stem Cells and Development. 28:565-578
Human induced pluripotent stem cell-derived cardiomyocytes hold great promise for regenerative medicine and in vitro screening. Despite displaying key cardiomyocyte phenotypic characteristics, they more closely resemble foetal/neonatal cardiomyocytes
Publikováno v:
Stem Cells and Development
The lung is the most vulnerable target for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, and respiratory failure causing acute respiratory distress syndrome is its foremost outcome. However, the current primary in vitro
Publikováno v:
Stem Cells and Development. 27:35-43
Human endometrial mesenchymal stem cells (eMSCs) are a well-characterized adult stem cell type with potential for use in regenerative medicine or cell therapy. As a proof of principle, we demonstrated that eMSCs promoted wound healing by reducing the
Autor:
Ahmad Abu-Khader, Gavin Boisjoli, Nicolas Pineault, Owen Hovey, Roya Pasha, Emily Doxtator, Matthew Michalicka, Suria Jahan
Publikováno v:
Stem Cells and Development. 26:1735-1748
Coculture of hematopoietic stem cells (HSC) with primary stromal cells from HSC niches supports the maintenance and expansion of HSC and progenitors ex vivo. However, a major drawback is the availability of primary human samples for research and clin
Publikováno v:
Stem Cells and Development. 26:1781-1803
Ovarian cancer is most lethal among gynecological cancers with often fatal consequences due to lack of effective biomarkers and relapse, which propels ovarian cancer research into unique directions to establish solid targeted therapeutics. “Ovarian
Publikováno v:
Stem Cells and Development. 26:1477-1489
Sepsis is a complex process, including a first wave of damage partially due to the body's response to pathogens, followed by a phase of immune cell dysfunction. The efficacy of a pharmacological approach facing a rapidly evolving system implies a per
Autor:
Cesare Perotti, Marina Morigi, Niccolò Bianchi, Claudia Del Fante, Barbara Imberti, Anna Pezzotta, Manuela Monti, Carlo Alberto Redi
Publikováno v:
Stem Cells and Development. 26:1258-1269
Very small embryonic-like cells (VSELs) are a population of very rare pluripotent stem cells isolated in adult murine bone marrow and many other tissues and organs, including umbilical cord blood (UCB). VSEL existence is still not universally accepte