Zobrazeno 91 - 100
of 505
pro vyhledávání: ''
Autor:
N IjzermansJan, U EngelaAnja, de JongeJeroen, WeimarWillem, VerstegenMonique, C BaanCarla, Roemeling-van RhijnMarieke, MerinoAna, G H BetjesMichiel, S KorevaarSander, J HoogduijnMartin, FranquesaMarcella, J W van der LaanLuc
Publikováno v:
Stem Cells and Development, 23(19), 2328-2335. Mary Ann Liebert Inc.
Mesenchymal stem cells (MSC) are present in the bone marrow, from where they are thought to migrate through the blood stream to the sites of injury. However, virtually all tissues contain resident MSC that may contribute to local regenerative and imm
Publikováno v:
Stem cells and development. 26(7)
Umbilical cord blood (UCB) transplantation can provide a successful therapeutic option for patients that have no suitable related donor. UCB transplantation is often limited by the relatively small hematopoietic stem cell (HSC) numbers in UCB especia
Autor:
Chi Chiu Wang, Wayne Yuk-Wai Lee, Tianyi Wu, Bin Wang, Biao Huang, Jinfang Zhang, Xiaohua Jiang, Gang Li
Publikováno v:
Stem cells and development. 25(22)
Autologous mesenchymal stem cells (MSC) are widely used cell source for cell-based tissue repair and regeneration, but replicative senescence and the associated loss of cellular activity during in vitro expansion limit their therapeutic potential. Ho
Autor:
Ashley I. Beyer, Marcus O. Muench
Publikováno v:
Stem cells and development. 26(2)
Immunodeficient mice play a critical role in hematology research as in vivo models of hematopoiesis and immunology. Multiple strains have been developed, but hematopoietic stem cell engraftment and immune reconstitution have not been methodically com
Autor:
Giuliana Castello Coatti, Miguel Mitne-Neto, M. Valadares, Mayra Pelatti, A. Assoni, Melinda Beccari, Mayana Zatz, Valdemir Melechco Carvalho, J. Gomes
Publikováno v:
Stem cells and development. 26(3)
Duchenne muscular dystrophy (DMD) is a lethal X-linked disorder caused by null mutations in the dystrophin gene. Although the primary defect is the deficiency of muscle dystrophin, secondary events, including chronic inflammation, fibrosis, and muscl
Autor:
J LinLevina, JiSunjong, RezekValerie, J SmithDrake, T PhamAlexander, RuizMarlene, A ZackJerome, AnDong Sung, YangLili, MemarzadehSanaz, WangXi, LamJennifer, B KohnDonald, G KitchenScott, M JanzenDeanna, ShimizuSaki, MoonHeesung, LiuSiyuan
Publikováno v:
Stem cells and development, vol 25, iss 24
The humanized BLT (bone marrow-liver-thymus) mouse model harbors a nearly complete human immune system, therefore providing a powerful tool to study human immunology and immunotherapy. However, its application is greatly limited by the restricted sup
Autor:
Hee-Jun Na, Yee Sook Cho, Bin Yoo, Young-Dae Kim, Mi-Ok Lee, Mi-Young Son, Jae-Suk Chang, Binna Seol
Publikováno v:
Stem cells and development. 26(2)
Behcet's disease (BD) is a chronic inflammatory and multisystemic autoimmune disease of unknown etiology. Due to the lack of a specific test for BD, its diagnosis is very difficult and therapeutic options are limited. Induced pluripotent stem cell (i
Autor:
Li Wang, Zhenyang Gu, Xiaoli Zhao, Nan Yang, Feiyan Wang, Ailing Deng, Shasha Zhao, Lan Luo, Huaping Wei, Lixun Guan, Zhe Gao, Yonghui Li, Lili Wang, Daihong Liu, Chunji Gao
Publikováno v:
Stem cells and development. 25(24)
Mesenchymal stromal cells (MSCs) are attractive agents for the prophylaxis of acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, safety concerns remain about their clinical applicati
Autor:
Hal E. Broxmeyer, Sherif S. Farag
Publikováno v:
Stem Cells and Development. 22:103-110
Cord blood (CB) has been used since 1988 as a source of hematopoietic stem cells (HSCs) and progenitor cells for hematopoietic cell transplantation (HCT) to treat patients with malignant and nonmalignant disorders. CB has both advantages and disadvan
Autor:
Susanne Herndlhofer, Eva Jaeger, Peter Valent, Ingrid Simonitsch-Klupp, Irene Steiner, Gregor Hoermann, Elisa Einwallner, Elisabeth Pernicka, Ilse Schwarzinger, Martin Bilban, Christian Sillaber, Gerlinde Mitterbauer-Hohendanner
Publikováno v:
Stem Cells and Development. 22:3043-3051
In vitro endogenous erythroid colony (EEC) formation is a common finding in BCR-ABL-negative myeloproliferative neoplasms. The aim of the present study was to determine the prevalence and the clinical significance of EEC growth in chronic myeloid leu