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Publikováno v:
Stem Cells and Development. 31:269-277
Human pluripotent stem cells (hPSCs), including human embryonic stem cells and human induced pluripotent stem cells (hiPSCs), provide promising sources for regenerative therapy, disease modeling, and drug screening. Relevant efforts have been investe
Autor:
Paige A. Winkler, Ratnesh K. Singh, Francois Binette, Simon M. Petersen-Jones, Igor O. Nasonkin
Publikováno v:
Stem Cells Dev
Progressive vision loss, caused by retinal degenerative (RD) diseases such as age-related macular degeneration, retinitis pigmentosa, and Leber congenital amaurosis, severely impacts quality of life and affects millions of people. Finding efficient t
Autor:
Wenping Luo, Shuang Li, Liwen Zheng, Zhuohui Yang, Xia Huang, Juhong Lin, Qianyu Cheng, Pengfei Zhou, Hongmei Zhang, Qiuman Chen, Yingying Tang, Tong-Chuan He, Yuxin Zhang, Feilong Wang
Publikováno v:
Stem Cells and Development. 29:1059-1072
Dental mesenchymal stem cells (MSCs) are recognized as a critical factor in repair of defective craniofacial bone owing to the multiple differentiation potential, the ability to regenerate distinct tissues, and the advantage that they can be easily o
Publikováno v:
Stem cells and development. 29(16)
Exosomes derived from mesenchymal stromal cells (MSCs) have emerged as novel drug and gene delivery tools. Current study aimed to elucidate the potential therapeutic role of human placental MSC (hPLMSC)-derived exosomes carrying AntagomiR-4450 (EXO-A
Autor:
Akiko Ogawa, Kazunari Higa, Hideyuki Miyashita, Kazuya Yamashita, Shigeto Shimmura, Shin Hatou, Emi Inagaki, Kazuo Tsubota
Publikováno v:
Stem Cells and Development. 27:1097-1108
Corneal blindness is the third leading cause of blindness in the world, and one of the main etiologies is dysfunction of the corneal endothelium. Current treatment of corneal endothelial disease is allogenic corneal transplantation, which is limited
Publikováno v:
Stem Cells and Development. 25:1733-1741
A fundamental understanding of prostate development and tissue homeostasis has the high potential to reveal mechanisms for prostate disease initiation and identify novel therapeutic approaches for disease prevention and treatment. Our current underst
Autor:
Carmine Cozzolino, Carlo Ruosi, Francesca Querques, Eleonora Leggiero, Luca Cozzuto, Barbara Lombardo, Anna D'Agostino, Lucio Pastore
Publikováno v:
Stem cells and development. 28(6)
Osteogenic differentiation is a complex and still poorly understood biological process regulated by intrinsic cellular signals and extrinsic microenvironmental cues. Following appropriate stimuli, mesenchymal stem cells (MSCs) differentiate into oste
Autor:
D.A.F. Villagómez, Courtney R. Brooks, Dean H. Betts, Jonathan H. Teichroeb, Cheryle A. Séguin, Ian C. Tobias, David A. Hess
Publikováno v:
Bone and Joint Institute
© 2016 Mary Ann Liebert, Inc. Naïve and primed pluripotent stem cells (PSCs) reflect discrete pluripotent states that approximate the inner cell mass or the progressively lineage-restricted perigastrulation epiblast, respectively. Cells that occupy
Publikováno v:
Stem cells and development. 27(4)
Dynamic suspension culture of human pluripotent stem cells (hPSCs) in stirred bioreactors provides a valuable scalable culture platform for integrated differentiation toward different lineages for potential research and therapeutic applications. Howe
Publikováno v:
Stem Cells and Development. 24:384-392
Human embryonic stem (HUES) cells are derived from early individual embryos with unique genetic printing. However, how their epigenetic status might affect their potential to differentiate toward specific lineages remains a puzzling question. Using c