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of 55
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Autor:
Ivo Lambrichts, Tom Struys, Pascal Gervois, Wendy Martens, Annelies Bronckaers, Constantinus Politis, Bert Brône, Jessica Ratajczak, Petra Hilkens
Publikováno v:
Stem Cells and Development. 24:296-311
Cell-based therapies are emerging as an alternative treatment option to promote functional recovery in patients suffering from neurological disorders, which are the major cause of death and permanent disability. The present study aimed to differentia
Autor:
Megan Ealy, Kazuo Oshima, Giovanni H. Diaz, Lydia-Marie Joubert, Robert Durruthy-Durruthy, Marjan Nasr, Joerg Waldhaus, Stefan Heller, Mohammad Ronaghi
Publikováno v:
Stem Cells and Development. 23:1275-1284
In mammals, the permanence of many forms of hearing loss is the result of the inner ear's inability to replace lost sensory hair cells. Here, we apply a differentiation strategy to guide human embryonic stem cells (hESCs) into cells of the otic linea
Publikováno v:
Stem cells and development. 26(7)
Umbilical cord blood (UCB) transplantation can provide a successful therapeutic option for patients that have no suitable related donor. UCB transplantation is often limited by the relatively small hematopoietic stem cell (HSC) numbers in UCB especia
Autor:
Xiaoyan Zhang, Xiaoni Li, Hongxi Zhao, Jichun Tan, Jinhua Wen, Ruopeng Feng, Dapeng Tai, Guangyu An, Yang Li
Publikováno v:
Stem Cells and Development. 22:1147-1158
The technology to reprogram human somatic cells back to pluripotency allows the production of patient-specific induced pluripotent stem cells (iPSCs) and holds a great promise for regenerative medicine. Choosing the most suitable cell type for induct
Autor:
Masakatsu Sone, Hiroshi Arai, Kazumasa Nakao, Eri Kondo, Masako Miura, Kazuwa Nakao, Naotetsu Kanamoto, Akihiro Yasoda, Kazuhisa Bessho, Toshihito Fujii, Daisuke Taura, Noriaki Koyama
Publikováno v:
Stem Cells and Development. 22:102-113
Human induced pluripotent stem cells (hiPSCs) exhibit pluripotency, proliferation capability, and gene expression similar to those of human embryonic stem cells (hESCs). hESCs readily form cartilaginous tissues in teratomas in vivo; despite extensive
Autor:
Leonardo Sganga, Marcela F. Bolontrade, Mariana Garcia, Guillermo Mazzolini, Eduardo Piaggio, Diego L. Viale, Miguel A. Sorrentino, Osvaldo L. Podhajcer, Gustavo Sevlever, Anibal Robinson
Publikováno v:
Stem Cells and Development. 21:2689-2702
The homing properties of mesenchymal stromal c´ells (MSCs) toward tumors turn them into attractive tools for combining cell and gene therapy. The aim of this study was to select in a feasible way a human bone marrow-derived MSC subpopulation that mi
Publikováno v:
Stem Cells and Development. 21:2364-2373
High expectations surround the area of stem cells therapeutics. However, the cells' source-adult or embryonic-and the cells' origin-patient-derived autologous or healthy donor genetically unrelated-remain subjects of debate. Autologous origins have t
Autor:
V Legorreta-HaquetMaría, R Fajardo-OrduñaGuadalupe, J MontesinosJuan, E Castro-ManrrezaMarta, K Chávez-RuedaAdriana, Piña-SánchezPatricia, Hernández-EstévezErika, MayaniHector, Flores-FigueroaEugenia, Arriaga-PizanoLourdes, E Castell-RodríguezAndrés, Flores-GuzmánPatricia, Santiago-OsorioEdelmiro
Publikováno v:
Stem cells and development. 25(17)
The differentiation capacity, hematopoietic support, and immunomodulatory properties of human bone marrow mesenchymal stromal cells (BM-MSCs) make them attractive therapeutic agents for a wide range of diseases. Clinical scale cultures (CSCs) have be
Publikováno v:
Stem cells and development. 25(9)
Remyelination is the goal of potential cell transplantation therapies for demyelinating diseases and other central nervous system injuries. Transplantation of oligodendrocyte precursor cells (OPCs) can result in remyelination in the central nervous s
Publikováno v:
Stem cells and development. 21(1):19-29
Mesenchymal stromal cells (MSC) represent a type of multipotent cells that can be isolated from several human tissues and that can be expanded ex vivo for clinical application. The regenerative and immune modulatory capacities of MSC have raised hope