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Publikováno v:
Stem cells (Dayton, Ohio). 36(9)
The objective of this Review is to describe the safety and efficacy of adipose stem/stromal cells (ASC) and stromal vascular fraction (SVF) in treating common diseases and the next steps in research that must occur prior to clinical use. Pubmed, Ovid
Autor:
Tatiana E. Salazar, Ruchi J. Vyas, Sugata Hazra, Patricia Parsons-Wingerter, Yaqian Duan, Jude Al-Sabah, Troy A. Markel, Judith Quigley, Leni Moldovan, Eleni Beli, Michael E. Boulton, Dongni Feng, Sergio Li Calzi, Maria B. Grant, Alexander G. Obukhov, Gavin Y. Oudit, Matthew C. Murray, Kakarla V. Chalam, Marya Meroueh, Rehae C. Miller, Thao Trinh
Publikováno v:
Stem cells (Dayton, Ohio). 36(9)
Angiotensin-converting enzyme 2 (ACE2) is the primary enzyme of the vasoprotective axis of the renin angiotensin system (RAS). We tested the hypothesis that loss of ACE2 would exacerbate diabetic retinopathy by promoting bone marrow dysfunction. ACE2
Autor:
Dmitri O. Traktuev, Phillip L. Johnson, Stephanie D. Fitz, Marcelo Febo, Mervin C. Yoder, Todd O. McKinley, Jared A. Smith, Robyn K. Fuchs, Matthew R. Richardson, Jamie Case, Lung-Ji Chang, Maria B. Grant, Jeffrey S. Thinschmidt, Emily K. Sims, Yaqian Duan, Huisheng Xie, Xinzhong Dong, Bruce McDavitt, Keith L. March, Youngsook Kim, Alicia L. Bertone, Minsu Kim, Leni Moldovan, Keith G. Avin, Luis M. Colon-Perez, Eleni Beli, John George, Zhanguo Gao, Matthew S. Ripsch, Susan P. McGorray, Sergio Li Calzi, Julie A. Mund, Stuart J. Warden, Fletcher A. White, Song Lai, Xiaolin Deng, Jingfeng Ma, Michael E. Boulton, Vaishnavi Jadhav, Anantha Shekhar, Mikhail G. Kolonin, Tatiana Salazar, Ashay D. Bhatwadekar, Yuanqing Yan
Publikováno v:
Stem cells (Dayton, Ohio). 35(5)
Electroacupuncture (EA) performed in rats and humans using limb acupuncture sites, LI-4 and LI-11, and GV-14 and GV-20 (humans) and Bai-hui (rats) increased functional connectivity between the anterior hypothalamus and the amygdala and mobilized mese
Autor:
Masahito Matsumoto, Emma Jamieson, Fang-Xu Jiang, Grant Morahan, Adrian Charles, Jan E. Dickinson, Kevin Li, Michael Archer, Munish Mehta
Publikováno v:
Stem cells (Dayton, Ohio). 35(5)
Developmental stage-specific differentiation of stem or progenitor cells into safe and functional cells is of fundamental importance in regenerative medicine, including β-cell replacement. However, the differentiation of islet progenitor cells (IPCs
Autor:
Paul M. O'Connor, Cheryl L. Walker, Ayman Al-Hendy, Leyland Stone, Daniel T. Kleven, Carlos Simón, Aymara Mas, Qiwei Yang
Publikováno v:
Stem cells (Dayton, Ohio). 35(3)
Despite the high prevalence and major negative impact of uterine fibroids (UFs) on women's health, their pathogenesis remains largely unknown. While tumor-initiating cells have been previously isolated from UFs, the cell of origin for these tumors in
Autor:
Celine J. Granier, Mantu Bhaumik, Yuan Xiang Tao, Ghassan Yehia, J. Patrick Gonzalez, Natalia Shirokova, Kevin C. Lahey, Joel S. Schneider, Viktoriia Kyrychenko, Sergii Kyrychenko, Qingshi Zhao, Eric Himelman, Diego Fraidenraich
Publikováno v:
Stem cells (Dayton, Ohio). 35(3)
Duchenne muscular dystrophy (DMD) is characterized by the loss of the protein dystrophin, leading to muscle fragility, progressive weakening, and susceptibility to mechanical stress. Although dystrophin-negative mdx mouse models have classically been
Autor:
Mirella Dottori, Mark Denham, Jessie Leung, Brock James Conley, Lachlan H. Thompson, Christopher R. Bye
Publikováno v:
Stem Cells (Dayton, Ohio)
The floor plate is one of the major organizers of the developing nervous system through its secretion of sonic hedgehog (Shh). Although the floor plate is located within the neural tube, the derivation of the floor plate during development is still d
Publikováno v:
Stem cells (Dayton, Ohio). 34(11)
As known from model organisms, such as frog, fish, mouse, and chicken, the anterior–posterior patterning of the definitive endoderm (DE) into distinct domains is controlled by a variety of signaling interactions between the DE and its surrounding m
Autor:
Beibei Zhu, Philip A. Kern, Se-Hyung Park, Zun Liu, Yipeng Sui, Richard G. Lee, Changcheng Zhou, Robert N. Helsley
Publikováno v:
Stem cells (Dayton, Ohio). 34(7)
IκB kinase β (IKKβ), a central coordinator of inflammation through activation of nuclear factor-κB, has been identified as a potential therapeutic target for the treatment of obesity-associated metabolic dysfunctions. In this study, we evaluated
Autor:
Eric Lam, Yie Hou Lee, Nigel P. Dyer, Sascha Ott, Jerry Kok Yen Chan, Jonathan D. Moore, Satoru Takeda, Paul J. Brighton, Giulia Grimaldi, Joanne Muter, Gnyaneshwari Patel, Jan J. Brosens, Emma S. Lucas, Yi-Wah Chan, Keisuke Murakami, Siobhan Quenby
Publikováno v:
Stem cells (Dayton, Ohio). 34(2)
© 2015 AlphaMed Press.Menstruation drives cyclic activation of endometrial progenitor cells, tissue regeneration, and maturation of stromal cells, which differentiate into specialized decidual cells prior to and during pregnancy. Aberrant responsive