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Publikováno v:
Stem Cells (Dayton, Ohio)
Quiescence and self‐renewal of human corneal epithelial progenitor/stem cells (LEPC) are regulated by the limbal niche, presumably through close interaction with limbal (stromal) niche cells (LNC). Paired box homeotic gene 6 (Pax6), a conserved tra
Publikováno v:
Stem cells (Dayton, Ohio)
Stem cells (Dayton, Ohio), vol 38, iss 1
Stem cells (Dayton, Ohio), vol 38, iss 1
Exosomes are nanovesicles secreted by virtually all cells. Exosomes mediate the horizontal transfer of various macromolecules previously believed to be cell-autonomous in nature, including nonsecretory proteins, various classes of RNA, metabolites, a
Publikováno v:
Stem Cells (Dayton, Ohio)
We previously demonstrated that Bmi1 deficiency leads to osteoporosis phenotype by inhibiting the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells (MSCs), but it is unclear whether overexpression of Bmi1 in MSCs stim
Autor:
Ru Ik Chee, Rachel Sartaj, Victor H. Guaiquil, Jing Yang, Pengxia Wan, Mark I. Rosenblatt, Elaine Fuchs, Aihong Liu
Publikováno v:
Stem Cells (Dayton, Ohio)
The cornea requires constant epithelial renewal to maintain clarity for appropriate vision. A subset of stem cells residing at the limbus is primarily responsible for maintaining corneal epithelium homeostasis. Trauma and disease may lead to stem cel
Publikováno v:
Stem cells (Dayton, Ohio). 36(7)
To explore the effects and mechanisms of paracrine factors secreted from human adipose mesenchymal stem cell (hAdMSCs) that are activated by hypoxia on radioprotection against irradiation-induced salivary hypofunction in subjects undergoing radiother
Autor:
Mehdi Najar, Patricia Renard, Marino Caruso, Etienne Sokal, Nicki Tiffin, Jean-Baka Domelevo Entfellner, Hoda El-Kehdy, Jonathan Evraerts, Guillaume Pourcher, Thierry Arnould, Catherine Demazy, Antoine Fattaccioli, Anaïs Wanet, Mustapha Najimi
Publikováno v:
Wanet, A, Caruso, M, Domelevo Entfellner, J B, Najar, M, Fattaccioli, A, Demazy, C, Evraerts, J, El-Kehdy, H, Pourcher, G, Sokal, E, Arnould, T, Tiffin, N, Najimi, M & Renard, P 2017, ' The Transcription Factor 7-Like 2-Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Axis Connects Mitochondrial Biogenesis and Metabolic Shift with Stem Cell Commitment to Hepatic Differentiation ', Stem Cells, vol. 35, no. 10, 35(10), pp. 2184-2197 . https://doi.org/10.1002/stem.2688
Increasing evidence supports that modifications in the mitochondrial content, oxidative phosphorylation (OXPHOS) activity, and cell metabolism influence the fate of stem cells. However, the regulators involved in the crosstalk between mitochondria an
Publikováno v:
Stem cells (Dayton, Ohio). 35(5)
Adult stem cells play a critical role in the maintenance of tissue homeostasis and prevention of aging. While the regenerative potential of stem cells with low cellular turnover, such as adipose-derived stem cells (ASCs), is increasingly recognized,
Autor:
Yeon-Soo Kim, Kyung-Sun Kang, Hyung Sik Kim, Seong-Wook Lee, Hae-Young Kim, Ji Hae Lee, Shyam Kishor Sah, Tae-Yoon Kim
Publikováno v:
Stem cells (Dayton, Ohio). 35(6)
The influence of mesenchymal stem cells (MSCs) on keratinocytes in altered microenvironments is poorly understood. Here, we cocultured umbilical cord blood-derived MSCs with normal human epidermal keratinocytes to evaluate their paracrine effect in t
Autor:
Ling Gao, Xiao Liu, Ni Xu, Douglas C. Dean, Henry J. Kaplan, Fangtian Dong, Yao Chen, Wei Wang, Xiaoqin Lu, Kevin C. Dean, Yongqing Liu
Publikováno v:
Stem cells (Dayton, Ohio). 35(6)
Müller cells are the major supportive and protective glial cells in the retina with important functions in histogenesis and synaptogenesis during development, and in maintenance of mature neurons as they show to secrete various cytokines and manifes
Autor:
Kaushal Joshi, Ping Mao, Diana Nardini, Yeshavanth Kumar Banasavadi-Siddegowda, Harley I. Kornblum, Xiaokui Mo, Lionel M.L. Chow, Cenk Kig, Monique Beullens, Ichiro Nakano, Ronald R. Waclaw, Robert W. Sobol, Sung Hak Kim
Publikováno v:
Stem Cells (Dayton, Ohio)
Stem cells (Dayton, Ohio), vol 31, iss 6
Stem cells (Dayton, Ohio), vol 31, iss 6
Glioblastoma multiforme (GBM) is a life-threatening brain tumor. Accumulating evidence suggests that eradication of glioma stem-like cells (GSCs) in GBM is essential to achieve cure. The transcription factor FOXM1 has recently gained attention as a m