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Autor:
Louise E. Purton, Sharon Paton, Romana Panagopoulos, Koichi Matsuo, John D. Hayball, Andrew C.W. Zannettino, Thao Nguyen, Agnieszka Arthur, Stan Gronthos
Publikováno v:
Stem cells (Dayton, Ohio). 33(9)
The tyrosine kinase receptor, EphB4, mediates cross-talk between stromal and hematopoietic populations during bone remodeling, fracture repair and arthritis, through its interactions with the ligand, ephrin-B2. This study demonstrated that transgenic
Autor:
Ruth M. Risueño, Seok-Ho Hong, Jung Bok Lee, Mickie Bhatia, Eleftherios Sachlos, Jong-Hee Lee, Eva Szabo
Publikováno v:
Stem cells (Dayton, Ohio). 30(2)
Hematopoietic stem cells (HSCs) can regenerate the entire hematopoietic system in vivo, providing the most relevant criteria to measure candidate HSCs derived from human embryonic stem cell (hESC) or induced pluripotent stem cell (hiPSC) sources. Her
Publikováno v:
Stem cells (Dayton, Ohio). 25(9)
We have utilized a serum- and stromal cell-free “spin embryoid body (EB)” differentiation system to investigate the roles of four growth factors, bone morphogenetic protein 4 (BMP4), vascular endothelial growth factor (VEGF), stem cell factor (SC
Publikováno v:
Stem cells (Dayton, Ohio). 25(6)
The role of thrombopoietin (TPO) in adult hematopoiesis is well-established. A recent report suggests that TPO and vascular endothelial growth factor (VEGF) play a role in promoting formation of early erythropoietic progenitors in a nonhuman primate
Autor:
Seishi Ogawa, Takahiro Suzuki, Shiro Kozuma, Yasuhisa Yokoyama, Mineo Kurokawa, Keiki Kumano, Mitsuo Nishikawa, Tatsutoshi Nakahata, Shigeru Chiba, Seiji Sakano, Minoko Takanashi, Tsuyoshi Takato
Publikováno v:
Stem cells (Dayton, Ohio). 24(11)
[Background and purposes] Ex vivo expansion of hematopoietic stem cells (HSCs) has been explored in the fields of stem cell biology, gene therapy and clinical transplantation. The use of Notch ligands or soluble IL-6 receptor combined with IL-6 has b
Publikováno v:
Stem cells (Dayton, Ohio). 24(9)
Supplementation of mesenchymal stem cells (MSCs) during hematopoietic stem cell (HSC) transplantation alleviates complications such as graft-versus-host disease, leading to a speedy recovery of hematopoiesis. To meet this clinical demand, a fast MSC
Autor:
Ivano Di Stefano, André Gothot, Nathalie Meuris, Yves Beguin, Emilie Castermans, Olivier Giet, Laurence Pirson, Roland Greimers, Frédéric Baron
Publikováno v:
Stem cells (Dayton, Ohio). 24(7)
There is potential interest for combining allogeneic hematopoietic cell transplantation (HCT), and particularly allogeneic HCT with a nonmyeloablative regimen, to the tyrosine kinase inhibitor imatinib (Glivec; Novartis, Basel, Switzerland, http://ww
Autor:
Joachim Oswald, Katrin Salchert, Christine Steudel, Christian Thiede, Martin Bornhäuser, Gerhard Ehninger, Carsten Werner, Brigitte Joergensen
Publikováno v:
Stem cells (Dayton, Ohio). 24(3)
CD34+ hematopoietic stem/progenitor cells (HSCs) reside in the bone marrow in close proximity to the endosteal bone surface, surrounded by osteoblasts, stromal cells, and various extracellular matrix molecules. We used a bioartificial matrix of fibri
Autor:
Ralph M. Böhmer
Publikováno v:
Stem cells (Dayton, Ohio). 22(2)
Autocrine/paracrine transforming growth factor beta (TGF-beta) is an important regulator of stem cell quiescence and generally suppresses stem cell proliferation. However, we show here that during the first few days of an erythroid cell culture from
Autor:
Hyo Seop Ahn, Hyun Ok Kim, Yoo Hong Min, Mi Kyung Lee, Hae Kyung Park, Tae Jung Kwon, Seock Ah Im, Jeong Hae Kie, Hyung Lae Kim, Kyung Ha Ryu, Hae Young Park, Myeong Heon Shin, Yu Jin Jung, Wha Soon Chung, So Youn Woo, Ju Young Seoh, Woo Ick Yang
Publikováno v:
Stem cells (Dayton, Ohio). 20(1)
Thrombopoietin (TPO) is widely used for ex vivo expansion of hematopoietic stem cells. Previously, we have reported that TPO induces a characteristic pattern of apoptosis, and the TPO-induced apoptosis is closely associated with megakaryocyte (MK) di