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Publikováno v:
Stem cells (Dayton, Ohio). 36(7)
To explore the effects and mechanisms of paracrine factors secreted from human adipose mesenchymal stem cell (hAdMSCs) that are activated by hypoxia on radioprotection against irradiation-induced salivary hypofunction in subjects undergoing radiother
Publikováno v:
Stem cells (Dayton, Ohio). 35(5)
Adult stem cells play a critical role in the maintenance of tissue homeostasis and prevention of aging. While the regenerative potential of stem cells with low cellular turnover, such as adipose-derived stem cells (ASCs), is increasingly recognized,
Publikováno v:
Stem Cells (Dayton, Ohio)
Defining the signaling mechanisms that regulate the fate of adult stem cells is an essential step toward their use in regenerative medicine. Platelet-derived growth factor receptor (PDGFR) signaling plays a crucial role in specifying mesenchymal stem
Autor:
Ping Dong, Qiuchen Li, Ran Xiao, Zhigang Yang, Dongying Wu, Xin Fu, Xia Liu, Li Yan, Shize Ma, Ning Kang
Publikováno v:
Stem cells (Dayton, Ohio). 33(9)
The advent of mesenchymal stem cell (MSC)-based therapies has been an exciting innovation for the treatment of degenerative and inflammatory diseases. However, the surface markers that accurately reflect the self-renewal and differentiation potential
Autor:
Anne Bouloumié, Jason S. Iacovoni, Benjamin Castel, Muriel Coupaye, Frédérique Gaits-Iacovoni, Fanny Volat, Nathalie Boulet, Pauline Decaunes, Séverine Ledoux, A. Remaury, Chloé Belles, Christophe Heymes, Pascual Ferrara, David Estève, Max Lafontan, Jean Galitzky, Alexia Zakaroff-Girard
Publikováno v:
Stem cells (Dayton, Ohio). 33(4)
Obesity-associated inflammation contributes to the development of metabolic diseases. Although brite adipocytes have been shown to ameliorate metabolic parameters in rodents, their origin and differentiation remain to be characterized in humans. Nati
Autor:
Yi-Chun, Kuo, Tzu-Hao, Chang, Wei-Tse, Hsu, Jing, Zhou, Hsiao-Hui, Lee, Jennifer, Hui-Chun Ho, Shu, Chien, Oscar Kuang-Sheng, Lee, Oscar, Kuang-Sheng
Publikováno v:
Stem cells (Dayton, Ohio). 33(2)
Shear stress stimuli differentially regulate cellular functions based on the pattern, magnitude as well as duration of the flow. Shear stress can modify intracellular kinase activities and cytoskeleton reorganization to result in changes of cell beha
Autor:
Masako Miura, Yasuo Miura, Satoshi Yoshioka, Yayoi Higashi, Akihiro Tamura, Atsushi Sato, Masaki Iwasa, Hideyo Hirai, Yoshihiro Hayashi, Eishi Ashihara, Taira Maekawa, Hisayuki Yao, Tatsuo Ichinohe, Hitomi Kaneko, Terutoshi Hishita
Publikováno v:
Stem cells (Dayton, Ohio). 32(8)
Parathyroid hormone (PTH) stimulates hematopoiesis in mouse models. The involvement of osteoblasts in this process has been well investigated; however, the effects of PTH on human hematopoiesis and bone marrow mesenchymal stromal cells (BM-MSCs) are
Autor:
Wonil Oh, Dong-Hyung Cho, Yoon Sun Yang, Sang Young Jeong, Jong Wook Chang, Gonhyung Kim, Hong Bae Jeon, Donghyun Kim, Jung-Ro Yoon, Soon-Jae Kwon, Soo Jin Choi, Jueun Ha, Hye Jin Jin, Jae-Sung Kim
Publikováno v:
Stem cells (Dayton, Ohio). 31(10)
Increasing evidence indicates that the secretome of mesenchymal stem cells (MSCs) has therapeutic potential for the treatment of various diseases, including cartilage disorders. However, the paracrine mechanisms underlying cartilage repair by MSCs ar
Autor:
Hé Lène Schlecht, Peter I. Sipos, Colin P. Sibley, Mark Wareing, Carl A. Hubel, Stephane L. Bourque, Willem Rens, I.P. Crocker, Christina Hayward, Xiaohu Fan, Philip N. Baker, Sandra T. Davidge
Publikováno v:
Stem Cells (Dayton, Ohio)
The potency of adult-derived circulating progenitor endothelial colony forming cells (ECFCs) is drastically surpassed by their fetal counterparts. Human pregnancy is associated with robust intensification of blood flow and vascular expansion in the u
Autor:
Brigitte L. Arduini, Ali H. Brivanlou
Publikováno v:
Stem cells (Dayton, Ohio). 30(10)
Transcription factor Foxd3 has been described in model systems as a key member of the pluripotency network in mice as well as being involved in the formation of many critical vertebrate cell types in vivo. Yet virtually nothing is known about roles o