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Publikováno v:
Stem cells (Dayton, Ohio). 35(5)
Adult stem cells play a critical role in the maintenance of tissue homeostasis and prevention of aging. While the regenerative potential of stem cells with low cellular turnover, such as adipose-derived stem cells (ASCs), is increasingly recognized,
Autor:
Renato Romagnoli, Stefania Bruno, Maria Chiara Deregibus, Barbara Cisterna, Ciro Tetta, Giovanni Camussi, Claudia Cavallari, Maria Beatriz Herrera, Valentina Fonsato, Mauro Salizzoni, Federica Collino
Publikováno v:
Stem Cells (Dayton, Ohio)
Microvesicles (MVs) play a pivotal role in cell-to-cell communication. Recent studies demonstrated that MVs may transfer genetic information between cells. Here, we show that MVs derived from human adult liver stem cells (HLSC) may reprogram in vitro
Publikováno v:
Stem Cells (Dayton, Ohio)
Defining the signaling mechanisms that regulate the fate of adult stem cells is an essential step toward their use in regenerative medicine. Platelet-derived growth factor receptor (PDGFR) signaling plays a crucial role in specifying mesenchymal stem
Autor:
Ping Dong, Qiuchen Li, Ran Xiao, Zhigang Yang, Dongying Wu, Xin Fu, Xia Liu, Li Yan, Shize Ma, Ning Kang
Publikováno v:
Stem cells (Dayton, Ohio). 33(9)
The advent of mesenchymal stem cell (MSC)-based therapies has been an exciting innovation for the treatment of degenerative and inflammatory diseases. However, the surface markers that accurately reflect the self-renewal and differentiation potential
Autor:
Louise E. Purton, Sharon Paton, Romana Panagopoulos, Koichi Matsuo, John D. Hayball, Andrew C.W. Zannettino, Thao Nguyen, Agnieszka Arthur, Stan Gronthos
Publikováno v:
Stem cells (Dayton, Ohio). 33(9)
The tyrosine kinase receptor, EphB4, mediates cross-talk between stromal and hematopoietic populations during bone remodeling, fracture repair and arthritis, through its interactions with the ligand, ephrin-B2. This study demonstrated that transgenic
Autor:
Christopher M. Ward, Joe M. Segal, Nicoletta Bobola, Kate Hawkins, Sarah Ritson, Lisa Mohamet, Natalie J Miazga, Francesca Soncin, Catherine L.R. Merry, Maria Keramari
Publikováno v:
Stem cells (Dayton, Ohio). 32(11)
Mouse embryonic stem cells (mESCs) and epiblast stem cells represent the naïve and primed pluripotent states, respectively. These cells self-renew via distinct signaling pathways and can transition between the two states in the presence of appropria
Autor:
Juana San Emeterio, Isabel Fariñas, Gloria Martínez, Anxo Vidal, Pilar González-Gómez, Helena Mira, Santiago Negueruela, Zoraida Andreu, Rafael Hortigüela, Sacri R. Ferrón, Dieter Chichung Lie, Muhammad Amir Khan
Publikováno v:
Stem cells (Dayton, Ohio). 33(1)
Members of the cyclin-dependent kinase (CDK)-inhibitory protein (CIP)/kinase-inhibitory protein (KIP) family of cyclin-dependent kinase inhibitors regulate proliferation and cell cycle exit of mammalian cells. In the adult brain, the CIP/KIP protein
Publikováno v:
Stem Cells
The cornea is covered by a stratified epithelium that is renewed by stem cells located in the peripheral region of the cornea known as the limbus. This stroma of the limbus contains stromal keratocytes that, when expanded in culture, are termed limba
Autor:
Martin Grünert, C. Michael Jones, Torben Helledie, Ling Ling, Claire A. Canning, Christian Dombrowski, James Hoi Po Hui, Simon M. Cool, Andre J. van Wijnen, Victor Nurcombe
Publikováno v:
Stem Cells
Signaling through fibroblast growth factor receptor one (FGFR1) is a known inducer of proliferation in both embryonic and human adult mesenchymal stem cells (hMSCs) and positively regulates maintenance of stem cell viability. Leveraging the mitogenic
Autor:
Bryan J. Heard, Quinn Harris, Colleen S. Kondo, Jonathan Seto, Roman Krawetz, Kate O'Brien, David A. Hart, Poh S. Lee
Publikováno v:
Stem cells (Dayton, Ohio). 31(10)
Osteoarthritis (OA) is a multifactorial, often progressive, painful disease. OA often progresses with an apparent irreversible loss of articular cartilage, exposing underlying bone, resulting in pain and loss of mobility. This cartilage loss is thoug