Zobrazeno 1 - 10
of 499
pro vyhledávání: ''
Autor:
Dafni Chondronasiou, Jaime Martínez de Villarreal, Elena Melendez, Cian J. Lynch, Natalia del Pozo, Marta Kovatcheva, Mònica Aguilera, Neus Prats, Francisco X. Real, Manuel Serrano
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Universidad de Barcelona
Differentiated cells can be converted into pluripotent stem cells by expressing the transcription factors OCT4, SOX2, KLF4, and MYC (OSKM) in a process known as reprogramming. Here, using single-cell RNA sequencing of pancreas undergoing reprogrammin
Autor:
Sudhanshu Yadav, Antonio Garrido, M. Carmen Hernández, Juan C. Oliveros, Vicente Pérez-García, Mario F. Fraga, Ana C. Carrera
Publikováno v:
WOS:000873961800006
The mechanism governing the transition of human embryonic stem cells (hESCs) toward differentiated cells is only partially understood. To explore this transition, the activity and expression of the ubiquitous phosphatidylinositol 3-kinase (PI3Kα and
Publikováno v:
Stem Cell Reports. 17:2167-2171
In a recently published study, Xu et al. used two surface markers, CLSTN2 and PTPRO, to generate highly purified donor dopaminergic neurons and achieved stable and predictable therapeutic outcomes by transplantation into the brain of PD animal models
Autor:
Bayardo I. Garay, Sophie Givens, Phablo Abreu, Man Liu, Doğacan Yücel, June Baik, Noah Stanis, Taylor M. Rothermel, Alessandro Magli, Juan E. Abrahante, Natalya A. Goloviznina, Hossam A.N. Soliman, Neha R. Dhoke, Michael Kyba, Patrick W. Alford, Samuel C. Dudley, Jop H. van Berlo, Brenda Ogle, Rita R.C. Perlingeiro
Publikováno v:
Stem Cell Reports. 17:2005-2022
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) provide great opportunities for mechanistic dissection of human cardiac pathophysiology; however, hiPSC-CMs remain immature relative to the adult heart. To identify novel signalin
Autor:
Amy L. Pitstick, Holly M. Poling, Nambirajan Sundaram, Phillip L. Lewis, Daniel O. Kechele, J. Guillermo Sanchez, Melissa A. Scott, Taylor R. Broda, Michael A. Helmrath, James M. Wells, Christopher N. Mayhew
Publikováno v:
Stem Cell Reports. 17:1889-1902
A major technical limitation hindering the widespread adoption of human pluripotent stem cell (hPSC)-derived gastrointestinal (GI) organoid technologies is the need for de novo hPSC differentiation and dependence on spontaneous morphogenesis to produ
Autor:
Yuta Tsujisaka, Takeshi Hatani, Chikako Okubo, Ryo Ito, Azuma Kimura, Megumi Narita, Kazuhisa Chonabayashi, Shunsuke Funakoshi, Antonio Lucena-Cacace, Taro Toyoda, Kenji Osafune, Takeshi Kimura, Hirohide Saito, Yoshinori Yoshida
Publikováno v:
Stem Cell Reports. 17:1772-1785
For regenerative cell therapies using pluripotent stem cell (PSC)-derived cells, large quantities of purified cells are required. Magnetic-activated cell sorting (MACS) is a powerful approach to collect target antigen-positive cells; however, it rema
Autor:
Yanling Zhu, Zhishuai Zhang, Nana Fan, Ke Huang, Hao Li, Jiaming Gu, Quanjun Zhang, Zhen Ouyang, Tian Zhang, Jun Tang, Yanqi Zhang, Yangyang Suo, Chengdan Lai, Jiaowei Wang, Junwei Wang, Yongli Shan, Mingquan Wang, Qianyu Chen, Tiancheng Zhou, Liangxue Lai, Guangjin Pan
Publikováno v:
Stem Cell Reports. 17:1059-1069
Obtaining functional human cells through interspecies chimerism with human pluripotent stem cells (hPSCs) remains unsuccessful due to its extremely low efficiency. Here, we show that hPSCs failed to differentiate and contribute teratoma in the presen
Autor:
Rose Ann G. Franco, Eamonn McKenna, Pamela G. Robey, Md. Shaffiulah Shajib, Ross W. Crawford, Michael R. Doran, Kathryn Futrega
Publikováno v:
Stem Cell Reports. 17:616-632
Bone morphogenetic protein (BMP) cascades are upregulated during bone marrow-derived stromal cell (BMSC) chondrogenesis, contributing to hypertrophy and preventing effective BMSC-mediated cartilage repair. Previous work demonstrated that a proprietar
Autor:
Claudia Raggi, Marie-Agnès M’Callum, Quang Toan Pham, Perrine Gaub, Silvia Selleri, Nissan Vida Baratang, Chenicka Lyn Mangahas, Gaël Cagnone, Bruno Reversade, Jean-Sébastien Joyal, Massimiliano Paganelli
Publikováno v:
Stem Cell Reports. 17:584-598
Pluripotent stem cell (PSC)-derived hepatocyte-like cells (HLCs) have shown great potential as an alternative to primary human hepatocytes (PHHs) for in vitro modeling. Several differentiation protocols have been described to direct PSCs toward the h
Autor:
Mutsumi Kobayashi, Misato Kobayashi, Junko Odajima, Keiko Shioda, Young Sun Hwang, Kotaro Sasaki, Pranam Chatterjee, Christian Kramme, Richie E. Kohman, George M. Church, Amanda R. Loehr, Robert S. Weiss, Harald Jüppner, Joanna J. Gell, Ching C. Lau, Toshi Shioda
Publikováno v:
Stem Cell Reports. 17:507-521
In vitro expansion of human primordial germ cell-like cells (hPGCLCs), a pluripotent stem cell-derived PGC model, has proved challenging due to rapid loss of primordial germ cell (PGC)-like identity and limited cell survival/proliferation. Here, we d