Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Franz Koenig"'
Publikováno v:
Statistics in Medicine. 37:4335-4352
Population heterogeneity is frequently observed among patients' treatment responses in clinical trials because of various factors such as clinical background, environmental, and genetic factors. Different subpopulations defined by those baseline fact
Publikováno v:
Statistics in Medicine. 37:3387-3402
Adaptive enrichment designs have recently received considerable attention as they have the potential to make drug development process for personalized medicine more efficient. Several statistical approaches have been proposed so far in the literature
Publikováno v:
Statistics in medicine. 37(24)
Adaptive enrichment designs have recently received considerable attention as they have the potential to make drug development process for personalized medicine more efficient. Several statistical approaches have been proposed so far in the literature
Publikováno v:
Statistics in Medicine. 28:1181-1217
Adaptive designs play an increasingly important role in clinical drug development. Such designs use accumulating data of an ongoing trial to decide how to modify design aspects without undermining the validity and integrity of the trial. Adaptive des
Publikováno v:
Statistics in Medicine. 28:1321-1338
It is common for a number of potentially effective treatments to be available for clinical evaluation. Limitations on resources mean that this inevitably leads to a decision as to how many, and which, treatments should be considered for inclusion in
Autor:
Cornelia Dunger-Baldauf, Michael Branson, Martin Posch, Werner Brannath, Franz Koenig, Peter Bauer
Publikováno v:
Statistics in Medicine. 24:3697-3714
Integrating selection and confirmation phases into a single trial can expedite the development of new treatments and allows to use all accumulated data in the decision process. In this paper we review adaptive treatment selection based on combination
Publikováno v:
Statistics in medicine. 28(9)
It is common for a number of potentially effective treatments to be available for clinical evaluation. Limitations on resources mean that this inevitably leads to a decision as to how many, and which, treatments should be considered for inclusion in
Publikováno v:
Statistics in Medicine.
We consider the situation where in a first stage of a clinical trial several treatments are compared with a single control and the 'best' treatment(s) are selected in an interim analysis to be carried on to the second stage. We quantify the mean bias
Publikováno v:
Statistics in medicine. 27(10)
Clinical trials incorporating treatment selection at pre-specified interim analyses allow to integrate two clinical studies into a single, confirmatory study. In an adaptive interim analysis, treatment arms are selected based on interim data as well
Autor:
Peter Bauer, Franz Koenig
Publikováno v:
Statistics in medicine. 25(1)
If an interim analysis is performed during a trial it is tempting to determine the conditional power to reach a rejection in the trial given the observed results in the interim analysis. Since the true effect size is unknown the conditional power may