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Autor:
Masafumi Shimoda, Naofumi Kagara, Tomonori Tanei, Atsushi Shimomura, Yasuto Naoi, Saki Matsui, Kenzo Shimazu, Seung Jin Kim, Chieko Mishima, Shinzaburo Noguchi
Publikováno v:
SpringerPlus
The aim of the present study was to investigate the promoter methylation status of TRIM9 in breast cancer and to determine the presence of TRIM9-methylated circulating tumor DNA (ctDNA) in plasma. Bisulfite sequencing with a next generation sequencer
Autor:
Pamala A. Jacobson, David Potter, Daniel A. Duprez, Ryan Shanley, Douglas Yee, Anne H. Blaes, Todd E. DeFor, Tufia C. Haddad, Heather Beckwith, Kinjal Sanghavi
Publikováno v:
SpringerPlus
Purpose Doxorubicin (DOX) chemotherapy can cause cardiac complications. Angiotensin converting enzyme inhibitors (ACEI) may protect against these complications. We performed a pharmacokinetics (PK) study to determine whether DOX levels are altered in
Autor:
Sobuhi Iqbal, N.K. Shukla, Suryanarayana S.V. Deo, Surabhi Sharma, Ajay Gogia, Vinod Raina, Sreenivas Vishnubhatla, Sandeep Mathur
Publikováno v:
SpringerPlus
The aim of our study was to look for alternative predictive biomarkers for breast cancer management in limited resource setup. A comprehensive analysis of circulating cell-free DNA (CCFD) in serum at baseline was performed to assess its prognostic po
Autor:
Benford Mafuvadze, Sandy Goyette, Salman M. Hyder, Matthew Cook, Yayun Liang, Cynthia Besch-Williford
Publikováno v:
SpringerPlus
Purpose Clinical trials and epidemiological evidence have shown that combined estrogen/progestin hormone replacement therapy, but not estrogen therapy alone, increases breast cancer risk in post-menopausal women. Previously we have shown that natural
Autor:
Felicity Leslie, Haryana M. Dhillon, Philip Beale, Inger Olesen, Anneliese Rittau, Jane Beith, Stephen Clarke, Anne Warby, A. Sullivan, Janette L. Vardy, Anne Hamilton, Andrew J. McLachlan
Publikováno v:
SpringerPlus
Women receiving treatment for breast cancer commonly ingest herbal medicines. Little is known about the potential for herb-drug interactions in this population. The aim of this study is to investigate the effect of ginkgo biloba co-administration on
Publikováno v:
SpringerPlus
Background Expression of transcription-factors as Slug and Sox9 was recently described to determine mammary stem-cell state. Sox10 was previously shown to be present also in breast cancer. Protein overexpression of Slug, Sox9 and Sox10 were associate
Autor:
Gregory R. Pond, Huijun Zhao, Eitan Amir, Lisa Vandermeer, Christina L. Addison, Mark Clemons, Sasha Mazzarello, Robyn Goldstein
Publikováno v:
SpringerPlus
While de-escalation of bisphosphonates from 4 to 12-weekly dosing has been shown to be clinically non-inferior to standard dosing, there is evidence the de-escalation is associated with increased bone turnover biomarkers. Here we evaluated the effect
Autor:
Georg F. Weber, Franz Hartung
Publikováno v:
SpringerPlus
Purpose: Despite a sizeable and continuously growing literature on osteopontin and cancer the molecule has not yet found entry into clinical diagnostics. Our identification of spliced variants that are more specific for cancer than the full-length tr
Autor:
Amy E. Hanlon Newell, Megan L. Troxell, Edward J. Keenan, Zhi Hu, Susan B. Olson, Shiuh Wen Luoh, Paul T. Spellman, Betsy Ramsey, Koei Chin
Publikováno v:
SpringerPlus
Background Testing for human epidermal growth factor receptor-2 (HER-2) in breast cancer is performed by either immunohistochemistry (IHC) or in situ hybridization (ISH). The growth factor receptor-bound protein-7 (GRB7) gene is in close proximity to