Zobrazeno 1 - 10
of 29
pro vyhledávání: ''
Autor:
Jiabin Yuan, Jingfeng Li, Xiaoming Li, Fei Wang, Jinhui Wu, Shu Liu, Weina Zheng, Jiaoyang Zheng, Chao Wang, Zhicai Shi, Xiong Miao
Publikováno v:
Spine. 46:E234-E242
Study design An in vitro biological study. Objective The aim of this study was to explore the role of bone morphogenetic protein-2 (BMP-2) in the regulation of osteoclast-mediated osteolysis, and the possible mechanism involving BMP-2 and nuclear fac
Publikováno v:
Spine. 45:E1216-E1224
Study design mRNA analysis. Objective The aim of this study was to identify differentially expressed genes (DEGs) in disc degeneration, analyze the potential biological functions of DEGs, and screen for a new target to prevent the degeneration. Summa
Publikováno v:
Spine. 45:292-299
Study design In vitro studies of the role of 17β-estradiol (E2) and its possible targets in intervertebral disc degeneration (IDD). Objective To define the regulatory role of E2 in IDD and the potential mechanisms. Summary of background data IDD has
Autor:
Ruud A. Bank, Jelena Popov-Celeketic, Saskia G M Plomp, Anita Krouwels, F. Cumhur Oner, Wouter J.A. Dhert, Laura B. Creemers
Publikováno v:
SPINE, 43(5), 307-315. LIPPINCOTT WILLIAMS & WILKINS
Study Design. An in vitro study using human degenerated nucleus pulposus cells.Objective. To determine the effect of osmolality and different osmolytes on the regeneration by human nucleus pulposus cells through gene expression and extracellular matr
Publikováno v:
Spine. 42:E757-E766
STUDY DESIGN Experimental in vivo and in vitro study of intervertebral disc (IVD) degeneration and the mechanism exploration. OBJECTIVE This report aims to verify the expression of Sirt1 in IVD degeneration of different grades and explore its potenti
Publikováno v:
Spine. 42:E61-E70
Study design The macrophage inhibition factor (MIF)-mediated CD74 dependent extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation were associated with inflammatory activity and matrix metabolism in human degenerated cartilage endplate (C
Publikováno v:
SPINE. 41:E248-E254
STUDY DESIGN In vitro experimental study. OBJECTIVE To investigate the effect of low-intensity pulsed ultrasound (LIPUS) on the extracellular matrix (ECM) synthesis of degenerative human nucleus pulposus cells and explore the molecular mechanism. SUM
Autor:
Gabriella Cs-Szabo, David Gerard, Carla R. Scanzello, Di Chen, D. Greg Anderson, Howard S. An, Yejia Zhang, Nancy Ruel, Marc Zack, Sherrill L. Adams, Peng Shi, Dessislava Markova
Publikováno v:
Spine. 39:1274-1279
Fibronectin (FN), a molecule with diverse biologic functions, can exist in multiple variants that arise from alternative splicing of a single pre-mRNA.3, 4 In most human tissues, the FN exists in up to 20 variants due to inclusion or exclusion of the
Autor:
Yubo Sun, Yin Chow, H. James Norton, Gretchen L. Hoelscher, Jane A. Ingram, Natalia Zinchenko, Edward N. Hanley, Helen E. Gruber
Publikováno v:
Spine. 35:1033-1038
Study design Micromass culture was assessed as a cell culture microenvironment for anulus cells from the human intervertebral disc. Objective To determine whether the micromass culture technique might be useful for the culture of human anulus cells.
Publikováno v:
Spine. 34:1513-1518
Study Design. Variation in abundance and structure of chondroadherin (CHAD) were studied in the extracellular matrix (ECM) of scoliotic and normal human discs. Objective. To determine whether CHAD abundance and fragmentation vary between different si