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Publikováno v:
Spine. 34:1127-1133
STUDY DESIGN: In vitro stimulation of human intervertebral disc (IVD) cells. OBJECTIVE: To investigate the oxidative/nitrosative effects of peroxynitrite on human nucleus pulposus (NP) cells. SUMMARY OF BACKGROUND DATA: Peroxynitrite is an important
Autor:
Yuichi Kasai, Ryu Iida, Koichi Masuda, Ryo Morimoto, Atsumasa Uchida, Masayoshi Sato, Koji Akeda, Toshihiko Sakakibara
Publikováno v:
Spine. 34:470-478
Study design Immunohistochemical and biochemical analyses of proteinase-activated receptor-2 (PAR-2) in rat and human intervertebral discs (IVDs). Objectives To examine the expression and function of PAR-2 in rat IVD cells, and to determine if PAR-2
Publikováno v:
Spine. 33:1951-1957
Study design Coculture of human nucleus pulposus (NP) cells and mesenchymal stem cells (MSCs) using a noncontact system. Objective To investigate the interaction between NP cells and MSCs through paracrine stimulation. Summary of background data Cell
Autor:
Jeffrey C. Wang, Chihui Chen, Elsa J. Brochmann, Ahmet Alanay, Sang Lee, Samuel S. Murray, Masashi Miyazaki, Antonia Napoli
Publikováno v:
Spine. 33:1709-1713
A prospective 8-week interventional trial employing a rat model of spinal fusion to test the effect on bone morphogenetic protein binding peptide (BBP) on rhBMP-2 induced bone healing.To determine if the addition of BBP to the collagen sponges used a
Autor:
Alex M. Aboka, James D. Kang, Gwendolyn Sowa, Rebecca K. Studer, Nam Vo, Helga I. Georgescu, Lars G. Gilbertson
Publikováno v:
Spine. 32:2827-2833
STUDY DESIGN Human nucleus pulposus cells were cultured in alginate beads and activated with IL-1 beta or TNF-alpha, with and without inhibition of p38 mitogen activated protein kinase (p38 MAPK) activity. Cell production of factors modulating the an
Autor:
Zulma Gazit, Alexander R. Vaccaro, Tsung-Ting Tsai, Todd J. Albert, Makarand V. Risbud, Keith G. Danielson, Asha Guttapalli, Joon Y. Lee, Irving M. Shapiro, Dan Gazit
Publikováno v:
Spine. 32:2537-2544
STUDY DESIGN To identify and characterize endogenous progenitor cell population from intervertebral disc. OBJECTIVE To determine if progenitor cells exist in degenerate human discs. SUMMARY OF BACKGROUND DATA Back pain, a significant source of morbid
Autor:
E. Thonar, Tong-Chuan He, Howard S. An, D. Greg Anderson, Frank M. Phillips, Daniel Pietryla, Yejia Zhang
Publikováno v:
Spine. 32:2515-2520
STUDY DESIGN An in vitro biologic study comparing the effects of a series of bone morphogenetic proteins (BMPs) and Sox9 on the extracellular matrix accumulation by bovine anulus fibrosus (AF) cells. OBJECTIVE To compare the effects of adenoviral-med
Autor:
Kei Miyamoto, Howard S. An, Koichi Masuda, Gunnar Andersson, Eugene J.-M.A. Thonar, Yoshiyuki Imai
Publikováno v:
Spine. 32:1303-1309
Study Design. In vitro assessment of the effects of recombinant human osteogenic protein-1 (rhOP-1) on the proteoglycan metabolism of human intervertebral disc cells. Objectives. To determine whether rhOP-1 is effective in stimulating the cell prolif
Autor:
Yasuchika Aoki, Carol Muehleman, Howard S. An, Koji Akeda, Koichi Masuda, Tomoatsu Kimura, Yumiko Abe, Rajeswari Pichika
Publikováno v:
Spine. 32:635-642
Study design In vitro studies of the effects of proinflammatory cytokines on the production of nerve growth factor (NGF) by human intervertebral disc (IVD) cells. Objective To determine the constitutive expression and production of NGF and the effect
Publikováno v:
Spine. 31:2036-2042
Study Design. To evaluate the in vitro interactions between human mesenchymal stem cells (MSCs) and degenerative disc cells. Objectives. To demonstrate the potential of MSCs in regulating the extracellular matrix synthesis of degenerative disc cells.