Zobrazeno 1 - 10
of 18
pro vyhledávání: ''
Autor:
Jiabin Yuan, Jingfeng Li, Xiaoming Li, Fei Wang, Jinhui Wu, Shu Liu, Weina Zheng, Jiaoyang Zheng, Chao Wang, Zhicai Shi, Xiong Miao
Publikováno v:
Spine. 46:E234-E242
Study design An in vitro biological study. Objective The aim of this study was to explore the role of bone morphogenetic protein-2 (BMP-2) in the regulation of osteoclast-mediated osteolysis, and the possible mechanism involving BMP-2 and nuclear fac
Autor:
Ruud A. Bank, Jelena Popov-Celeketic, Saskia G M Plomp, Anita Krouwels, F. Cumhur Oner, Wouter J.A. Dhert, Laura B. Creemers
Publikováno v:
SPINE, 43(5), 307-315. LIPPINCOTT WILLIAMS & WILKINS
Study Design. An in vitro study using human degenerated nucleus pulposus cells.Objective. To determine the effect of osmolality and different osmolytes on the regeneration by human nucleus pulposus cells through gene expression and extracellular matr
Publikováno v:
Spine. 42:E757-E766
STUDY DESIGN Experimental in vivo and in vitro study of intervertebral disc (IVD) degeneration and the mechanism exploration. OBJECTIVE This report aims to verify the expression of Sirt1 in IVD degeneration of different grades and explore its potenti
Autor:
Gabriella Cs-Szabo, David Gerard, Carla R. Scanzello, Di Chen, D. Greg Anderson, Howard S. An, Yejia Zhang, Nancy Ruel, Marc Zack, Sherrill L. Adams, Peng Shi, Dessislava Markova
Publikováno v:
Spine. 39:1274-1279
Fibronectin (FN), a molecule with diverse biologic functions, can exist in multiple variants that arise from alternative splicing of a single pre-mRNA.3, 4 In most human tissues, the FN exists in up to 20 variants due to inclusion or exclusion of the
Autor:
Yubo Sun, Yin Chow, H. James Norton, Gretchen L. Hoelscher, Jane A. Ingram, Natalia Zinchenko, Edward N. Hanley, Helen E. Gruber
Publikováno v:
Spine. 35:1033-1038
Study design Micromass culture was assessed as a cell culture microenvironment for anulus cells from the human intervertebral disc. Objective To determine whether the micromass culture technique might be useful for the culture of human anulus cells.
Publikováno v:
Spine. 34:1513-1518
Study Design. Variation in abundance and structure of chondroadherin (CHAD) were studied in the extracellular matrix (ECM) of scoliotic and normal human discs. Objective. To determine whether CHAD abundance and fragmentation vary between different si
Publikováno v:
Spine. 33:1951-1957
Study design Coculture of human nucleus pulposus (NP) cells and mesenchymal stem cells (MSCs) using a noncontact system. Objective To investigate the interaction between NP cells and MSCs through paracrine stimulation. Summary of background data Cell
Autor:
Alex M. Aboka, James D. Kang, Gwendolyn Sowa, Rebecca K. Studer, Nam Vo, Helga I. Georgescu, Lars G. Gilbertson
Publikováno v:
Spine. 32:2827-2833
STUDY DESIGN Human nucleus pulposus cells were cultured in alginate beads and activated with IL-1 beta or TNF-alpha, with and without inhibition of p38 mitogen activated protein kinase (p38 MAPK) activity. Cell production of factors modulating the an
Autor:
Zulma Gazit, Alexander R. Vaccaro, Tsung-Ting Tsai, Todd J. Albert, Makarand V. Risbud, Keith G. Danielson, Asha Guttapalli, Joon Y. Lee, Irving M. Shapiro, Dan Gazit
Publikováno v:
Spine. 32:2537-2544
STUDY DESIGN To identify and characterize endogenous progenitor cell population from intervertebral disc. OBJECTIVE To determine if progenitor cells exist in degenerate human discs. SUMMARY OF BACKGROUND DATA Back pain, a significant source of morbid
Autor:
Kei Miyamoto, Howard S. An, Koichi Masuda, Gunnar Andersson, Eugene J.-M.A. Thonar, Yoshiyuki Imai
Publikováno v:
Spine. 32:1303-1309
Study Design. In vitro assessment of the effects of recombinant human osteogenic protein-1 (rhOP-1) on the proteoglycan metabolism of human intervertebral disc cells. Objectives. To determine whether rhOP-1 is effective in stimulating the cell prolif