Zobrazeno 1 - 10
of 16
pro vyhledávání: ''
Autor:
Jiabin Yuan, Jingfeng Li, Xiaoming Li, Fei Wang, Jinhui Wu, Shu Liu, Weina Zheng, Jiaoyang Zheng, Chao Wang, Zhicai Shi, Xiong Miao
Publikováno v:
Spine. 46:E234-E242
Study design An in vitro biological study. Objective The aim of this study was to explore the role of bone morphogenetic protein-2 (BMP-2) in the regulation of osteoclast-mediated osteolysis, and the possible mechanism involving BMP-2 and nuclear fac
Publikováno v:
Spine. 45:E1216-E1224
Study design mRNA analysis. Objective The aim of this study was to identify differentially expressed genes (DEGs) in disc degeneration, analyze the potential biological functions of DEGs, and screen for a new target to prevent the degeneration. Summa
Autor:
Ruud A. Bank, Jelena Popov-Celeketic, Saskia G M Plomp, Anita Krouwels, F. Cumhur Oner, Wouter J.A. Dhert, Laura B. Creemers
Publikováno v:
SPINE, 43(5), 307-315. LIPPINCOTT WILLIAMS & WILKINS
Study Design. An in vitro study using human degenerated nucleus pulposus cells.Objective. To determine the effect of osmolality and different osmolytes on the regeneration by human nucleus pulposus cells through gene expression and extracellular matr
Publikováno v:
Spine. 42:E757-E766
STUDY DESIGN Experimental in vivo and in vitro study of intervertebral disc (IVD) degeneration and the mechanism exploration. OBJECTIVE This report aims to verify the expression of Sirt1 in IVD degeneration of different grades and explore its potenti
Publikováno v:
SPINE. 41:E248-E254
STUDY DESIGN In vitro experimental study. OBJECTIVE To investigate the effect of low-intensity pulsed ultrasound (LIPUS) on the extracellular matrix (ECM) synthesis of degenerative human nucleus pulposus cells and explore the molecular mechanism. SUM
Autor:
Yubo Sun, Yin Chow, H. James Norton, Gretchen L. Hoelscher, Jane A. Ingram, Natalia Zinchenko, Edward N. Hanley, Helen E. Gruber
Publikováno v:
Spine. 35:1033-1038
Study design Micromass culture was assessed as a cell culture microenvironment for anulus cells from the human intervertebral disc. Objective To determine whether the micromass culture technique might be useful for the culture of human anulus cells.
Publikováno v:
Spine. 34:1127-1133
STUDY DESIGN: In vitro stimulation of human intervertebral disc (IVD) cells. OBJECTIVE: To investigate the oxidative/nitrosative effects of peroxynitrite on human nucleus pulposus (NP) cells. SUMMARY OF BACKGROUND DATA: Peroxynitrite is an important
Autor:
Yuichi Kasai, Ryu Iida, Koichi Masuda, Ryo Morimoto, Atsumasa Uchida, Masayoshi Sato, Koji Akeda, Toshihiko Sakakibara
Publikováno v:
Spine. 34:470-478
Study design Immunohistochemical and biochemical analyses of proteinase-activated receptor-2 (PAR-2) in rat and human intervertebral discs (IVDs). Objectives To examine the expression and function of PAR-2 in rat IVD cells, and to determine if PAR-2
Autor:
Alex M. Aboka, James D. Kang, Gwendolyn Sowa, Rebecca K. Studer, Nam Vo, Helga I. Georgescu, Lars G. Gilbertson
Publikováno v:
Spine. 32:2827-2833
STUDY DESIGN Human nucleus pulposus cells were cultured in alginate beads and activated with IL-1 beta or TNF-alpha, with and without inhibition of p38 mitogen activated protein kinase (p38 MAPK) activity. Cell production of factors modulating the an
Autor:
Zulma Gazit, Alexander R. Vaccaro, Tsung-Ting Tsai, Todd J. Albert, Makarand V. Risbud, Keith G. Danielson, Asha Guttapalli, Joon Y. Lee, Irving M. Shapiro, Dan Gazit
Publikováno v:
Spine. 32:2537-2544
STUDY DESIGN To identify and characterize endogenous progenitor cell population from intervertebral disc. OBJECTIVE To determine if progenitor cells exist in degenerate human discs. SUMMARY OF BACKGROUND DATA Back pain, a significant source of morbid