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Autor:
Alexei Verkhratsky, Peter Illes, Na Xie, Zhao Huang, Yong Tang, Beáta Sperlágh, Shu-Guang Yu, Francesco Di Virgilio, Henning Ulrich, Alexey Semyanov, Canhua Huang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-20 (2021)
Signal Transduction and Targeted Therapy
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Signal Transduction and Targeted Therapy
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Purines and their derivatives, most notably adenosine and ATP, are the key molecules controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these purines support, as chemical messengers, purinergic transmission throughout ti
Autor:
Yi Li, Bin Sheng, Zichao Wei, Zhiyu Wang, Zhihua Liu, Yanchun Ma, Bin Yang, Xiaojun Peng, Yongping Cui
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-3 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-12 (2020)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Nicotinamide adenine dinucleotide phosphate (NADPH) is an essential electron donor in all organisms, and provides the reducing power for anabolic reactions and redox balance. NADPH homeostasis is regulated by varied signaling pathways and several met
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-17 (2020)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
SOX2 is a well-characterized pluripotent factor that is essential for stem cell self-renewal, reprogramming, and homeostasis. The cellular levels of SOX2 are precisely regulated by a complicated network at the levels of transcription, post-transcript
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-11 (2020)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
NUSAP1, which is a microtubule-associated protein involved in mitosis, plays essential roles in diverse biological processes, especially in cancer biology. In this study, NUSAP1 was found to be overexpressed in GBM tissues in a grade-dependent manner
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-3 (2020)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Autor:
Qun-Ying Lei, Yifan Zhang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-2 (2020)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Here, we utilized spontaneous models of pancreatic and lung cancer to examine how neoantigenicity shapes tumor immunity and progression. As expected, neoantigen expression during lung adenocarcinoma development leads to T cell-mediated immunity and d