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Publikováno v:
Seminars in Thrombosis and Hemostasis. 46:872-886
Combined oral contraceptives (COCs) induce several changes in the levels of coagulation factors. The levels of procoagulant factors are often increased, while levels of anticoagulant factors are decreased. Fibrinolysis is also affected, even if the e
Autor:
Emily Reynen, Paula D. James
Publikováno v:
Seminars in Thrombosis and Hemostasis. 42:717-723
von Willebrand disease (VWD) is a common, inherited bleeding disorder. There are three main types of VWD, which result in a quantitative or qualitative deficiency in von Willebrand factor (VWF) and in severe cases, also Factor VIII (FVIII). The sever
Autor:
Zuzana Snahnicanova, Jan Stasko, Zora Lasabova, Tomas Simurda, Juraj Sokol, Peter Kubisz, Dusan Loderer
Publikováno v:
Seminars in Thrombosis and Hemostasis. 42:455-458
We readwith great interest the topical article by deMoerloose et al1 in Seminars in Thrombosis and Hemostasis regarding congenital afibrinogenemia. Accordingly, we recently corresponded anovelmutation in an afibrinogenemicpatientwith a proposed new p
Autor:
Anna K. Kopec, James P. Luyendyk
Publikováno v:
Seminars in Thrombosis and Hemostasis. 42:397-407
Strong experimental evidence indicates that components of the hemostatic system, including thrombin, exacerbate diverse features of experimental liver disease. Clinical studies have also begun to address this connection and some studies have suggeste
Publikováno v:
Seminars in Thrombosis and Hemostasis. 42:133-146
Congenital von Willebrand disease (VWD) and acquired von Willebrand syndrome (AVWS) reflect conditions caused by von Willebrand factor (VWF) deficiency and/or defects. VWD is the most common inherited bleeding disorder and AVWS arises from a variety
Publikováno v:
Seminars in Thrombosis and Hemostasis. 42:087-092
The results of lupus anticoagulant (LA), antithrombin (AT), protein C (PC), and protein S (PS) testing, and the values of von Willebrand factor antigen (VWF:Ag) are important in diagnosis and therapeutic monitoring of thrombosis and hemostasis diseas
Publikováno v:
Seminars in Thrombosis and Hemostasis. 41:708-717
It is generally accepted that the initial event in coagulation and intravascular thrombus formation is the exposure of the flowing blood to cell-surface protein, such as tissue factor (TF). Vascular injury and/or atherosclerotic plaque complication i
Autor:
Barbara A. Konkle
Publikováno v:
Seminars in Thrombosis and Hemostasis. 40:640-644
von Willebrand factor (VWF) plays critical roles in initiating primary hemostasis and extending the half-life of coagulation factor VIII in circulation. VWF levels increase with age and elevated levels are associated with an increased risk of venous
Publikováno v:
Seminars in Thrombosis and Hemostasis. 40:621-633
The incidence of venous thromboembolism (VTE) is well recognized to increase with aging. Concurrently, the plasma concentrations of many coagulation factors (e.g., fibrinogen, factor [F] V, FVII, FVIII, and FIX) increase with aging, as does von Wille
Autor:
Hau C. Kwaan
Publikováno v:
Seminars in Thrombosis and Hemostasis. 40:585-591
Great advances have been made in our understanding of the fibrinolytic system from the initial discovery of proteolysis of fibrin by plasmin to the multifaceted and complex role of the plasminogen-plasmin (P-P) system. We now know that the P-P system