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Publikováno v:
Seminars in Cell & Developmental Biology. 133:123-134
Stem cells can generate a diversity of cell types during development, regeneration and adult tissue homeostasis. Differentiation changes not only the cell fate in terms of gene expression but also the physical properties and functions of cells, e.g.
Autor:
Navin Gupta, Ryuji Morizane
Publikováno v:
Semin Cell Dev Biol
Kidney organoid technology has led to a renaissance in kidney developmental biology. The complex underpinnings of mammalian kidney development have provided a framework for the generation of kidney cells and tissues from human pluripotent stem cells.
Developmental principles informing human pluripotent stem cell differentiation to cartilage and bone
Autor:
Paul A, Humphreys, Fabrizio E, Mancini, Miguel J S, Ferreira, Steven, Woods, Leona, Ogene, Susan J, Kimber
Publikováno v:
Seminars in Cell & Developmental Biology. 127:17-36
Human pluripotent stem cells can differentiate into any cell type given appropriate signals and hence have been used to research early human development of many tissues and diseases. Here, we review the major biological factors that regulate cartilag
Publikováno v:
Seminars in Cell & Developmental Biology. 123:14-21
Postmenopausal osteoporosis is a systemic disease characterized by the loss of bone mass and increased bone fracture risk largely resulting from significantly reduced levels of the hormone estrogen after menopause. Besides the direct negative effects
Publikováno v:
Seminars in Cell & Developmental Biology
Macrophages are the dominant immune cell types in the adipose tissue, the liver or the aortic wall and they were originally believed to mainly derived from monocytes to fuel tissue inflammation in cardiometabolic diseases. However, over the last deca
Publikováno v:
Semin Cell Dev Biol
Congenital Heart Disease (CHD), malformations of the heart present at birth, is the most common class of life-threatening birth defect (Hoffman (1995) [1] , Gelb (2004) [2] , Gelb (2014) [3] ). A major research challenge is to elucidate the genetic d
Publikováno v:
Seminars in Cell & Developmental Biology
Oligodendrocyte precursor cells (OPCs) originate in localized germinal zones in the embryonic neural tube, then migrate and proliferate to populate the entire central nervous system, both white and gray matter. They divide and generate myelinating ol
Autor:
Chi Ma, Peter R. Hoffmann
Publikováno v:
Semin Cell Dev Biol
Selenium (Se) is an essential micronutrient that plays a key role in regulating the immune system. T cells are of particular interest due to their important role in promoting adaptive immunity against pathogens and cancer as well as regulating tolera
Publikováno v:
Semin Cell Dev Biol
Our understanding of the molecular events underpinning the development of mammalian organ systems has been increasing rapidly in recent years. With the advent of new and improved next-generation sequencing methods, we are now able to dig deeper than
Publikováno v:
Søe, K, Delaissé, J-M & Goldberg Borggaard, X 2021, ' Osteoclast formation at the bone marrow/bone surface interface: Importance of structural elements, matrix, and intercellular communication ', Seminars in Cell and Developmental Biology, vol. 112, pp. 8-15 . https://doi.org/10.1016/j.semcdb.2020.05.016
Osteoclasts, the multinucleated cells responsible for bone resorption, have an enormous destructive power which demands to be kept under tight control. Accordingly, the identification of molecular signals directing osteo- clastogenesis and switching