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Autor:
Kathleen F. Holton, Gabrielle L. Sarlo
Publikováno v:
Seizure. 91:213-227
An imbalance between excitation and inhibition has been a longstanding proposed mechanism regarding ictogenesis and epileptogenesis. This imbalance is related to increased extracellular glutamate in the brain and/or reduction in GABA concentrations,
Publikováno v:
Seizure. 91:159-166
Purpose To retrospectively investigate the prevalence, demography, antiseizure medication (ASM) usage, healthcare resource utilization (HCRU), and mortality of patients with Lennox-Gastaut syndrome (LGS) in primary and secondary care in the UK. Metho
Autor:
Kirsty Hudgell, Laura Mantoan Ritter, Simona Balestrini, Lina Nashef, Katri Silvennoinen, Sanjay M. Sisodiya, Meneka K. Sidhu
Publikováno v:
Seizure. 91:5-8
We describe real-world experience with cannabidiol (CBD) in adults with Dravet Syndrome (DS) via GW Pharma early access programme at two UK neurology centres. Adults with genetically-confirmed DS had CBD added to existing therapy, titrated up to 20 m
Publikováno v:
Seizure. 90:67-73
Purpose To evaluate the effects of cannabidiol alone or in combination with antiseizure drugs in the expression of recurrent generalized seizures in a rat model. Methods Group A: Male Wistar rats received 3-mercaptopropionic acid (MP) every 12 h for
Autor:
Junya Kaneko, Kyoko Unemoto, Kazutoshi Sugaya, Takashi Tagami, Minoru Kubota, Masayoshi Kondo, Masamune Kuno, Makihiko Nagano, Mio Hotta, Hisamitsu Takase
Publikováno v:
Seizure. 89:41-44
Purpose: We aimed to evaluate the blood concentration of levetiracetam (LEV), as a second-line drug, in patients with status epilepticus (SE) in an emergency clinical setting. Methods: We prospectively evaluated 20 consecutive patients with SE admitt
Publikováno v:
Seizure. 89:12-18
Purpose Cutaneous adverse drug reactions (cADRs) are a major cause of lamotrigine (LTG) discontinuation. Remarkable variation in their reported incidence suggests confounders and diverse terms and definitions. The aim of this study was to identify im
Autor:
Jia He, Jiahang Sun, Yanmei Zhu, Long Ma, Haiyan Gou, Yuting Hou, Yan Chen, Yulan Zhu, Yunong Li
Publikováno v:
Seizure. 88:138-142
Background To determine treatment effects on the incidence of post-stroke epilepsy (PSE) using different doses of statin, a prospective hospital-based cohort study was designed to explore whether a double-dose statin treatment can better prevent the
Autor:
Vera Bzhilyanskaya, Leenah Afridi, Alison Raffman, Asma Rashid, Jamie Palmer, Mehboob Rehan, Mahmood Ahmad, Ali Pourmand, Ashley Menne, Quincy K. Tran
Publikováno v:
Seizure. 87:46-55
Introduction Spontaneous intracerebral haemorrhage (ICH) is associated with high mortality and high morbidity, including seizures. Seizure prophylaxis is “not recommended” by the American Stroke Association, but practice variation still exists du
Autor:
Lesa Dawman, Pragnya Panda, Indar Kumar Sharawat, Ananthanarayanan Kasinathan, Kriti Joshi, Prateek Kumar Panda
Publikováno v:
Seizure. 85:119-126
Dravet syndrome (DS) is an infantile-onset developmental and epileptic encephalopathy syndrome with limited treatment options. We aimed to evaluate the efficacy and tolerability of fenfluramine in patients with Dravet syndrome using meta-analytical t
Publikováno v:
Seizure. 84:116-121
Purpose Viral encephalitis (VE) or bacterial meningoencephalitis (BME) in early childhood may cause brain injury and neurological sequelae, including epilepsy. Postencephalitic epilepsy (PEE) characterized by epileptic spasms (ES) is a rare but serio