Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kyung-Sang Yu"'
Autor:
Su-jin Rhee, Seung Han Shin, Jaeseong Oh, Young Hwa Jung, Chang Won Choi, Han-Suk Kim, Kyung-Sang Yu
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Sildenafil is widely used off-label in pediatric patients with pulmonary arterial hypertension (PAH). This study was conducted to characterize the pharmacokinetics (PK) of sildenafil in term and preterm neonates with PAH, by developing a pop
Externí odkaz:
https://doaj.org/article/8229bf95561f4c5abd697f714839cfda
Autor:
Yoonhyuk Jang, Seonghae Yoon, Tae-Joon Kim, SeungHwan Lee, Kyung-Sang Yu, In-Jin Jang, Kon Chu, Sang Kun Lee
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract This study aimed to develop a pharmacokinetic (PK) model of oxcarbazepine (OXC) and analyse the relationship between monohydroxylated derivative (MHD), an active metabolite of OXC, and the adverse events of OXC. We obtained 711 OXC samples f
Externí odkaz:
https://doaj.org/article/6c0150e2099e43f5a9056c9e990cf932
Autor:
Bora Kim, Ji Won Lee, Kyung Taek Hong, Kyung-Sang Yu, In-Jin Jang, Kyung Duk Park, Hee Young Shin, Hyo Seop Ahn, Joo-Youn Cho, Hyoung Jin Kang
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Owing to its narrow therapeutic range and high pharmacokinetic variability, optimal dosing for busulfan is important to minimise overexposure-related systemic toxicity and underexposure-related graft failure. Using global metabolomics, we in
Externí odkaz:
https://doaj.org/article/06cab8cab19242ea84e84676399eeb22
Autor:
Tae Joon Kim, Kyung Sang Yu, Sang Kun Lee, Seonghae Yoon, Kon Chu, Yoonhyuk Jang, Seung-Hwan Lee, In-Jin Jang
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
This study aimed to develop a pharmacokinetic (PK) model of oxcarbazepine (OXC) and analyse the relationship between monohydroxylated derivative (MHD), an active metabolite of OXC, and the adverse events of OXC. We obtained 711 OXC samples from 618 p
Autor:
Jae Yong Chung, Seonghae Yoon, In-Jin Jang, Yewon Choi, Kyung Sang Yu, Joo Youn Cho, Yun Kim, Seo Hyun Yoon
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Scientific Reports
A lack of information regarding whether genetic polymorphisms of SLCO1B1 and ABCG2 affect the pharmacokinetics (PKs)/pharmacodynamics (PDs) of rosuvastatin in elderly subjects prevents optimal individualized pharmacotherapy of rosuvastatin in clinica
Autor:
Yoon-Keun Kim, In-Jin Jang, Jae Yong Chung, Kyung Sang Yu, Seung-Hwan Lee, Seonghae Yoon, Jinho Yang, Sang Chun Ji, Joo Youn Cho, Da Jung Kim
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Ursodeoxycholic acid (UDCA) is a metabolic by-product of intestinal bacteria, showing hepatoprotective effects. However, its underlying molecular mechanisms remain unclear. The purpose of this study was to elucidate the action mechanisms underlying t
Autor:
In-Jin Jang, Kyung Sang Yu, Jinho Yang, Yoon-Keun Kim, Seung-Hwan Lee, Seonghae Yoon, Sang Chun Ji, Joo Youn Cho, Da Jung Kim, Jae Yong Chung
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-1 (2019)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Autor:
In-Jin Jang, Hyun Woo Shin, Jae Yong Chung, Jong Wan Park, Sung Kweon Cho, Joo Youn Cho, Kyung Sang Yu, K.H. Cho
Publikováno v:
Scientific Reports
SCIENTIFIC REPORTS(5)
SCIENTIFIC REPORTS(5)
Metformin is a first-line drug for treating type 2 diabetes. Although metformin is known to phosphorylate AMP-activated protein kinase (AMPK), it is unclear how the glucose-lowering effect of metformin is related to AMPK activation. The aim of this s