Zobrazeno 1 - 10
of 15
pro vyhledávání: '"James A. Brown"'
Autor:
Masaki Mandai, Mana Taki, Kaoru Abiko, Junzo Hamanishi, Ikuo Konishi, Noriomi Matsumura, Koji Yamanoi, James B. Brown, Yuko Hosoe, Tsukasa Baba, Ryusuke Murakami, Ken Yamaguchi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Scientific Reports
Scientific Reports
Background Based on our previous phase II clinical trial of anti-programmed death-1 (PD-1) antibody nivolumab for platinum-resistant ovarian cancer (n=19, UMIN000005714), we aimed to identify the therapeutic response biomarkers to nivolumab in ovaria
Autor:
Hirohiko Tani, Noriomi Matsumura, Asuka Okunomiya, Yukiyasu Sato, Shiro Takamatsu, Eiji Kondoh, Miki Sugimoto, Akihito Horie, Junzo Hamanishi, James B. Brown, Masaki Mandai
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports
Scientific Reports
The in vitro growth (IVG) of human follicles is a potential fertility option for women for whom cryopreserved ovarian tissues cannot be transplanted due to the risk of cancer cell reintroduction; however, there is currently no established method. Fur
Autor:
Susan S. Hubbard, Haruko Wainwright, Nicola Falco, Baptiste Dafflon, Craig Ulrich, James B. Brown, Jackson Cothren, Florian Soom, K. B. Schaettle, Malcolm Williamson, John E. Peterson, Richard G. Ham, J. McEntire
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Scientific reports, vol 11, iss 1
Scientific Reports
Scientific reports, vol 11, iss 1
Scientific Reports
Understanding the interactions among agricultural processes, soil, and plants is necessary for optimizing crop yield and productivity. This study focuses on developing effective monitoring and analysis methodologies that estimate key soil and plant p
Autor:
James B. Brown, Karl Kumbier, Michelle Newcomer, Ved N. Bhoot, Marilou P. Sison-Mangus, Yiwei Cheng, Raphael M. Kudela
Publikováno v:
Scientific Reports
Scientific reports, vol 11, iss 1
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific reports, vol 11, iss 1
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Increasing occurrence of harmful algal blooms across the land–water interface poses significant risks to coastal ecosystem structure and human health. Defining significant drivers and their interactive impacts on blooms allows for more effective an
Autor:
Nathan Boley, Gayatry Mohapatra, James B. Brown, Kunwar D Narayan, Fabien Dachet, Tibor Valyi-Nagy, Anna Serafini, Thomas R. Gingeras, Jeffrey A. Loeb, Susan E. Celniker
Publikováno v:
Scientific Reports
Scientific reports, vol 11, iss 1
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific reports, vol 11, iss 1
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
As a means to understand human neuropsychiatric disorders from human brain samples, we compared the transcription patterns and histological features of postmortem brain to fresh human neocortex isolated immediately following surgical removal. Compare
Autor:
Mark Webber, Emer Bourke, Olga Kalinina, James A. Brown, Andrew McGuire, Grace Callagy, Emma Holian, Aliaa Shalaby, Catherine Curran, Michael J. Kerin, Maire-Caitlin Casey
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
Breast cancer is stratified into four distinct clinical subtypes, using three key biomarkers (Her2/Neu gene status, Estrogen and Progesterone receptor status). However, each subtype is a heterogeneous group, displaying significant variation in surviv
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Growing evidence suggests that peripheral factors to the brain driving neuro-inflammation could affect Alzheimer’s Disease (AD) and Parkinson’s Disease (PD) severity. Herpes simplex virus type 1 (HSV1) infection has been associated with AD while
Autor:
Janet K. Jansson, Michael Hang, Susan E. Celniker, Yurong Huang, James B. Brown, Sasha A. Langley, Antoine M. Snijders, Kristofer E. Bouchard, Gary H. Karpen, Jian-Hua Mao
Publikováno v:
Mao, JH; Langley, SA; Huang, Y; Hang, M; Bouchard, KE; Celniker, SE; et al.(2015). Identification of genetic factors that modify motor performance and body weight using Collaborative Cross mice. Scientific Reports, 5. doi: 10.1038/srep16247. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/57c6r2cr
Scientific reports, vol 5, iss 1
Scientific Reports
Scientific reports, vol 5, iss 1
Scientific Reports
Evidence has emerged that suggests a link between motor deficits, obesity and many neurological disorders. However, the contributing genetic risk factors are poorly understood. Here we used the Collaborative Cross (CC), a large panel of newly inbred
Autor:
Imanol Peña, Gonzalo Colmenarejo, Albane Kessler, Irene Roquero, Ignacio Cotillo, Ana I. Bardera, David W. Gray, Vinod Kumar, Emilio Alvarez, Alexander Sherstnev, Julio Alonso-Padilla, Ana Rodriguez, Miguel Navarro, Juan Cantizani, Vanessa Barroso, Francisco de Dios-Anton, James R. Brown, M. Pilar Manzano, Jose M. Fiandor, Julio Martin, David H. Drewry
Publikováno v:
Scientific Reports
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
Using whole-cell phenotypic assays, the GlaxoSmithKline high-throughput screening (HTS) diversity set of 1.8 million compounds was screened against the three kinetoplastids most relevant to human disease, i.e. Leishmania donovani, Trypanosoma cruzi a
Autor:
Thomas Helleday, Melina Arcos Famme, Emer Bourke, Leif A. Eriksson, Chunxia Gao, James A. Brown, Martin Scobie, Noel F. Lowndes, Tobias Koolmeister
Publikováno v:
Scientific Reports
Histone acetylation is required for many aspects of gene regulation, genome maintenance and metabolism and dysfunctional acetylation is implicated in numerous diseases, including cancer. Acetylation is regulated by histone acetyltransferases (HATs) a