Zobrazeno 1 - 10
of 1 181
pro vyhledávání: '"11"'
Autor:
Francis G. Szele, Susana Frago, Nicholas B. Davies, Mirvat Surakhy, Martin Ducker, Claudia Bühnemann, Matthew P. Crump, Emma J. Carter, Sermet Can, Roman Trikin, A. Bassim Hassan, Jennifer Hughes
Publikováno v:
Scientific Reports
Hughes, J, Surakhy, M, Can, S, Ducker, M, Davies, N, Szele, F, Bühnemann, C, Carter, E, Trikin, R, Crump, M P, Frago, S & Hassan, A B 2019, ' Maternal transmission of an Igf2r domain 11 : IGF2 binding mutant allele (Igf2r I1565A ) results in partial lethality, overgrowth and intestinal adenoma progression ', Scientific Reports, vol. 9, no. 1, 11388 . https://doi.org/10.1038/s41598-019-47827-9
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Hughes, J, Surakhy, M, Can, S, Ducker, M, Davies, N, Szele, F, Bühnemann, C, Carter, E, Trikin, R, Crump, M P, Frago, S & Hassan, A B 2019, ' Maternal transmission of an Igf2r domain 11 : IGF2 binding mutant allele (Igf2r I1565A ) results in partial lethality, overgrowth and intestinal adenoma progression ', Scientific Reports, vol. 9, no. 1, 11388 . https://doi.org/10.1038/s41598-019-47827-9
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
The cation-independent mannose 6-phosphate/insulin-like growth factor-2 receptor (M6P/IGF2R or IGF2R) traffics IGF2 and M6P ligands between pre-lysosomal and extra-cellular compartments. Specific IGF2 and M6P high-affinity binding occurs via domain-1
Autor:
Alexander Gow, Farhad Ghoddoussi, Shane A. Perrine, Kathleen J. Maheras, Marcello Peppi, Matthew P. Galloway
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
Scientific Reports
Scientific Reports
Neuronal origins of behavioral disorders have been examined for decades to construct frameworks for understanding psychiatric diseases and developing useful therapeutic strategies with clinical application. Despite abundant anecdotal evidence for whi
Autor:
Jitske Jansen, Marinka Bakker-van Bebber, Fieke Mooren, Markus A. Loeven, Brigith Willemsen, Jennifer Eymael, Catherine Meyer-Schwesinger, Bart Smeets, Shagun Sharma, Jack F.M. Wetzels, Henry B.P.M. Dijkman, Johan van der Vlag, Laura Miesen
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports, 10
Scientific Reports
Scientific Reports, 10
Scientific Reports
Anti-Thy1.1 transgenic mice develop glomerular lesions that mimic collapsing focal segmental glomerulosclerosis (FSGS) in humans with collapse of the glomerular tuft and marked hyperplasia of the parietal epithelial cells (PECs). Immunostaining of ph
Autor:
David J. Prezant, Erin J. Caraher, Mengling Liu, Anna Nolan, Rachel Zeig-Owens, Sophia Kwon, Liqun Zhang, Rachel Lam, Audrey K. Lee, George Crowley, Theresa Schwartz, Syed Hissam Haider
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
Scientific Reports
Scientific Reports
Gastroesophageal reflux disease (GERD) and Barrett’s Esophagus (BE), which are prevalent in the World Trade Center (WTC) exposed and general populations, negatively impact quality of life and cost of healthcare. GERD, a risk factor of BE, is linked
Autor:
Jeroen H. F. de Baaij, Steef Kurstjens, Mohamed Kebieche, Hacene Bouras, Joost G. J. Hoenderop, Caro Overmars-Bos, René J. M. Bindels
Publikováno v:
Scientific Reports, 9
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Approximately 30% of patients with type 2 diabetes mellitus (T2D) have hypomagnesemia (blood magnesium (Mg2+) concentration 2+ levels. To investigate how T2D and metformin affect Mg2+ homeostasis db/m and db/db mice were treated with metformin or pla
Autor:
Hailong Jiang, Jie Wang, Wenjun Chang, Chuan-Xiang Zhou, An Li, Fuao Cao, Yan Huang, Yamin Pan, Lei Qiu, Jianzhong Li, Hao Shen, Yiming Lu
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Tyrosine phosphatase SHP2, encoded by PTPN11, has been implicated in many physiologic and pathologic processes in neoplastic progression. However, controversies are emerging from many studies, indicating SHP2 has a dual role in different types of tum
Autor:
Servio H. Ramirez, Divya Sagar, Ramila Philip, Allison M. Andrews, Xiaofang Huang, Prakash S. Nagarkatti, Jürgen Ruland, Narendra P. Singh, Mitzi Nagarkatti, Pooja Jain, Zafar K. Khan, Konstantin Neumann, Rashida Ginwala
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Scientific Reports
Scientific Reports
The mechanism of dendritic cells (DCs) recruitment across the blood brain barrier (BBB) during neuroinflammation has been the least explored amongst all leukocytes. For cells of myeloid origin, while integrins function at the level of adhesion, the i
Autor:
Guoyu Pan, Yimeng Gao, Xuan Ni, Le Wang, Zhitao Wu, Leilei Ma, Lijian Hui, Chen Chen, Yunfei Lin
Publikováno v:
Scientific Reports
Drug-induced cholestasis is a leading cause of drug withdrawal. However, the use of primary human hepatocytes (PHHs), the gold standard for predicting cholestasis in vitro, is limited by their high cost and batch-to-batch variability. Mature hepatocy
Autor:
Marc Pellegrini, Christina Nedeva, Ann Lin, Jason Glab, Lorraine A. O'Reilly, Irvin Jose, Marcel Doerflinger, Cody C. Allison, Hamsa Puthalakath, Richard S. Hotchkiss
Publikováno v:
Scientific Reports
Sepsis-induced lymphopenia is a major cause of morbidities in intensive care units and in populations with chronic conditions such as renal failure, diabetes, HIV and alcohol abuse. Currently, other than supportive care and antibiotics, there are no
Publikováno v:
Scientific Reports
Several epidemiological studies suggested an increased incidence rate of multiple myeloma (MM) among first responders and other individuals who exposed to World Trade Center (WTC) dust. In this report, we provided evidence showing that WTC dust is po