Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Preclinical research"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports
BackgroundMüller cell (MC) inflammation is an early pathogenic step in the vision-threatening disease diabetic retinopathy (DR). Recent evidence indicates that diabetes-induced free fatty acid (FFA) dysregulation can elicit the release of inflammato
Autor:
Adrian Bailey, Kevin D. Burns, Jose L. Viñas, Rosendo A. Rodriguez, Sarah Zankar, David S. Allan, Mayra Trentin-Sonoda
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
AKI has a high mortality rate, may lead to chronic kidney disease, and effective therapies are lacking. Micro-RNAs (miRNAs) regulate biologic processes by potently inhibiting protein expression, and pre-clinical studies have explored their roles in A
Autor:
Myung Hee Chung, Chul Park, Sang Taek Im, Mee Kum Kim, Dong Hyun Kim, Jin Young Yoon, Seunghoon Kim
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports
We compared the therapeutic effects of topical 8-oxo-2′-deoxyguanosine (8-oxo-dG) and corticosteroid in a murine ocular alkali burn model. (n = 128) The corneal alkali burn model was established by applying 0.1 N sodium hydroxide (NaOH), followed b
Autor:
Watcharamat Muangkaew, Kanchana Kengkoom, Passanesh Sukphopetch, Sumate Ampawong, Tapanee Kanjanapruthipong, Theerapong Buaban, Pornanong Aramwit
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
Psoriasis is mainly caused because of inappropriate immune responses in the epidermis. Rice (Oryza sativa L.: SRNC05053-6-2) consists of anthocyanin, which exhibits strong antioxidative and anti-inflammatory properties. This study aimed to evaluate t
Autor:
Chitraa Tangavel, Monica Steffi Matchado, K. S. Sri Vijay Anand, Niek Djuric, M. Raveendran, Dilip Chand Raja Soundararajan, Sharon Miracle Nayagam, Shanmuganathan Rajasekaran
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports, 10(1). NATURE RESEARCH
Scientific Reports
Scientific Reports, 10(1). NATURE RESEARCH
Intervertebral disc degeneration is accompanied by a loss of Extra-cellular matrix (ECM) due to an imbalance in anabolic and catabolic pathways. Identifying ECM proteins with anabolic and/or regenerative potential could be the key to developing regen
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
The most challenging issue for breast cancer (BC) patients is metastasis to other organs because current therapies do not prevent or eliminate metastatic BC. Here, we show that SM-164, a small molecule inhibitor, which degrades inhibitor of apoptosis
Autor:
Elena Chiricozzi, Margherita Maggioni, Maria Fazzari, Erika Di Biase, Pamela Fato, Gianluca Verlengia, Gusheng Wu, Diego Yuri Pomè, Simona Prioni, Giulia Lunghi, Laura Mauri, Stefano Cattaneo, Robert Assini, Sandro Sonnino, Robert W. Ledeen, Nicoletta Loberto, Samar K. Alselehdar, Manuela Valsecchi, Maria Grazia Ciampa
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports
Scientific Reports
Given the recent in vitro discovery that the free soluble oligosaccharide of GM1 is the bioactive portion of GM1 for neurotrophic functions, we investigated its therapeutic potential in the B4galnt1+/− mice, a model of sporadic Parkinson’s diseas
Autor:
Kaori Wakamatsu, Eita Sasaki, Keiko Furuhata, Takuo Mizukami, Hideki Kusunoki, Isao Hamaguchi, Haruka Momose, Kazuo Hosoda
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Scientific Reports
The safety evaluation of vaccines is critical to avoid the development of side effects in humans. To increase the sensitivity of detection for toxicity tests, it is important to capture not only pathological changes but also physiological changes. 1H
Autor:
Julia Starlinger, Mathias Kecht, Seyedhossein Aharinejad, Florian Koerbler, Kambiz Sarahrudi, Peter Pietschmann
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Macrophage colony-stimulating factor 1 (M-CSF) is known to play a critical role during fracture repair e.g. by recruiting stem cells to the fracture site and impacting hard callus formation by stimulating osteoclastogenesis. The aim of this experimen
Autor:
E. Ruiz-Del-Yerro, Aina Anton-Martinez, Javier Poyatos-Garcia, Edurne Albiasu-Arteta, Laura de la Puente-Ovejero, Gabriela Gonzalez-Iglesias, Patricia Soblechero-Martín, Virginia Arechavala-Gomeza, I. Garcia-Jimenez, Irene Larranaga-Aiestaran, Federico Gonzalez, Andrea López-Martínez
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
SCIENTIFIC REPORTS
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Scientific Reports
SCIENTIFIC REPORTS
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Gene editing methods are an attractive therapeutic option for Duchenne muscular dystrophy, and they have an immediate application in the generation of research models. To generate myoblast cultures that could be useful in in vitro drug screening, we